Results 61 to 70 of about 44,761 (349)
Poisoning with illicit substances: toxicology for the anaesthetist [PDF]
, 2013 The consumption of illicit substances represents a considerable threat to the health and wellbeing of particular sectors of our communities. Hospitalisation is sometimes required for the treatment of the direct toxic effects of the drugs as well as for ...
Irwin, MG, Wong, GTC
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Einstein (São Paulo), 2019 Objective To estimate the prevalence of and factors associated with the use of methylphenidate for cognitive enhancement among undergraduate students.
Raissa Carolina Fonseca Cândido +3 more
doaj +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Metoprolol treatment of dual cocaine and bupropion cardiovascular and central nervous system toxicity [PDF]
Clinical and Experimental Emergency Medicine, 2019 Cardiovascular and central nervous system (CNS) toxicity, including tachydysrhythmia, agitation, and seizures, may arise from cocaine or bupropion use.
John R. Richards +3 more
doaj +1 more source
Energy drinks - product ingredients and their potential toxicity
Journal of Education, Health and Sport, 2023 Energy drinks (NE) are popular stimulants among adolescents and adults. They are commercial, advertised, widely available products that contain increased amounts of caffeine, and are designed to reduce feelings of fatigue in favor of increased mental ...
Michał Jakub Sekuła +6 more
doaj +1 more source
TMC4 localizes to multiple taste cell types in the mouse taste papillae
FEBS Open Bio, EarlyView.Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata +6 more
wiley +1 more source
Retrospective Review of Trend in Modafinil Overexposures Reported to American Poison Information Centers [PDF]
Asia Pacific Journal of Medical Toxicology, 2014 Background:Modafinil, a non-amphetamine central nervous system stimulant, is a wakefulness-promoting agent indicated for use in shift work sleep disorder, narcolepsy, and obstructive sleep apnea. The trend in modafinil overexposure over a ten-year period
Kristin Bohnenberger, Edward Krenzelok
doaj
Frontiers in Pediatrics, 2014 It is estimated that 2-3% of children in the US have hypertension (HTN) and 8% of children ages 4-17 carry the diagnosis of Attention Deficit Hyperactivity Disorder (ADHD).
Susan M Hailpern +6 more
doaj +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source