Results 31 to 40 of about 46,309 (120)

Exploration of cerebral vasospasm from the perspective of microparticles

Frontiers in Neuroscience, 2022
Cerebral vasospasm is a frequently encountered clinical problem, especially in patients with traumatic brain injury and subarachnoid hemorrhage. Continued cerebral vasospasm can cause cerebral ischemia, even infarction and delayed ischemic neurologic ...
Yalong Gao, Kai Li, Xiaotian Li, Qifeng Li, Jiwei Wang, Jiwei Wang, Shu Zhang, Jianning Zhang   +7 more
doaj   +1 more source

Vascularisation of the central nervous system

Mechanisms of Development, 2015
The developing central nervous system (CNS) is vascularised through the angiogenic invasion of blood vessels from a perineural vascular plexus, followed by continued sprouting and remodelling until a hierarchical vascular network is formed. Remarkably, vascularisation occurs without perturbing the intricate architecture of the neurogenic niches or the ...
Tata, Mathew, Ruhrberg, Christiana, Fantin, Alessandro   +2 more
openaire   +3 more sources

12/15-Lipoxygenase metabolites of arachidonic acid activate PPARγ: a possible neuroprotective effect in ischemic brain

Journal of Lipid Research, 2015
The enzyme 12/15-lipoxygenase (LOX) oxidizes various free fatty acids, including arachidonic acid (AA). In the brain, the principal 12/15-LOX metabolites of AA are 12(S)-HETE and 15(S)-HETE. PPARγ is a nuclear receptor whose activation is neuroprotective
Li Sun, Yan-Wei Xu, Jing Han, Hao Liang, Ning Wang, Yan Cheng   +5 more
doaj   +1 more source

Glucose metabolism: A link between traumatic brain injury and Alzheimer’s disease

Chinese Journal of Traumatology, 2021
Traumatic brain injury (TBI), a growing public health problem, is a leading cause of death and disability worldwide, although its prevention measures and clinical cares are substantially improved.
Xiao-Jian Xu, Meng-Shi Yang, Bin Zhang, Fei Niu, Jin-Qian Dong, Bai-Yun Liu   +5 more
doaj   +1 more source

TSPO deficiency promotes the progression of malignant peripheral sheath tumors by regulating the G2/M phase of the cell cycle via CDK1

Scientific Reports
Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive Schwann cell-derived sarcomas that are sporadic or associated with Neurofibromatosis 1 (NF1) gene mutations. Traditional therapies are usually ineffective for treating MPNSTs, so new
Xingnan Zhang, Chenhao Hu, Shengqiao Sun, Chao Guo, Yakun Bu, Zicong Wang, Zewei Liu, Xiaoli Zhang, Dezhi Li, Song Liu   +9 more
doaj   +1 more source

Deep Brain Stimulation for Parkinson’s Disease—A Narrative Review

Biomedicines
Deep brain stimulation (DBS) is an established neurosurgical treatment for Parkinson’s disease (PD), mainly targeting motor symptoms resistant to pharmacological therapy.
Rafał Wójcik, Anna Dębska, Karol Zaczkowski, Bartosz Szmyd, Małgorzata Podstawka, Ernest J. Bobeff, Michał Piotrowski, Paweł Ratajczyk, Dariusz J. Jaskólski, Karol Wiśniewski   +9 more
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HMGB1 affects the progression of neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors through E2F2

Cancer Cell International
Background Malignant peripheral nerve sheath tumors (MPNSTs) represent the most severe complication of neurofibromatosis type 1 (NF1), with limited therapeutic options and poor prognosis.
Shengqiao Sun, Chenhao Hu, Lebao Yu, Dezhi Li, Chao Guo, Song Liu   +5 more
doaj   +1 more source

Atorvastatin combined with dexamethasone in chronic subdural haematoma (ATOCH II): study protocol for a randomized controlled trial

Trials, 2021
Background Chronic subdural haematoma (CSDH) is a common condition in the elderly that often requires neurosurgical management. For small CSDH, evidence has emerged that statins may reduce haematoma volume and improve outcomes, presumably by reducing ...
Rong Cai Jiang, Dong Wang, Shi Guang Zhao, Ren Zhi Wang, De Zhi Kang, Xin Gen Zhu, Zong Mao Zhao, Jun Ji Wei, Ying Huang, Yan Qu, Xiao Chuan Sun, Hong Ming Ji, Xiao Chun Jiang, Jin Fang Liu, Xi De Zhu, Jian Jun Wang, Ye Tian, Chuang Gao, Hui Jie Wei, Shu Zhang, Wei Quan, Shu Yuan Yue, Ping Lei, Xian Li, Li Li Song, Craig S. Anderson, Jian Ning Zhang   +26 more
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Coronaviruses and the central nervous system [PDF]

Journal of NeuroVirology, 2020
Seven coronavirus (CoV) species are known human pathogens: the epidemic viruses SARS-CoV, SARS-CoV-2, and MERS-CoV and those continuously circulating in human populations since initial isolation: HCoV-OC43, HCoV-229E, HCoV-HKU1, and HCoV-NL63. All have associations with human central nervous system (CNS) dysfunction.
openaire   +2 more sources

Possible mechanism and Atorvastatin-based treatment in cupping therapy-related subdural hematoma: A case report and literature review

Frontiers in Neurology, 2022
Subdural hematoma (SDH) is one of the most lethal types of traumatic brain injury. SDH caused by Intracranial Pressure Reduction (ICPR) is rare, and the mechanism remains unclear. Here, we report three cases of SDH that occurred after substandard cupping
Tangtang Xiang, Tangtang Xiang, Xinjie Zhang, Xinjie Zhang, Yingsheng Wei, Yingsheng Wei, Dongyi Feng, Dongyi Feng, Zhitao Gong, Zhitao Gong, Xuanhui Liu, Xuanhui Liu, Jiangyuan Yuan, Jiangyuan Yuan, Weiwei Jiang, Weiwei Jiang, Meng Nie, Meng Nie, Yibing Fan, Yibing Fan, Yupeng Chen, Yupeng Chen, Jiancheng Feng, Jiancheng Feng, Shiying Dong, Shiying Dong, Chuang Gao, Chuang Gao, Jinhao Huang, Jinhao Huang, Rongcai Jiang, Rongcai Jiang   +31 more
doaj   +1 more source