Results 11 to 20 of about 243,904 (249)

Origins of CD4(+) effector and central memory T cells. [PDF]

Nat Immunol, 2011
Lineage-committed effector CD4(+) T cells are generated at the peak of the primary response and are followed by heterogeneous populations of central and effector memory cells. Here we review the evidence that T helper type 1 (T(H)1) effector cells survive the contraction phase of the primary response and become effector memory cells.
Pepper M, Jenkins MK.
europepmc   +5 more sources

Rapid Transduction and Expansion of Transduced T Cells with Maintenance of Central Memory Populations [PDF]

Molecular Therapy: Methods & Clinical Development, 2020
Chimeric antigen receptor (CAR)-T cells show great promise in treating cancers and viral infections. However, most protocols developed to expand T cells require relatively long periods of time in culture, potentially leading to progression toward ...
Mary S. Pampusch, Kumudhini Preethi Haran, Geoffrey T. Hart, Eva G. Rakasz, Aaron K. Rendahl, Edward A. Berger, Elizabeth Connick, Pamela J. Skinner   +7 more
doaj   +3 more sources

Differential Contributions of Central and Effector Memory T Cells to Recall Responses [PDF]

Journal of Experimental Medicine, 2005
Although the absolute number of memory CD8+ T cells established in the spleen following antigen encounter remains stable for many years, the relative capacity of these cells to mediate recall responses is not known. Here we used a dual adoptive transfer approach to demonstrate a progressive increase in the quality of memory T cell pools in terms of ...
Alan D Roberts, Kenneth H Ely, David L Woodland   +2 more
exaly   +3 more sources

Cytokine-Driven Proliferation and Differentiation of Human Naive, Central Memory, and Effector Memory CD4+ T Cells [PDF]

Journal of Experimental Medicine, 2001
Memory T lymphocytes proliferate in vivo in the absence of antigen maintaining a pool of central memory T cells (TCM) and effector memory T cells (TEM) with distinct effector function and homing capacity. We compared human CD4+ naive T, TCM, and TEM cells for their capacity to proliferate in response to cytokines, that have been implicated in T cell ...
Antonio Lanzavecchia, Federica Sallusto, Jens Geginat   +2 more
exaly   +6 more sources

Central memory T cells are the most effective precursors of resident memory T cells in human skin. [PDF]

Sci Immunol, 2022
The circulating precursor cells that give rise to human resident memory T cells (T RM ) are poorly characterized. We used an in vitro differentiation system and human skin–grafted mice to study T RM generation from circulating human memory T cell subsets. In vitro T RM
Matos TR, Gehad A, Teague JE, Dyring-Andersen B, Benezeder T, Dowlatshahi M, Crouch J, Watanabe Y, O'Malley JT, Kupper TS, Yang C, Watanabe R, Clark RA.   +12 more
europepmc   +4 more sources

CD8+CD122+ T-cells: a newly emerging regulator with central memory cell phenotypes [PDF]

Frontiers in Immunology, 2015
CD8+CD122+ T-cells have been traditionally described as antigen-specific memory T-cells that respond to previously encountered antigens more quickly and vigorously than their naïve counterparts.
Dacan eChen, Dacan eChen, Junfeng eLiu, Junfeng eLiu, Golay eNie, Zhenhua eDai, Zhenhua eDai   +6 more
doaj   +3 more sources

Smad4 represses the generation of memory-precursor effector T cells but is required for the differentiation of central memory T cells. [PDF]

Cell Death Dis, 2015
Abstract The transcriptional regulation underlying the differentiation of CD8 + effector and memory T cells remains elusive. Here, we show that 18-month-old mice lacking the transcription factor Smad4 (homolog 4 of mothers against decapentaplegic ...
Cao J, Zhang X, Wang Q, Qiu G, Hou C, Wang J, Cheng Q, Lan Y, Han H, Shen H, Zhang Y, Yang X, Shen B, Zhang J.   +13 more
europepmc   +4 more sources

Central memory T cells with key TCR repertoires and gene expression profiles dominate influenza CD8+ T cell pools across the human lifespan. [PDF]

Proc Natl Acad Sci U S A
Menon T, McQuilten HA, Samir J, Nguyen THO, Lim R, Kaur J, Rizzetto S, Eltahla A, Thomas PG, Lappas M, Rossjohn J, Gras S, Crowe J, Flanagan KL, Luciani F, Doherty PC, van de Sandt CE, Kedzierska K.   +17 more
europepmc   +2 more sources

A CD45RO+ stem cell memory T cell population intermediate to canonical stem cell memory and central memory T cells in human cancer. [PDF]

, 2022
Abstract T memory stem cells (Tscm) are integral for effective immunotherapy and antitumor responses, but little is known about Tscm immunobiology in solid human tumors. Here we identify self-renewing and multipotent Tscm tumor-infiltrating lymphocytes (TILs) in human cancer and present a novel Tscm subset which expresses CD45RO, is derived ...
Daniel Powell, Monika Eiva, Erica Brown, Veethika Pandey, Alexander Benton, Stacy Thomas, Wenzhao Meng, Aaron Rosenfeld, Eline Luning Prak   +8 more
openaire   +1 more source

Extensive Replicative Capacity of Human Central Memory T Cells [PDF]

The Journal of Immunology, 2004
Abstract To characterize the replicative capacity of human central memory (TCM) CD4 T cells, we have developed a defined culture system optimized for the ex vivo expansion of Ag-specific CD4+ T cells. Artificial APCs (aAPCs) consisting of magnetic beads coated with Abs to HLA class II and a costimulatory Ab to CD28 were prepared ...
Marcela V, Maus, Birgit, Kovacs, William W, Kwok, Gerald T, Nepom, Katia, Schlienger, James L, Riley, David, Allman, Terri H, Finkel, Carl H, June   +8 more
openaire   +2 more sources