Results 81 to 90 of about 24,552,875 (310)

An ioversol-enhanced micro-CT workflow for hematoma visualization and preoperative localization in a murine autologous blood model of intracerebral hemorrhage

Scientific Reports
Autologous blood injection produces a discrete striatal clot in mice, but the hematoma is usually confirmed only after brain removal and sectioning, making craniotomy planning difficult for evacuation studies. To address this limitation, we mixed freshly
Hao Peng, Rui Zhou, Wenhao Chen, Xingchun Gao, Junti Lu, Yin Xiong, Zhizhen Wei, Anwei Zhang, Kuanming Huang, Xiangjun Tang, Rui Fu   +10 more
doaj   +1 more source

Central Nervous System Tuberculosis

Microbiology Spectrum, 2017
ABSTRACTCentral nervous system tuberculosis (CNS-TB) takes three clinical forms: meningitis (TBM), intracranial tuberculoma, and spinal arachnoiditis. TBM predominates in the western world and presents as a subacute to chronic meningitis syndrome with a prodrome of malaise, fever, and headache progressing to altered mentation and focal neurologic signs,
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Electroacupuncture improves upper-limb motor function and modulates sensorimotor network connectivity in subacute stroke: a randomized controlled trial

Frontiers in Neurology
ObjectiveElectroacupuncture (EA) has been shown to facilitate post-stroke motor recovery; however, the underlying neurophysiological mechanisms remain insufficiently understood.
Mingfen Li, Weigeng Zou, Genggeng Xie, Man Li, Su Zheng, Haifeng Li   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic modification after inhibition of IGF-1R signaling in human central nervous system atypical teratoid rhabdoid tumor (AT/RT)

, 2013
OBJECTIVE: This study investigated epigenetic modifications in human central nervous system atypical teratoid rhabdoid tumors (AT/RTs), in response to inhibition of insulin-like growth factor receptor 1 (IGF-1R).
김동석, 심규원
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Effects of bromadiolone poisoning on the central nervous system

, 2017
Meiling Wang,1 Yanfeng Yang,2 Yiwei Hou,1 Wenbin Ma,1 Rui Jia,1 Jinbo Chen1 1Neurology Department, Binzhou Medical University Hospital, Binzhou Medical University, 2Binzhou Blood Center, Binzhou, China Abstract: Cases of rodenticide poisoning ...
Wang M, Yang Y, Chen J, Jia R, Hou Y, Ma W   +5 more
core