Results 41 to 50 of about 29,319 (267)

Treatment of Central Precocious Puberty [PDF]

Journal of the Endocrine Society, 2019
Long-acting analogs of GnRH (GnRHas) have been the gold-standard treatment of central precocious puberty (CPP) worldwide and have an enviable track record of safety and efficacy. Recent years have witnessed much growth in the availability of longer-acting and sustained-release forms of GnRHas.
openaire   +2 more sources

Aberrant Notch Signaling Pathway as a Potential Mechanism of Central Precocious Puberty

International Journal of Molecular Sciences, 2022
The Notch signaling pathway is highly conserved during evolution. It has been well documented that Notch signaling regulates cell proliferation, migration, and death in the nervous, cardiac, and endocrine systems.
Y. Shim, Hae-sang Lee, J. Hwang
semanticscholar   +1 more source

Substance P regulates puberty onset and fertility in the female mouse [PDF]

, 2015
Puberty is a tightly regulated process that leads to reproductive capacity. Kiss1 neurons are crucial in this process by stimulating GnRH, yet how Kiss1 neurons are regulated remains unknown. Substance P (SP), an important neuropeptide in pain perception,
Carroll, R.S., Gill, J.C., Kaiser, U.B., Maguire, C.A., Navarro, V.M., Simavli, Serap Aynur, Thompson, I.R., Wolfe, A.   +7 more
core   +1 more source

Endocrinologic disorders and optic pathway gliomas in children with neurofibromatosis type 1 [PDF]

, 1997
Objective. To establish the prevalence of endocrinologic disorders in children with neurofibromatosis type 1 (NF1) and the relationship between these disorders and cerebral abnormalities on magnetic resonance imaging. Design.
Cnossen, M.H. (Marjon), Cooiman, L.C.M.G. (Linda C. M. G.), Goede-Bolder, A. (Arja) de, Halley, D. (Dicky), Muinck Keizer-Schrama, S.M.P.F. (Sabine) de, Niermeijer, M.F. (Martinus), Oranje, A.P. (Arnold), Simonsz, H.J. (Huib), Stam, E.N. (Esther N.), Stroink, H. (Hans)   +9 more
core   +1 more source

Central Precocious Puberty in Italian Boys: Data From a Large Nationwide Cohort

Journal of Clinical Endocrinology and Metabolism
Context There are only a few nationwide studies on boys with central precocious puberty (CPP) and the last Italian study is a case series of 45 boys that dates back to 2000.
Alessandra Cassio, Gloria Marescotti, T. Aversa, M. Salerno, G. Tornese, M. Stancampiano, G. Tuli, M. Faienza, P. Cavarzere, D. Fava, M. Parpagnoli, P. Bruzzi, A. Ibba, V. Calcaterra, C. Mameli, A. Grandone, V. Cherubini, V. Assirelli, Francesca Franchina, D. Capalbo, R. Mase, Gianluca Tamaro, Julia Cavasin, J. Munarin, Gianni Russo, M. Wasniewska   +25 more
semanticscholar   +1 more source

Implicating factors in the increase in cases of central precocious puberty (CPP) during the COVID-19 pandemic: Experience of a tertiary centre of pediatric endocrinology and review of the literature

Frontiers in Endocrinology, 2022
Sexual development is a complex mechanism activated by the hypothalamic-pituitary-gonadal axis. Over the last one hundred years there has been a decline in the age at puberty onset in industrialised countries.
C. Barberi, V. Di Natale, V. Assirelli, L. Bernardini, E. Candela, A. Cassio   +5 more
semanticscholar   +1 more source

Bird's-eye view of GnRH analog use in a pediatric endocrinology referral center [PDF]

, 2015
OBJECTIVE: Gonadotropin-releasing hormone analogs (GnRHa) are standard of care for the treatment of central precocious puberty (CPP). GnRHa have also been prescribed in other clinical settings with the hope of increasing adult stature, although ...
Eugster, Erica A., Greene, Ariana, Lewis, Katherine, Watson, Sara E.   +3 more
core   +1 more source

Evo-devo of human adolescence: beyond disease models of early puberty [PDF]

, 2013
Despite substantial heritability in pubertal development, much variation remains to be explained, leaving room for the influence of environmental factors to adjust its phenotypic trajectory in the service of fitness goals.
A Templeton, AB Arquitt, AB Migliano, AK Pesonen, AS Parent, B Bogin, B Campbell, BH Smith, BJ Ellis, BJ Ellis, BJ Ellis, BJ Ellis, BS Zemel, C Ankarberg Lindgren, C Cooper, C Tardieu, CC Chen, CL Sisk, F Deng, GB Cutler Jr, GB Muller, GE Weisfeld, J Belsky, J Belsky, J Belsky, J Belsky, J Belsky, J Belsky, J Belsky, J Belsky, J Belsky, J Bowlby, J Bowlby, J James, J Tinggaard, Jay Belsky, JC Wingfield, JL Locke, JM Tither, KB Simondon, KK Ong, KK Ong, KO Klein, L Aksglaede, LA Proos, M Celio, M Del Giudice, M Krstevska-Konstantinova, M Mead, M Suzuki, ME Pembrey, MR Palmert, N Howell, NM Cameron, PD Gluckman, PD Kroboth, PJ Hunt, RG Westendorp, S White, SB Manuck, SC Stearns, W Arlt, W Copeland, WT Boyce, Z Hochberg, Z Hochberg, Z Hochberg, Z Hochberg, Z Hochberg, Ze'ev Hochberg   +69 more
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The Role of DLK1 Deficiency in Central Precocious Puberty and Association with Metabolic Dysregulation

Hormone Research in Paediatrics
Introduction: Precocious puberty is defined as the appearance of secondary sexual characteristics before the age of 8 years in girls and 9 years in boys.
Francesco d’Aniello, Katia Mariniello, Yasmin Al Sayed, Karishma Bhavsar, Jordan E Read, L. Guasti, Sasha R. Howard   +6 more
semanticscholar   +1 more source

A review of the genetics and epigenetics of central precocious puberty

Frontiers in Endocrinology, 2022
Gonadotrophin dependent sexual precocity, commonly referred to as central precocious puberty (CPP), results from a premature reactivation of the hypothalamic-pituitary-gonadal (HPG) axis before the normal age of pubertal onset.
J. Moise-Silverman, L. Silverman
semanticscholar   +1 more source