Results 71 to 80 of about 24,552,875 (310)

Serial serum calcium dynamics predict delayed hydrocephalus after spontaneous subarachnoid hemorrhage: development and validation of a clinical nomogram in an observational cohort

Frontiers in Neurology
BackgroundDelayed hydrocephalus, a severe complication following spontaneous subarachnoid hemorrhage (SAH), lacks reliable early biomarkers. Calcium dysregulation has emerged as a potential mediator of secondary brain injury, but the predictive value of ...
Di Wu, Di Wu, Di Wu, Xingye Zhai, Xingye Zhai, Xinyue Zhang, Xinyue Zhang, Xu Han, Lingyu Hao, Cong Wang, Cong Wang, Sihan Wang, Sihan Wang, Zhen Wang, Zhen Wang, Zengguang Wang, Zengguang Wang, Yi Wang, Yi Wang   +18 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The blood-central nervous system barriers actively control immune cell entry into the central nervous system

, 2008
Before entering the central nervous system (CNS) immune cells have to penetrate any one of its barriers, namely either the endothelial blood-brain barrier, the epithelial blood-cerebrospinal fluid barrier or the tanycytic barrier around the ...
Engelhardt, Britta, Engelhardt B
core   +1 more source

Inhibition of S100A8/A9 ameliorates neuroinflammation by blocking NET formation following traumatic brain injury

Redox Biology
Traumatic brain injury (TBI) triggers a robust inflammatory response that is closely linked to worsened clinical outcomes. S100A8/A9, also known as calprotectin or myeloid-related protein-8/14 (MRP8/14), is an alarmin primarily secreted by activated ...
Guihong Shi, Yiyao Cao, Jianye Xu, Bo Chen, Xu Zhang, Yanlin Zhu, Liang Liu, Xilei Liu, Luyuan Zhang, Yuan Zhou, Shenghui Li, Guili Yang, Xiao Liu, Fanglian Chen, Xin Chen, Jianning Zhang, Shu Zhang   +16 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Experimental Models of SARS-COV-2 Infection in the Central Nervous System

, 2022
Coronavirus disease 2019 (COVID-19) has raised serious concerns worldwide due to its great impact on human health and forced scientists racing to find effective therapies to control the infection and a vaccine for the virus. To this end, intense research
Anna Maria Paoletti, Immacolata Vecchio, Maria Grazia Melilli, Vecchio, Immacolata, Melilli MG, Melilli, Maria Grazia, Paoletti AM, Paoletti, Anna Maria, Vecchio I   +8 more
core   +1 more source

Metallothionein expression and roles in the central nervous system

, 2002
Central nervous system, inflammation, degeneration, regeneration ...
Penkowa, Milena
core   +1 more source

Mitophagy-associated programmed neuronal death and neuroinflammation

Frontiers in Immunology
Mitochondria are crucial organelles that play a central role in cellular metabolism and programmed cell death in eukaryotic cells. Mitochondrial autophagy (mitophagy) is a selective process where damaged mitochondria are encapsulated and degraded through
Yanlin Zhu, Yanlin Zhu, Yanlin Zhu, Jianning Zhang, Jianning Zhang, Jianning Zhang, Quanjun Deng, Quanjun Deng, Quanjun Deng, Xin Chen, Xin Chen, Xin Chen   +11 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Central Nervous System Infections

, 2016
This chapter provides an overview of infectious syndromes, pathogens, and diagnostic testing modalities for central nervous system infections in the immunocompromised host.
Andrea J. Zimmer, Victoria E. Burke, Karen C. Bloch   +2 more
core   +1 more source