Results 41 to 50 of about 243,904 (249)

EFFECTS OF γс-CYTOKINES (IL-2, IL-7 AND IL-15) UPON IN VITRO MATURATION AND DIFFERENTIATION OF CD4⁺CD45RО⁺/CD8⁺CD45RО⁺ T CELLS

Медицинская иммунология, 2018
Effect of γс-cytokines (IL-2, IL-7 и IL-15) upon maturation and differentiation of cytotoxic and helper CD45RО+ Tcell population was studied in the homeostatic in vitro culture conditions.
K. A. Yurova, O. G. Khaziakhmatova, N. M. Todosenko, L. S. Litvinova   +3 more
doaj   +1 more source

Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis

Journal of Translational Medicine, 2007
Background Alefacept (anti-CD2) biological therapy selectively targets effector memory T cells (Tem) in psoriasis vulgaris, a model Type 1 autoimmune disease.
Novitskaya Inna, Khatcherian Artemis, Cardinale Irma, Sullivan-Whalen Mary, Gilleaudeau Patricia, Kikuchi Toyoko, Lee Edmund, Lin Shao-Lee, Chamian Francesca, Wittkowski Knut M, Krueger James G, Lowes Michelle A   +11 more
doaj   +1 more source

Memory T cells: strategies for optimizing tumor immunotherapy

Protein & Cell, 2020
Several studies have demonstrated that memory T cells including stem cell memory (Tscm) T cells and central memory (Tcm) T cells show superior persistence and antitumor immunity compared with effector memory T (Tem) cells and effector T (Teff) cells ...
Qingjun Liu, Zhongjie Sun, Ligong Chen
doaj   +1 more source

CMV‐specific central memory T cells reside in bone marrow [PDF]

European Journal of Immunology, 2007
AbstractCMV‐specific CD8+ T cell responses in peripheral blood (PB) are characterized by a preponderance of effector and effector memory T cells. CMV‐specific central memory T cells (TCM), which are considered crucial in maintaining long‐term immunity, are rarely detectable in PB.
Anne, Letsch, Maren, Knoedler, Il-Kang, Na, Florian, Kern, Anne-Marie, Asemissen, Ulrich, Keilholz, Michael, Loesch, Eckhard, Thiel, Hans-Dieter, Volk, Carmen, Scheibenbogen   +9 more
openaire   +2 more sources

Quantifying Susceptibility of CD4+ Stem Memory T-Cells to Infection by Laboratory Adapted and Clinical HIV-1 Strains

Viruses, 2014
CD4+ T cells are principal targets for human immunodeficiency virus type 1 (HIV-1) infection. CD4+ T cell subsets are heterogeneous cell populations, divided by functional and phenotypic differences into naïve and memory T cells.
Jacqueline K. Flynn, Geza Paukovics, Kieran Cashin, Katharina Borm, Anne Ellett, Michael Roche, Martin R. Jakobsen, Melissa J. Churchill, Paul R. Gorry   +8 more
doaj   +1 more source

Non-hematopoietic cells in lymph nodes drive memory CD8 T cell inflation during murine cytomegalovirus infection. [PDF]

PLoS Pathogens, 2011
During human and murine cytomegalovirus (MCMV) infection an exceptionally large virus-specific CD8 T cell pool is maintained in the periphery lifelong.
Nicole Torti, Senta M Walton, Thomas Brocker, Thomas Rülicke, Annette Oxenius   +4 more
doaj   +1 more source

SARS-CoV-2 reactive memory T cell immunity in healthy individuals

Zhongguo shuxue zazhi, 2022
Objective To understand the memory phenotype and function of SARS-CoV-2 reactive CD4+ T cells in healthy individuals. Methods In this study, SARS-CoV-2-derived peptides were used to stimulate PBMC from participants.SARS-CoV-2 reactive memory T cells were
Chen LUO, Yonghua YIN, Yudi XIE, Zhihang HE, Ling LI, Zhong LIU, Jue WANG, Qiang CHEN   +7 more
doaj   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Reorganization and functional divergence of the CD4+ memory T cell compartment in hidradenitis suppurativa

Frontiers in Immunology
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with poorly understood and complex pathophysiology with interplay between many immune and stromal cells.
Laura Casals-Diaz, Jorge Romaní, Abir Ezzaanouni, Abir Ezzaanouni, Madalina Raducu, Cristina Vila, Lluís Boix, Amadeu Gavaldà, Antonio Guilabert, Antonio Guilabert   +9 more
doaj   +1 more source

Secondary memory CD8+ T cells are more protective but slower to acquire a central–memory phenotype [PDF]

The Journal of Experimental Medicine, 2006
The formation of memory CD8 T cells is an important goal of vaccination. However, although widespread use of booster immunizations in humans generates secondary and tertiary CD8 T cell memory, experimental data are limited to primary CD8 T cell memory.
Jabbari, Ali, Harty, John T.
openaire   +2 more sources