Results 31 to 40 of about 24,552,875 (310)

EGFR-vIII downregulated H2AZK4/7AC though the PI3K/AKT-HDAC2 axis to regulate cell cycle progression

Clinical and Translational Medicine, 2020
Background The EGFR-vIII mutation is the most common malignant event in GBM. Epigenetic reprogramming in EGFR-activated GBM has recently been suggested to downregulate the expression of tumour suppressor genes.
Hongyu Zhao, Yunfei Wang, Chao Yang, Junhu Zhou, Lin Wang, Kaikai Yi, Yansheng Li, Qixue wang, Jin Shi, Chunsheng Kang, Liang Zeng   +10 more
doaj   +1 more source

Endoplasmic Reticulum Stress-Associated Neuronal Death and Innate Immune Response in Neurological Diseases

Frontiers in Immunology, 2022
Neuronal death and inflammatory response are two common pathological hallmarks of acute central nervous system injury and chronic degenerative disorders, both of which are closely related to cognitive and motor dysfunction associated with various ...
Mingming Shi, Mingming Shi, Mingming Shi, Yan Chai, Yan Chai, Jianning Zhang, Jianning Zhang, Jianning Zhang, Xin Chen, Xin Chen, Xin Chen   +10 more
doaj   +1 more source

Women in the field of multiple sclerosis: How they contributed to paradigm shifts

Frontiers in Molecular Neuroscience, 2023
History is full of women who made enormous contributions to science. While there is little to no imbalance at the early career stage, a decreasing proportion of women is found as seniority increases.
Andreia Barateiro, Andreia Barateiro, Catarina Barros, Maria V. Pinto, Ana Rita Ribeiro, Ainhoa Alberro, Ainhoa Alberro, Adelaide Fernandes, Adelaide Fernandes   +8 more
doaj   +1 more source

Lipotropin and the Central Nervous System

, 1977
Publisher Summary This chapter deals with the interaction of the lipotropin fragments and related peptides with the central nervous system (CNS). Peptides containing ACTH 4-10, in general, stimulate firing rate, excitability of neurons and neurotransmission, increase cAMP levels, and counteract some morphine-induced CNS effects (inhibition of spinal ...
Gispen, W.H., Ree, J.M. van, Wied, D. de
openaire   +3 more sources

Sarcoidosis of the central nervous system [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1973
Six patients with sarcoidosis of the central nervous system are described. Pathological confirmation was obtained by brain biopsy in two patients and at necropsy in two; in two patients the diagnosis was presumptive and was made on the evidence of multisystem involvement. The symptomatology, methods of diagnosis, and results of treatment are discussed.
A C, Douglas, A F, Maloney
openaire   +2 more sources

Exploration of cerebral vasospasm from the perspective of microparticles

Frontiers in Neuroscience, 2022
Cerebral vasospasm is a frequently encountered clinical problem, especially in patients with traumatic brain injury and subarachnoid hemorrhage. Continued cerebral vasospasm can cause cerebral ischemia, even infarction and delayed ischemic neurologic ...
Yalong Gao, Kai Li, Xiaotian Li, Qifeng Li, Jiwei Wang, Jiwei Wang, Shu Zhang, Jianning Zhang   +7 more
doaj   +1 more source

Actinomycosis of the Central Nervous System :

Japanese Journal of Medical Mycology, 1968
In 1882 Ponfick1) reported the first case of actinomycosis of the central nervous system. Although more than 100 articles have described actinomycosis of the brain and spinal cord, most cases are insufficiently documented to substantiate the diagnosis2).
H, Ikemoto, N, Hazato, F, Matsumura
openaire   +3 more sources

12/15-Lipoxygenase metabolites of arachidonic acid activate PPARγ: a possible neuroprotective effect in ischemic brain

Journal of Lipid Research, 2015
The enzyme 12/15-lipoxygenase (LOX) oxidizes various free fatty acids, including arachidonic acid (AA). In the brain, the principal 12/15-LOX metabolites of AA are 12(S)-HETE and 15(S)-HETE. PPARγ is a nuclear receptor whose activation is neuroprotective
Li Sun, Yan-Wei Xu, Jing Han, Hao Liang, Ning Wang, Yan Cheng   +5 more
doaj   +1 more source

TSPO deficiency promotes the progression of malignant peripheral sheath tumors by regulating the G2/M phase of the cell cycle via CDK1

Scientific Reports
Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive Schwann cell-derived sarcomas that are sporadic or associated with Neurofibromatosis 1 (NF1) gene mutations. Traditional therapies are usually ineffective for treating MPNSTs, so new
Xingnan Zhang, Chenhao Hu, Shengqiao Sun, Chao Guo, Yakun Bu, Zicong Wang, Zewei Liu, Xiaoli Zhang, Dezhi Li, Song Liu   +9 more
doaj   +1 more source

Glucose metabolism: A link between traumatic brain injury and Alzheimer’s disease

Chinese Journal of Traumatology, 2021
Traumatic brain injury (TBI), a growing public health problem, is a leading cause of death and disability worldwide, although its prevention measures and clinical cares are substantially improved.
Xiao-Jian Xu, Meng-Shi Yang, Bin Zhang, Fei Niu, Jin-Qian Dong, Bai-Yun Liu   +5 more
doaj   +1 more source