Results 81 to 90 of about 3,023,998 (402)

Central Nervous System Cancers [PDF]

Journal of the National Comprehensive Cancer Network, 2013
Primary and metastatic tumors of the central nervous system are a heterogeneous group of neoplasms with varied outcomes and management strategies. Recently, improved survival observed in 2 randomized clinical trials established combined chemotherapy and radiation as the new standard for treating patients with pure or mixed anaplastic oligodendroglioma ...
Nabors, Louis Burt, Ammirati, Mario, Bierman, Philip J, Brem, Henry, Butowski, Nicholas, Chamberlain, Marc C, DeAngelis, Lisa M, Fenstermaker, Robert A, Friedman, Allan, Gilbert, Mark R, Hesser, Deneen, Holdhoff, Matthias, Junck, Larry, Lawson, Ronald, Loeffler, Jay S, Maor, Moshe H, Moots, Paul L, Morrison, Tara, Mrugala, Maciej M, Newton, Herbert B, Portnow, Jana, Raizer, Jeffrey J, Recht, Lawrence, Shrieve, Dennis C, Sills, Allen K, Tran, David, Tran, Nam, Vrionis, Frank D, Wen, Patrick Y, McMillian, Nicole, Ho, Maria   +30 more
openaire   +5 more sources

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Cadmium promotes ferroptosis in renal tubular epithelial cells by inducing autophagy

陆军军医大学学报, 2022
Objective To investigate the role of ferritinophagy-mediated ferroptosis in renal tubular epithelial cytotoxicity induced by cadmium (Cd) exposure. Methods HK-2 cells were used to construct Cd exposed cell model, and the effects of Cd on ferroptosis ...
LI Min, LI Min, YANG Qian, YANG Qian
doaj   +1 more source

The Brain-Gut-Microbiome Axis. [PDF]

, 2018
Preclinical and clinical studies have shown bidirectional interactions within the brain-gut-microbiome axis. Gut microbes communicate to the central nervous system through at least 3 parallel and interacting channels involving nervous, endocrine, and ...
Kalani, Amir, Martin, Clair R, Mayer, Emeran A, Osadchiy, Vadim   +3 more
core   +2 more sources

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Pan-cancer analysis combined with experiments predicts CTHRC1 as a therapeutic target for human cancers

Cancer Cell International, 2021
Background The function of collagen triple helix repeat containing 1 (CTHRC1) as an oncogene has been reported in a growing number of publications. Bioinformatics methods represent a beneficial approach to examine the mechanism and function of the CTHRC1
Dazhao Peng, Cheng Wei, Xiaoyang Zhang, Shenghui Li, Hao Liang, Xingyu Zheng, Shulong Jiang, Lei Han   +7 more
doaj   +1 more source

Clinical Characteristics of Mild Patients with Breakthrough Infection of Omicron Variant in China after Relaxing the Dynamic Zero COVID-19 Policy

Vaccines, 2023
For SARS-CoV-2 mutants, the effectiveness of the COVID-19 vaccines is still controversial. In this study, we aimed to investigate the clinical characteristics of Omicron-infected patients who completed primary immunization and booster immunization ...
Yingyu He, Fang Zhang, Yan Liu, Zhou Xiong, Shangen Zheng, Wanbing Liu, Lei Liu   +6 more
doaj   +1 more source

Two‐way inhibition of PAX5 transcriptional activity by PAX5::CBFA2T3

FEBS Open Bio, EarlyView.
PAX5::CBFA2T3 (PAX5‐C) is a fusion protein of the B‐cell transcription factor, PAX5, and is found in B‐cell ALL. We propose a putative model of two‐way inhibition of PAX5 transcriptional activity by PAX5‐C. There are two ways of repression by PAX5‐C: DNA‐binding‐dependent way and HDAC‐dependent way, with either being sufficient for the repression. HDAC
Reina Ueno, Aki Terasaki, Yuiko Imai, Yuri Kimura, Yuna Kojima, Misa Irie, Koya Odaira, Mina Noura, Shuichi Okamoto, Takahiko Yasuda, Shinobu Tsuzuki, Hitoshi Kiyoi, Fumihiko Hayakawa   +12 more
wiley   +1 more source

Pan-Cancer Analysis Shows That ALKBH5 Is a Potential Prognostic and Immunotherapeutic Biomarker for Multiple Cancer Types Including Gliomas

Frontiers in Immunology, 2022
BackgroundAlkB homolog 5 (ALKBH5) is a N6-methyladenosine (m6A) demethylase associated with the development, growth, and progression of multiple cancer types.
Cheng Wei, Bo Wang, Dazhao Peng, Xiaoyang Zhang, Zesheng Li, Lin Luo, Yingjie He, Hao Liang, Xuezhi Du, Shenghui Li, Shu Zhang, Zhenyu Zhang, Lei Han, Jianning Zhang   +13 more
doaj   +1 more source

Absence of system xc⁻ on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis [PDF]

, 2017
Background: Multiple sclerosis (MS) is an autoimmune demyelinating disease that affects the central nervous system (CNS), leading to neurodegeneration and chronic disability.
A Banjac, A Castegna, A Chakrabarty, A Dasgupta, A Fogli, A Lau, A Martín, A Massie, A Massie, A Massie, A Mehta, A Prez-Samart¡n, A Tisell, A Vallejo-Illarramendi, AC Rimaniol, Ann Massie, AS Basso, Axel Methner, AY Shih, B Fogal, C Kilkenny, C Larochelle, C Matute, C Nathan, Cathy Jensen, D Bundel De, D Offen, D Piani, D Pitt, D Pitt, D Zhai, DA Baker, DA Hafler, E Merckx, EA McCullagh, Eduard Bentea, Ellen Merckx, F Loria, FN Soria, G Angelini, G Grasselli, G Sulkowski, G Sulkowski, GC Mc, Geert van Loo, Giulia Albertini, H Broholm, H Gmunder, H Hardin-Pouzet, H Sato, H Sato, H Sato, H Sato, H Sato, Hideyo Sato, I Gutcher, IE Morales Pantoja, IR Stojanovic, J Al-Omaishi, J Lewerenz, J Lewerenz, J Lewerenz, J Liefferinge Van, J Newcombe, JA Ellerhorst, Jacques De Keyser, Jan Lewerenz, JF Stover, JJ Geurts, JJ Hendriks, Joeri Van Liefferinge, K Mitosek-Szewczyk, KE Hill, KJ Smith, KS Evonuk, Lauren Deneyer, Lise Verbruggen, LM Sayre, M Kursar, M Naegele, M Ohgoh, M Penkowa, M Vercellino, Magdalena Paterka, Michael Dietrich, O Ciccarelli, O Maguire, O Pampliega, P Gadangi, P Maher, P Sarchielli, P Sarchielli, P Valk van der, P Werner, Pamela Maher, Philipp Albrecht, PW Gout, R Bridges, R Pacheco, R Srinivasan, RJ Bridges, S Bannai, S Chintala, S Licht-Mayer, T Smith, Thomas Demuyser, W Droge, Y Ganor, Y Gilgun-Sherki, Y He, Y He   +110 more
core   +2 more sources