Results 71 to 80 of about 16,470 (273)

Genotype-Phenotype Correlations in Children with HHT [PDF]

, 2020
Hereditary hemorrhagic telangiectasia (HHT), a rare autosomal dominant disease mostly caused by mutations in three known genes (, , and ), is characterized by the development of vascular malformations (VMs).
Whitehead, Kevin J., Whitehead, Kevin, Giuseppe Latino, Doris Lin, Helen Kim, Lin, Doris, McWilliams, Justin P, Faughnan, Marie E, Jamie McDonald, Andrew White, Chakinala, Murali M., Alexandra Kilian, Latino, Giuseppe A., Felix Ratjen, Justin McWilliams, Latino, Giuseppe A, Kim, Helen, Lawton, Michael T, Dewi Clark, Henderson, Katharine, Faughnan, Marie E., James Gossage, McDonald, Jamie, Pollak, Jeffrey, Clark, Dewi, Gossage, James R, White, Andrew J., Whitehead, Kevin J, Katharine Henderson, Michael Lawton, Jeffrey Pollak, Kilian, Alexandra, White, Andrew J, the Brain Vascular Malformation Consortium HHT Investigator Group, the Brain Vascular Malformation Consortium HHT Investigator Group,, Ratjen, Felix, Kevin Whitehead, Gossage, James R., McWilliams, Justin P., Murali Chakinala, Lawton, Michael T., Chakinala, Murali M, Marie Faughnan   +42 more
core   +1 more source

Toward Wireless Implantable Robotic Systems Driven by Magnetic Field for Personalized Therapy

Advanced Robotics Research, EarlyView.
Robotic materials are playing an increasingly vital role in enabling sensing and actuation at small scales. This perspective highlights recent advances in magnetic materials and magnetically actuated devices for wireless sensing, actuation, and energy harvesting toward implantable robotic systems for closed‐loop therapy.
Yusheng Wang, Ruijian Ge, Xiaoguang Dong
wiley   +1 more source

Involvement of Microglia in the Pathophysiology of Intracranial Aneurysms and Vascular Malformations—A Short Overview

, 2021
Aneurysms and vascular malformations of the brain represent an important source of intracranial hemorrhage and subsequent mortality and morbidity. We are only beginning to discern the involvement of microglia, the resident immune cell of the central ...
Ioan Alexandru Florian, Teodora Larisa Timis, Ioan Stefan Florian, Sergiu Susman   +3 more
core   +1 more source

Hybrid Continuum Robot Designs and Architectures for Healthcare Applications

Advanced Robotics Research, EarlyView.
Hybrid continuum robots represent an emerging class of flexible manipulators that blend materials, structures, and actuation concepts from the established fields of soft and continuum robotics. This review introduces an accessible framework to distinguish key hybridization approaches, surveys current designs aimed at complex clinical applications, and ...
Burak Ozdemir, Muhammad A. Khalid, Manish Chauhan, Pietro Valdastri, James H. Chandler   +4 more
wiley   +1 more source

Estimating the Global Incidence of Aneurysmal Subarachnoid Hemorrhage: A Systematic Review for Central Nervous System Vascular Lesions and Meta-Analysis of Ruptured Aneurysms

, 2018
There is increasing acknowledgement that surgical care is important in global health initiatives. In particular, neurosurgical care is as limited as 1 per 10 million people in parts of the world. We performed a systematic literature review to examine the
Joshua D. Hughes, Dewan, Michael C, Kato, Yoko, Park, Kee B, Ronnie Baticulon, Abbas Rattani, Morcos, Jacques J, Kamila M. Bond, Rania A. Mekary, Kee B. Park, Mekary, Rania A, Hughes, Joshua D, Michael C. Dewan, Yoko Kato, Jacques J. Morcos, Rattani, Abbas, Baticulon, Ronnie, Bond, Kamila M, Hildo Azevedo-Filho, Azevedo-Filho, Hildo   +19 more
core   +1 more source

GPR124 Alleviates Blood–Brain Barrier Disruption by Enhancing Microvascular Endothelial Function after Traumatic Brain Injury

Advanced Science, EarlyView.
Our study reveals the protective role of GPR124 in maintaining BBB integrity and promoting neurological recovery following TBI. It makes a significant contribution by uncovering a novel molecular interaction between GPR124 and FGFBP1 and linking this to activation of the Wnt/β‐catenin signaling pathway in vascular repair mechanisms.
Chen Wang, Lin Cai, Qiuyuan Gong, Yang Yang, Yuqing Liang, Xinyu Niu, Lai Wei, Ze Liu, Shengju Wu, Yinghui Men, Yaohui Tang, Jun Ding, Hengli Tian, Hao Chen   +13 more
wiley   +1 more source

A Novel CCM2 Gene Mutation Associated With Cerebral Cavernous Malformation

Frontiers in Neurology, 2020
Cerebral cavernous malformations (CCMs) are the second most prevalent type of vascular malformation within the central nervous system. CCMs occur in two forms—sporadic and familial—the latter of which has an autosomal dominant mode of inheritance with ...
Lipeng Yang, Jian Wu, Jing Zhang
doaj   +1 more source

Progressive late-onset of cutaneous angiomatosis as possible sign of cerebral cavernous malformations

, 2013
Cerebral cavernous malformations (CCM) comprise enlarged capillary cavities in the central nervous system, with possible retinal or cutaneous vascular malformations.
Bianchi, L, Chimenti, S, Orlandi, A, Diluvio, L, Campione, E, BIANCHI, LUCA, Stefani, A Di, Terrinoni, A, ORLANDI, AUGUSTO, DI STEFANI, ALESSANDRO   +9 more
core   +1 more source

A novel CCM1 mutation associated with multiple cerebral and vertebral cavernous malformations [PDF]

, 2014
Background: Cerebral cavernous malformations are relatively rare vascular disorders that may affect any part of the central nervous system. This presentation has been associated with heterozygous mutations in CCM1/KRIT1, CCM2/malcavernin and CCM3/PDCD10.
D. Ronchi, N. Bresolin, G.P. Comi, Naghia Ahmed, S. Corti, Silvia Lanfranconi, Nereo Bresolin, Stefania Corti, Paola Basilico, Giacomo Pietro Comi, V. Civelli, P. Basilico, Vittorio Civelli, Dario Ronchi, S. Lanfranconi, N. Ahmed   +15 more
core   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source