Results 121 to 130 of about 141,503 (294)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Gait generation for a simulated hexapod robot : a nonlinear dynamical systems approach [PDF]

, 2010
The capacity of walking in a wide variety of terrains is one of the most important features of hexapod insects. In this paper we describe a bio-inspired controller able to generate locomotion and reproduce the different type of gaits for an hexapod ...
Campos, R., Matos, Vítor, Oliveira, Miguel, Santos, Cristina   +3 more
core  

Sugawara-type constraints in hyperbolic coset models

, 2009
In the conjectured correspondence between supergravity and geodesic models on infinite-dimensional hyperbolic coset spaces, and E10/K(E10) in particular, the constraints play a central role.
A. Kleinschmidt, A. Kleinschmidt, A. Kleinschmidt, A. Kleinschmidt, A. Kleinschmidt, A.Y. Morozov, Axel Kleinschmidt, B.S. DeWitt, F. Riccioni, H. Nicolai, H. Sugawara, Hermann Nicolai, I. Schnakenburg, I. Schnakenburg, J. Brown, K. Bardakçi, L.A. Forte, L.J. Romans, M. Henneaux, M.B. Halpern, M.R. Gaberdiel, P. Goddard, P. Goddard, P.C. West, P.C. West, P.C. West, R.W. Gebert, T. Damour, T. Damour, T. Damour, T. Damour, T. Damour, T. Damour, Thibault Damour, V. Kac, V.G. Kac   +35 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

General Principles of Rhythmogenesis in Central Pattern Generator Networks [PDF]

, 2010
The cellular and ionic mechanisms that generate the rhythm in central pattern generator (CPG) networks for simple movements are not well understood. Using vertebrate locomotion, respiration and mastication as exemplars, I describe four main principles of rhythmogenesis: (1) rhythmogenic ionic currents underlie all CPG networks, regardless of whether ...
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Neural Control of Interlimb Oscillations II. Biped and Quadruped Gaits and Bifurications [PDF]

, 1994
Behavioral data concerning animal and human gaits and gait transitions are simulated as emergent properties of a central pattern generator (CPG) model. The CPG model is a version of the Ellias-Grossberg oscillator.
Cohen, Michael A., Grossberg, Stephen, Pribe, Christopher A.   +2 more
core   +1 more source

Central pattern generator [PDF]

Spinal Cord, 1995
openaire   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source