Results 91 to 100 of about 38,605 (289)

Adaptive-Frequency Central Pattern Generator with Multi-Scale Feedback for Dynamic Quadruped Locomotion

Actuators
This paper studies a MuJoCo-based locomotion framework that couples an adaptive-frequency central pattern generator (AFCO-CPG) with single rigid-body dynamics model predictive control (MPC) for the RENS Q1 quadruped with elastic parallel knee joints ...
Rui Qin, Yaguang Zhu, Haipeng Qin, Xiaoyu Zhang   +3 more
doaj   +1 more source

Atoh1-dependent rhombic lip neurons are required for temporal delay between independent respiratory oscillators in embryonic mice

eLife, 2014
All motor behaviors require precise temporal coordination of different muscle groups. Breathing, for example, involves the sequential activation of numerous muscles hypothesized to be driven by a primary respiratory oscillator, the preBötzinger Complex ...
Srinivasan Tupal, Wei-Hsiang Huang, Maria Cristina D Picardo, Guang-Yi Ling, Christopher A Del Negro, Huda Y Zoghbi, Paul A Gray   +6 more
doaj   +1 more source

General Principles of Rhythmogenesis in Central Pattern Generator Networks [PDF]

, 2010
The cellular and ionic mechanisms that generate the rhythm in central pattern generator (CPG) networks for simple movements are not well understood. Using vertebrate locomotion, respiration and mastication as exemplars, I describe four main principles of rhythmogenesis: (1) rhythmogenic ionic currents underlie all CPG networks, regardless of whether ...
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Benchmarking Open-Loop Central Pattern Generator Controllers for Lower-Limb Exoskeleton Walking Trajectories

IEEE Access
Central Pattern Generators (CPGs) enable rhythmic, biologically inspired control of robotic locomotion. This study presents a comparative evaluation of three CPG models: Hopf, Matsuoka, and sinusoidal implemented on a simplified lower-limb exoskeleton ...
Hod Pery, Tal Ben Eli, Eldad Holdengreber   +2 more
doaj   +1 more source

Dopamine: A parallel pathway for modulation of locomotor networks

Frontiers in Neural Circuits, 2014
The spinal cord contains networks of neurons that can produce locomotor patterns. To readily respond to environmental conditions, these networks must be flexible yet at the same time robust.
Simon eSharples, Kathrin eKoblinger, Jennifer eHumphreys, Patrick John Whelan   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Imaging fictive locomotor patterns in larval Drosophila

, 2015
S.R.P. was supported by a Newton International Fellowship (Royal Society) and a Junior Fellowship (Janelia Research Campus, Howard Hughes Medical Institute). T.G.B. was supported by a Medical Research Council (UK) PhD grant. J.B. was supported by a Henry
Pulver, Stefan, Taylor, Adam, Bayley, Timothy, Michael Bate (70275), Bate, Michael, Berthold Hedwig (359009), Hedwig, Berthold, Stefan R Pulver (16281800), Berni, Jimena, Jimena Berni (7875149), Timothy G Bayley (16281803), Adam L Taylor (16281806)   +11 more
core   +1 more source

A Single Central Pattern Generator for the Control of a Locomotor Rolling Wave in Mollusc Aplysia. [PDF]

Research (Wash D C), 2023
Wang HY, Yu K, Yang Z, Zhang G, Guo SQ, Wang T, Liu DD, Jia RN, Zheng YT, Su YN, Lou Y, Weiss KR, Zhou HB, Liu F, Cropper EC, Yu Q, Jing J.   +16 more
europepmc   +1 more source