Results 51 to 60 of about 23,298,365 (315)

HMGB1 affects the progression of neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors through E2F2

Cancer Cell International
Background Malignant peripheral nerve sheath tumors (MPNSTs) represent the most severe complication of neurofibromatosis type 1 (NF1), with limited therapeutic options and poor prognosis.
Shengqiao Sun, Chenhao Hu, Lebao Yu, Dezhi Li, Chao Guo, Song Liu   +5 more
doaj   +1 more source

Global Efforts to Reduce Paediatric Cancer Care Disparities in Radiotherapy: A Decade Change

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We present an update on the status, needs and challenges faced by paediatric imaging and radiotherapy (RT) programmes globally after a previous survey conducted by the International Atomic Energy Agency (IAEA) 10 years prior. Methods We developed and distributed a 121‐question survey to radiation oncologists, medical physicists and ...
Raymond B. Mailhot Vega, Daniel J. Indelicato, Jeanette Parkes, Natia Esiashvili, Josué Hernández Benítez, Miriam Mikhail‐Lette, Olivera Cirajc Bjelac, Daniel Berger, Eva Ciurana, Yavuz Anacak, Lisbeth Cordero‐Mendez   +10 more
wiley   +1 more source

Atorvastatin combined with dexamethasone in chronic subdural haematoma (ATOCH II): study protocol for a randomized controlled trial

Trials, 2021
Background Chronic subdural haematoma (CSDH) is a common condition in the elderly that often requires neurosurgical management. For small CSDH, evidence has emerged that statins may reduce haematoma volume and improve outcomes, presumably by reducing ...
Rong Cai Jiang, Dong Wang, Shi Guang Zhao, Ren Zhi Wang, De Zhi Kang, Xin Gen Zhu, Zong Mao Zhao, Jun Ji Wei, Ying Huang, Yan Qu, Xiao Chuan Sun, Hong Ming Ji, Xiao Chun Jiang, Jin Fang Liu, Xi De Zhu, Jian Jun Wang, Ye Tian, Chuang Gao, Hui Jie Wei, Shu Zhang, Wei Quan, Shu Yuan Yue, Ping Lei, Xian Li, Li Li Song, Craig S. Anderson, Jian Ning Zhang   +26 more
doaj   +1 more source

Neuropsychological and Educational Outcomes in Shwachman–Diamond Syndrome—A Report From the North American Shwachman–Diamond Syndrome Registry

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Shwachman–Diamond syndrome (SDS) is a rare autosomal recessive ribosomopathy characterized by bone marrow failure and multisystem involvement, with emerging evidence of associated neurocognitive impairment. Methods We conducted a retrospective study of 240 individuals with biallelic Shwachman–Bodian–Diamond syndrome (SBDS) mutations
Jane Koo, Melissa Gerstle, Leah Cheng, Richard Cooper, Katherine Coyne, Claire Dusa, Naomi E. Joffe, Diana Schwarz, Sarah Steltz, Akiko Shimamura, Kasiani C. Myers, Thea Quinton   +11 more
wiley   +1 more source

A Situational Assessment of the Diagnostic Landscape and Organizational Readiness to Implement Next‐Generation Sequencing at Two Childhood Cancer Treatment Centers in Ghana

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Next‐generation sequencing (NGS) has emerged as a promising approach to improve diagnostic accuracy, but its feasibility in low‐ and middle‐income countries remains unknown. This study characterized the diagnostic landscape and assessed organizational readiness for NGS implementation at two childhood cancer treatment centers in Accra ...
Melissa Carvalho, Emmanuella Amoako, Nihad Salifu, Lily Gloria Tagoe, Yaw Bediako, Michelle Hermiston, Catherine Segbefia   +6 more
wiley   +1 more source

Establishment and validation of a prediction model for self-absorption probability of chronic subdural hematoma

Frontiers in Neurology, 2022
BackgroundChronic subdural hematoma (CSDH) is common in elderly people with a clear or occult traumatic brain injury history. Surgery is a traditional method to remove the hematomas, but it carries a significant risk of recurrence and poor outcomes.
Ye Tian, Ye Tian, Ye Tian, Ye Tian, Dong Wang, Dong Wang, Dong Wang, Dong Wang, Xinjie Zhang, Xinjie Zhang, Xinjie Zhang, Xinjie Zhang, Huijie Wei, Huijie Wei, Huijie Wei, Huijie Wei, Yingsheng Wei, Yingsheng Wei, Yingsheng Wei, Yingsheng Wei, Shuo An, Shuo An, Shuo An, Shuo An, Chuang Gao, Chuang Gao, Chuang Gao, Chuang Gao, Jinhao Huang, Jinhao Huang, Jinhao Huang, Jinhao Huang, Jian Sun, Rongcai Jiang, Rongcai Jiang, Rongcai Jiang, Rongcai Jiang, Jianning Zhang, Jianning Zhang, Jianning Zhang, Jianning Zhang   +40 more
doaj   +1 more source

Referral Practices and Utilisation of Paediatric Oncology Physiotherapy Services in Ghana: A Cross‐Sectional Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Physical rehabilitation is highly recognised in improving the quality of life of cancer survivors through prehabilitation, sequelae management and palliative care, yet its integration into routine care in Ghana has not been characterised, leading to potential gaps in service access.
Dorothy Ekua Adjabu, Philip Junior Nyarko, Precious Madzimbe, Kofi Adesi Kyei, Tawagidu Mohammed, Sandra Banini   +5 more
wiley   +1 more source

Possible mechanism and Atorvastatin-based treatment in cupping therapy-related subdural hematoma: A case report and literature review

Frontiers in Neurology, 2022
Subdural hematoma (SDH) is one of the most lethal types of traumatic brain injury. SDH caused by Intracranial Pressure Reduction (ICPR) is rare, and the mechanism remains unclear. Here, we report three cases of SDH that occurred after substandard cupping
Tangtang Xiang, Tangtang Xiang, Xinjie Zhang, Xinjie Zhang, Yingsheng Wei, Yingsheng Wei, Dongyi Feng, Dongyi Feng, Zhitao Gong, Zhitao Gong, Xuanhui Liu, Xuanhui Liu, Jiangyuan Yuan, Jiangyuan Yuan, Weiwei Jiang, Weiwei Jiang, Meng Nie, Meng Nie, Yibing Fan, Yibing Fan, Yupeng Chen, Yupeng Chen, Jiancheng Feng, Jiancheng Feng, Shiying Dong, Shiying Dong, Chuang Gao, Chuang Gao, Jinhao Huang, Jinhao Huang, Rongcai Jiang, Rongcai Jiang   +31 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

PLK4 initiates crosstalk between cell cycle, cell proliferation and macrophages infiltration in gliomas

Frontiers in Oncology, 2022
Tumor immune microenvironment plays an important role in tumorigenesis and metastasis. Polo-like kinases 4 (PLK4) is a crucial regulatory factor in the process of cell cycle, and its abnormal regulation often leads to a variety of diseases including ...
Xiaoyang Zhang, Zesheng Li, Cheng Wei, Lin Luo, Shenghui Li, Junhu Zhou, Hao Liang, Ying Li, Lei Han   +8 more
doaj   +1 more source