Results 31 to 40 of about 243,904 (249)

Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates [PDF]

Journal of Clinical Investigation, 2008
The adoptive transfer of antigen-specific T cells that have been expanded ex vivo is being actively pursued to treat infections and malignancy in humans. The T cell populations that are available for adoptive immunotherapy include both effector memory and central memory cells, and these differ in phenotype, function, and homing.
Carolina, Berger, Michael C, Jensen, Peter M, Lansdorp, Mike, Gough, Carole, Elliott, Stanley R, Riddell   +5 more
openaire   +2 more sources

High CCR5 density on central memory CD4+ T cells in acute HIV-1 infection is mostly associated with rapid disease progression. [PDF]

PLoS ONE, 2012
CD4+ central memory T cells play a critical role in the pathogenesis of simian immunodeficiency virus disease, and the CCR5 density on the surface of CD4 T cells is an important factor in human immunodeficiency virus (HIV)-1 disease progression.
Xue Yang, Yan-mei Jiao, Rui Wang, Yun-xia Ji, Hong-wei Zhang, Yong-hong Zhang, De-xi Chen, Tong Zhang, Hao Wu   +8 more
doaj   +1 more source

Hoxb4 overexpression in CD4 memory phenotype T cells increases the central memory population upon homeostatic proliferation. [PDF]

PLoS ONE, 2013
Memory T cell populations allow a rapid immune response to pathogens that have been previously encountered and thus form the basis of success in vaccinations.
Héloïse Frison, Gloria Giono, Paméla Thébault, Marilaine Fournier, Nathalie Labrecque, Janet J Bijl   +5 more
doaj   +1 more source

T Lymphocyte Maturation Profile in the EBUS-TBNA Lymph Node Depending on the DLCO Parameter in Patients with Pulmonary Sarcoidosis

Cells, 2021
Sarcoidosis (SA) is a systemic granulomatous disorder of unknown etiology with lung and mediastinal lymph nodes (LNs) as the main location. T lymphocytes play important role in the formation of granulomas in SA, but still little is known about the role ...
Elżbieta Rutkowska, Iwona Kwiecień, Joanna Bednarek, Rafał Sokołowski, Agata Raniszewska, Karina Jahnz- Różyk, Piotr Rzepecki   +6 more
doaj   +1 more source

Bystander Central Memory but Not Effector Memory CD8+ T Cells Suppress Allograft Rejection [PDF]

The Journal of Immunology, 2008
Abstract Memory T cells respond faster and more vigorously than their naive counterparts and are critical for adaptive immunity. However, it is unknown whether and how memory T cells react in the face of irrelevant Ags. It is generally accepted that bystander memory T cells are neutral in immune responsiveness.
Ni, Wan, Hehua, Dai, Tao, Wang, Yolonda, Moore, Xin Xiao, Zheng, Zhenhua, Dai   +5 more
openaire   +2 more sources

Comparison of the Development of SARS-Coronavirus-2-Specific Cellular Immunity, and Central Memory CD4+ T-Cell Responses Following Infection versus Vaccination

Vaccines, 2021
Memory T-cell responses following infection with coronaviruses are reportedly long-lived and provide long-term protection against severe disease. Whether vaccination induces similar long-lived responses is not yet clear since, to date, there are limited ...
Kevin M. Dennehy, Eva Löll, Christine Dhillon, Johanna-Maria Classen, Tobias D. Warm, Lukas Schuierer, Alexander Hyhlik-Dürr, Christoph Römmele, Yvonne Gosslau, Elisabeth Kling, Reinhard Hoffmann   +10 more
doaj   +1 more source

A Pool of Central Memory-Like CD4 T Cells Contains Effector Memory Precursors [PDF]

The Journal of Immunology, 2003
Abstract The L51S mutation in the D10.G4.1 TCR α-chain reduces the affinity of the TCR to its ligand by affecting the interactions among the TCR, the β-chain of I-Ak, and the bound peptide. We show that this mutation drives the generation of a pool of memory CD44highCD62LnegCD45RBneg CD4 TCR transgenic T cells.
J Magarian, Blander, Derek B, Sant'Angelo, Daniela, Metz, Sang-Won, Kim, Richard A, Flavell, Kim, Bottomly, Charles A, Janeway   +6 more
openaire   +2 more sources

Recombinant BCG expressing the LTAK63 adjuvant increased memory T cells and induced long-lasting protection against Mycobacterium tuberculosis challenge in mice

Frontiers in Immunology, 2023
Vaccine-induced protection against Mycobacterium tuberculosis (Mtb) is usually ascribed to the induction of Th1, Th17, and CD8+ T cells. However, protective immune responses should also involve other immune cell subsets, such as memory T cells.
Lázaro Moreira Marques-Neto, Monalisa Martins Trentini, Alex Issamu Kanno, Dunia Rodriguez, Luciana Cezar de Cerqueira Leite   +4 more
doaj   +1 more source

Role of Immunological Memory Cells as a Therapeutic Target in Multiple Sclerosis

Brain Sciences, 2017
Pharmacological targeting of memory cells is an attractive treatment strategy in various autoimmune diseases, such as psoriasis and rheumatoid arthritis.
Tanima Bose
doaj   +1 more source

Unidirectional development of CD8⁺ central memory T cells into protective Listeria‐specific effector memory T cells [PDF]

European Journal of Immunology, 2006
AbstractThree distinct subsets of antigen‐experienced CD8+ T cells have been identified so far: short‐living effector T cells (TEC) and two long‐living subsets, described as central (TCM) and effector memory (TEM) T cells. The lineage relationships of these subpopulations as well as their involvement in protection have not yet been conclusively ...
Katharina M, Huster, Martina, Koffler, Christian, Stemberger, Matthias, Schiemann, Hermann, Wagner, Dirk H, Busch   +5 more
openaire   +2 more sources