Results 21 to 30 of about 243,904 (249)

Cutting Edge: Central Memory CD8 T Cells in Aged Mice Are Virtual Memory Cells [PDF]

The Journal of Immunology, 2013
Abstract The number of memory phenotype CD8 T cells increases dramatically with aging in both humans and mice. However, the mechanism for this is unknown. The prevailing hypothesis is that memory T cells accumulate with aging as a result of lifelong antigenic stimulation. However, data supporting this supposition are lacking.
Bo-Chin, Chiu, Brian E, Martin, Valerie R, Stolberg, Stephen W, Chensue   +3 more
openaire   +2 more sources

Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance [PDF]

Annual Review of Immunology, 2004
The memory T cell pool functions as a dynamic repository of antigen-experienced T lymphocytes that accumulate over the lifetime of the individual. Recent studies indicate that memory T lymphocytes contain distinct populations of central memory (T CM ) and effector memory (T
Federica, Sallusto, Jens, Geginat, Antonio, Lanzavecchia   +2 more
openaire   +4 more sources

Manufacture of Gene-Modified Human T-Cells with a Memory Stem/Central Memory Phenotype [PDF]

Human Gene Therapy Methods, 2014
Advances in genetic engineering have made it possible to generate human T-cell products that carry desired functionalities, such as the ability to recognize cancer cells. The currently used strategies for the generation of gene-modified T-cell products lead to highly differentiated cells within the infusion product, and on the basis of data obtained in
Gomez-Eerland, Raquel, Nuijen, Bastiaan, Heemskerk, Bianca, van Rooij, Nienke, van den Berg, Joost H, Beijnen, Jos H, Uckert, Wolfgang, Kvistborg, Pia, Schumacher, Ton N, Haanen, John B A G, Jorritsma, Annelies   +10 more
openaire   +4 more sources

BCG vaccination induces enhanced frequencies of memory T cells and altered plasma levels of common γc cytokines in elderly individuals

PLoS ONE, 2021
BCG vaccination is known to induce innate immune memory, which confers protection against heterologous infections. However, the effect of BCG vaccination on the conventional adaptive immune cells subsets is not well characterized.
Nathella Pavan Kumar, Chandrasekaran Padmapriyadarsini, Anuradha Rajamanickam, Perumal Kannabiran Bhavani, Arul Nancy, Bharathi Jayadeepa, Nandhini Selvaraj, Dinesh Asokan, Rachel Mariam Renji, Vijayalakshmi Venkataramani, Srikanth Tripathy, Subash Babu   +11 more
doaj   +2 more sources

Age related human T cell subset evolution and senescence

Immunity & Ageing, 2019
T cells are fundamental effector cells against viruses and cancers that can be divided into different subsets based on their long-term immune protection and immediate immune response effects.
Mingde Li, Danlin Yao, Xiangbo Zeng, Dimitri Kasakovski, Yikai Zhang, Shaohua Chen, Xianfeng Zha, Yangqiu Li, Ling Xu   +8 more
doaj   +1 more source

Central memory CD4+ T cells dominate the normal cerebrospinal fluid [PDF]

Cytometry Part B: Clinical Cytometry, 2010
To use cerebrospinal fluid (CSF) immune phenotyping as a diagnostic and research tool, we have set out to establish reference values of white blood cell (WBC) subsets in CSF.We assessed the absolute numbers and percentages of WBC subsets by 6-color flow cytometry in paired CSF and blood samples of 84 individuals without neurological disease who ...
Graaf, Marieke, Sillevis Smitt, Peter, Luitwieler, RL, van Velzen, C, Broek, Patricia, Kraan, Juliette, Gratama, Jan willem   +6 more
openaire   +3 more sources

Selected microRNAs define cell fate determination of murine central memory CD8 T cells.

PLoS ONE, 2010
During an immune response T cells enter memory fate determination, a program that divides them into two main populations: effector memory and central memory T cells. Since in many systems protection appears to be preferentially mediated by T cells of the
Gonzalo Almanza, Antonio Fernandez, Stefano Volinia, Xochitl Cortez-Gonzalez, Carlo M Croce, Maurizio Zanetti   +5 more
doaj   +1 more source

Immunotherapeutic Potential of T Memory Stem Cells

Frontiers in Oncology, 2021
Memory T cells include T memory stem cells (TSCM) and central memory T cells (TCM). Compared with effector memory T cells (TEM) and effector T cells (TEFF), they have better durability and anti-tumor immunity. Recent studies have shown that although TSCM
Yujie Li, Dengqiang Wu, Xuejia Yang, Sufang Zhou, Sufang Zhou   +4 more
doaj   +1 more source

Identification of immune cell infiltration and effective biomarkers of polycystic ovary syndrome by bioinformatics analysis

BMC Pregnancy and Childbirth, 2023
Background Patients with polycystic ovary syndrome (PCOS) exhibit a chronic inflammatory state, which is often accompanied by immune, endocrine, and metabolic disorders.
Mengge Gao, Xiaohua Liu, Mengxuan Du, Heng Gu, Hang Xu, Xingming Zhong   +5 more
doaj   +1 more source

Memory T cells skew toward terminal differentiation in the CD8+ T cell population in patients with acute myeloid leukemia

Journal of Hematology & Oncology, 2018
Stem cell memory T (TSCM) and central memory T (TCM) cells can rapidly differentiate into effector memory (TEM) and terminal effector (TEF) T cells, and have the most potential for immunotherapy. In this study, we found that the frequency of TSCM and TCM
Ling Xu, Danlin Yao, Jiaxiong Tan, Zifan He, Zhi Yu, Jie Chen, Gengxin Luo, Chunli Wang, Fenfang Zhou, Xianfeng Zha, Shaohua Chen, Yangqiu Li   +11 more
doaj   +1 more source