Results 71 to 80 of about 1,988,517 (312)

Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations

FEBS Open Bio, EarlyView.
Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro, Afshan F. Nawas, Jessica A. Kilgore, Pedro A. S. Nogueira, M.Carmen Lafita‐Navarro, Paul H. Acosta, Roy Garcia, Noelle S. Williams, Maralice Conacci‐Sorrell   +8 more
wiley   +1 more source

Psychotherapeutic, pharmacological and other active interventions from the NICE guideline for post-traumatic stress disorder with sleep disorder: systematic review and meta-analysis

BMC Psychiatry
Background Post-traumatic stress disorder (PTSD) is strongly associated with sleep disorders, and current clinical guidelines for PTSD differ in recommending treatment for patients with PTSD associated with sleep disorders.
Yi-Fan Zhao, Cheng-Yang Huang, Zhi-Xin Zhang, Run-Ben Liu, Jia-Ling Liu, Xiao-Zheng Li, Guang-Ling Guo, Chao Zhang   +7 more
doaj   +1 more source

Metastatic involvement of the central nervous system in gynecological cancer

Опухоли женской репродуктивной системы, 2014
Metastatic involvement of the central nervous system (CNS) is very rarely observed in gynecological cancer . Ten case histories were analyzed in patients with malignancies of the cervix uteri, endometrium, and ovaries concurrent with metastatic ...
Yu. S. Sidorenko, S. V. Grigorov, V. E. Plotnikova   +2 more
doaj   +1 more source

The Brain-Gut-Microbiome Axis. [PDF]

, 2018
Preclinical and clinical studies have shown bidirectional interactions within the brain-gut-microbiome axis. Gut microbes communicate to the central nervous system through at least 3 parallel and interacting channels involving nervous, endocrine, and ...
Kalani, Amir, Martin, Clair R, Mayer, Emeran A, Osadchiy, Vadim   +3 more
core   +2 more sources

Cloning, expression, purification, and structural modeling of the Chandipura virus matrix protein

FEBS Open Bio, EarlyView.
This research protocol offers a guide for the cloning, expression, and purification of the Chandipura virus matrix protein using E. coli. It also includes a step‐by‐step procedure for cloning, expressing, and conducting fluorescence imaging of GFP‐fused Chandipura virus matrix protein in mammalian cell lines.
Mariana Grieben
wiley   +1 more source

Mitophagy-associated programmed neuronal death and neuroinflammation

Frontiers in Immunology
Mitochondria are crucial organelles that play a central role in cellular metabolism and programmed cell death in eukaryotic cells. Mitochondrial autophagy (mitophagy) is a selective process where damaged mitochondria are encapsulated and degraded through
Yanlin Zhu, Yanlin Zhu, Yanlin Zhu, Jianning Zhang, Jianning Zhang, Jianning Zhang, Quanjun Deng, Quanjun Deng, Quanjun Deng, Xin Chen, Xin Chen, Xin Chen   +11 more
doaj   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Inhibition of S100A8/A9 ameliorates neuroinflammation by blocking NET formation following traumatic brain injury

Redox Biology
Traumatic brain injury (TBI) triggers a robust inflammatory response that is closely linked to worsened clinical outcomes. S100A8/A9, also known as calprotectin or myeloid-related protein-8/14 (MRP8/14), is an alarmin primarily secreted by activated ...
Guihong Shi, Yiyao Cao, Jianye Xu, Bo Chen, Xu Zhang, Yanlin Zhu, Liang Liu, Xilei Liu, Luyuan Zhang, Yuan Zhou, Shenghui Li, Guili Yang, Xiao Liu, Fanglian Chen, Xin Chen, Jianning Zhang, Shu Zhang   +16 more
doaj   +1 more source

Modelling the spatial organization of cell proliferation in the developing central nervous system [PDF]

, 2010
How far is neuroepithelial cell proliferation in the developing central nervous system a deterministic process? Or, to put it in a more precise way, how accurately can it be described by a deterministic mathematical model?
Clairambault, Jean, Flores, Vladimir, Perthame, Benoit, Rapacioli, Melina, Rofman, Edmundo, Verdes, Rafael   +5 more
core   +3 more sources

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source