Results 61 to 70 of about 243,904 (249)

Umbilical cord-mesenchymal stem cells induce a memory phenotype in CD4+ T cells

Frontiers in Immunology, 2023
Inflammation is a physiological state where immune cells evoke a response against detrimental insults. Finding a safe and effective treatment for inflammation associated diseases has been a challenge.
Ezgi Sengun, Tim G. A. M. Wolfs, Valéry L. E. van Bruggen, Bram van Cranenbroek, Elles R. Simonetti, Daan Ophelders, Marien I. de Jonge, Irma Joosten, Renate G. van der Molen   +8 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Enriching central memory T cells using novel bioreactor design for T cell manufacturing

Cytotherapy
The manufacturing of T cell therapies aims to achieve high yields of product with potent phenotypes. We have developed a novel bioreactor, bioreactor with expandable culture area-dual chamber (BECA-D), which has previously demonstrated functionality for scaled T cell manufacturing.Methods and Results: In this study, incorporation of a stirring ...
Sixun Chen, Akshaya V. Prabhu, Ahmad Amirul Bin Abdul Rahim, Kang-Zheng Lee, Dan Liu   +4 more
openaire   +2 more sources

Naïve and central memory T-cell lymphopenia in end-stage renal disease [PDF]

Kidney International, 2006
End-stage renal disease (ESRD) is associated with increased propensity to infections, diminished response to vaccination, impaired cell-mediated immunity, and reduced CD4+/CD8+ T-lymphocyte ratio. Four subsets of CD4+ and CD8+ T cells have been recently identified: naïve cells (as yet uncommitted), central memory (CM) cells (previously programmed), and
Yoon, J.-W., Gollapudi, S., Pahl, M.V., Vaziri, N.D.   +3 more
openaire   +2 more sources

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Proliferation-linked apoptosis of adoptively transferred T cells after IL-15 administration in macaques. [PDF]

PLoS ONE, 2013
The adoptive transfer of antigen-specific effector T cells is being used to treat human infections and malignancy. T cell persistence is a prerequisite for therapeutic efficacy, but reliably establishing a high-level and durable T cell response by ...
Carolina Berger, Michael Berger, Brian C Beard, Hans-Peter Kiem, Theodore A Gooley, Stanley R Riddell   +5 more
doaj   +1 more source

Molecular Signatures Distinguish Human Central Memory from Effector Memory CD8 T Cell Subsets [PDF]

The Journal of Immunology, 2005
Abstract Memory T cells are heterogeneous in terms of their phenotype and functional properties. We investigated the molecular profiles of human CD8 naive central memory (TCM), effector memory (TEM), and effector memory RA (TEMRA) T cells using gene expression microarrays and phospho-protein-specific intracellular flow cytometry.
Willinger, Tim, Freeman, Tom, Hasegawa, Hitoshi, McMichael, Andrew J, Callan, Margaret F C   +4 more
openaire   +3 more sources

What can functional transcranial Doppler ultrasonography reveal about the cerebral lateralization of writing

FEBS Letters, EarlyView.
Which brain hemisphere controls writing? This review synthesizes all five functional transcranial Doppler studies of writing (handwriting and typing) published to date in adults and children. Right‐handers show left‐hemispheric dominance for the linguistic component of writing (written word generation), whereas findings for left‐handers remain ...
Marietta Papadatou‐Pastou
wiley   +1 more source

Inhibition of TGF-β1 Signaling Promotes Central Memory T Cell Differentiation [PDF]

The Journal of Immunology, 2013
Abstract This study affirmed that isolated CD8+ T cells express mRNA and produce TGF-β following cognate peptide recognition. Blockage of endogenous TGF-β with either a TGF-β–blocking Ab or a small molecule inhibitor of TGF-βRI enhances the generation of CD62Lhigh/CD44high central memory CD8+ T cells accompanied with a robust recall ...
Shinji, Takai, Jeffrey, Schlom, Joanne, Tucker, Kwong Y, Tsang, John W, Greiner   +4 more
openaire   +2 more sources

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source