Results 211 to 220 of about 187,996 (306)

Pediatric hospitalization profile in Australia: A longitudinal ecological study, 1998 to 2019. [PDF]

Medicine (Baltimore)
Taybeh EO, Alsharif AA, Naser AY.
europepmc   +1 more source

Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies

Advanced Science, EarlyView.
The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen, Yang Yu, Xiutao Cai, Junhao Lin, Ruirui Liang, Rui Kang, Daolin Tang, Jiao Liu   +7 more
wiley   +1 more source

Clinical Utility of Belay Summit™ Cerebrospinal Fluid Test to Inform Diagnosis and Management of Central Nervous System Cancer-A Single Institution Case Series. [PDF]

Cancers (Basel)
Youssef M, Larson A, Udhane V, Jiang Z, Lim D, Adams JN, Jagadish R, Acevedo A, Domagala BA, Vo SA, Peltier T, Sanchez D, Keo V, Ernst J, Schilter KF, Nie Q, Reddi HV.   +16 more
europepmc   +1 more source

Carboranyl‐Curcuminoids for the Neutron Capture‐Based Treatment of Amyloid Aggregates in Alzheimer's Disease

Advanced Science, EarlyView.
The 10B‐enriched monocarbonyl analog of curcumin (BMAC) 10B‐9 enables site‐specific Boron Neutron Capture Therapy (BNCT) on amyloid‐β (Aβ) fibrils. Neutron irradiation induces histidine oxidation and fibril destabilization, as revealed by 1H‐NMR and FESEM analyses.
Sebastiano Micocci, Stefano Parisotto, Diego Alberti, Alberto Lanfranco, Valeria Bitonto, Polyssena Renzi, Martina Salmi, Federica Dal Bello, Katiuscia Pagano, Laura Ragona, Nicoletta Protti, Annamaria Deagostino, Simonetta Geninatti Crich   +12 more
wiley   +1 more source

Comparative safety of denosumab and romosozumab in osteoporosis: an analysis based on the FDA adverse event reporting system database. [PDF]

Front Med (Lausanne)
Sun J, Lunzhu C, Wu Y, Li J.
europepmc   +1 more source

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

Advanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun, Xu Yang, Wenchao Jiang, Chengbo Ji, Yingying Wu, Haoyu Sun, Xinyou Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Junjie Zhao, Yuanyuan Ruan, Haojie Li, Xuefei Wang   +13 more
wiley   +1 more source

Right Temporal Lobe Tuberculoma Presenting as Seizures in a Patient With Pulmonary Tuberculosis. [PDF]

Am J Case Rep
Rajanna S, Prasad S, Shaji M, Mehta K, Hassoun P, McSharry D, Lo A, Elias S, Tran HH.   +8 more
europepmc   +1 more source

Multinodular and vacuolating neuronal tumors in epilepsy: dysplasia or neoplasia? [PDF]

, 2018
An S, Aronica E., Bongaarts A, Bucur S, Honavar M, Jacques T, Jäger HR, Liu J, Marsdon D, McEvoy A, Miserocchi A, Newman F, Paradiso B, Reeves C, Reinten RJ, Somani A, Thom M, Thorne L   +17 more
core  

Beyond Extracellular Vesicle (EV) Hype: Practical Solutions and Remaining Hurdles in EV Research, Manufacturing, and Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale mediators of intercellular communication with diverse molecular cargoes that reflect their cell of origin. Advances in isolation, detection, and single‐particle analytics have revealed increasing molecular and functional heterogeneity, while exposing limitations in how EV identity and activity are ...
David J. Lundy, Zoe L. Chau, Sheng‐You Chen, Nanami Fujisawa, John J. Hill, Barnett M. Hsu, Joanne K. Liu, Karol W. Mai, James J. Lai   +8 more
wiley   +1 more source

The public health burden of nervous system tumors in Anambra State, Nigeria necessitates strategic resource allocation. [PDF]

Sci Rep
Odita AO, Menkiti FE, Ofiaeli OC, Modekwe VI, Chukwurah SN.   +4 more
europepmc   +1 more source