Results 141 to 149 of about 149 (149)

Central tolerance: Clonal deletion or clonal arrest?

European Journal of Immunology, 1994
AbstractStudies in various experimental animals have shown that developing T cells with specificity for self antigens can be prevented from maturation at an early stage of development. While several in vitro and in vivo experiments have shown that the mechanism of silencing autospecific T cells is the deletion of immature CD4+8+ thymocytes other ...
Pawel Kisielow, Harald von Boehmer, Wojciech Swat   +2 more
openaire   +3 more sources

Tissue Tolerance: Central Nervous System

Radiology, 1968
IN 1958 LAMPE (13) surveyed the experience to date with radiation tolerance of the central nervous system. He concluded that, as of that time, precise radiation tolerance limits of the central nervous system were not known for clinical radio-therapeutic practice. This still holds true today.
openaire   +3 more sources

Aspects of Tolerability of Centrally Acting Antihypertensive Drugs

Journal of Cardiovascular Pharmacology, 1996
Traditional centrally acting antihypertensives have been associated with a high incidence of adverse effects and are no longer recommended as first-line therapy. The newer imidazoline receptor agonists must overcome this reputation if they are to gain recognition as potential first-line agents for hypertension.
J. Webster, H.-F. Koch
openaire   +2 more sources

Centrally acting vasopressin contributes to endotoxin tolerance

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1990
Repeated daily intravenous injections of bacterial endotoxin induce a refractory state to their usual pyrogenic effects. The neuropeptide arginine vasopressin (AVP) has been implicated in natural fever suppression and may be involved in the process of pyrogenic tolerance to intravenous endotoxin.
M. F. Wilkinson, N. W. Kasting
openaire   +3 more sources

Antigen presentation for central tolerance induction

Nature Reviews Immunology
The extent of central T cell tolerance is determined by the diversity of self-antigens that developing thymocytes 'see' on thymic antigen-presenting cells (APCs). Here, focusing on insights from the past decade, we review the functional adaptations of medullary thymic epithelial cells, thymic dendritic cells and thymic B cells for the purpose of ...
Ludger, Klein, Elisabetta, Petrozziello
openaire   +2 more sources

Receptor editing in lymphocyte development and central tolerance

Nature Reviews Immunology, 2006
The specificities of lymphocytes for antigen are generated by a quasi-random process of gene rearrangement that often results in non-functional or autoreactive antigen receptors. Regulation of lymphocyte specificities involves not only the elimination of cells that display 'unsuitable' receptors for antigen but also the active genetic correction of ...
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CCL2 Chemokine in Central Tolerance

Scandinavian Journal of Immunology, 2014
Cedile, O., Lobner, M., Toft-Hansen, H., Frank, I., Wlodarczyk, A., Irla, M., Owens, T.   +6 more
openaire   +1 more source

[Central tolerance].

Nihon rinsho. Japanese journal of clinical medicine, 2005
openaire   +1 more source

Biologic Tolerance of the Central Nervous System to Metrizamide

Acta Radiologica. Diagnosis, 1973
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