Results 141 to 150 of about 1,358,589 (334)

Ikaros is a principal regulator of Aire⁺ mTEC homeostasis, thymic mimetic cell diversity, and central tolerance. [PDF]

Sci Immunol, 2023
Sin JH, Sucharov J, Kashyap S, Wang Y, Proekt I, Liu X, Parent AV, Gupta A, Kastner P, Chan S, Gardner JM, Ntranos V, Miller CN, Anderson MS, Schjerven H, Waterfield MR.   +15 more
europepmc   +1 more source

Medullary Thymic Epithelial Stem Cells Maintain a Functional Thymus to Ensure Lifelong Central T Cell Tolerance [PDF]

, 2014
Miho Sekai, Yoko Hamazaki, Nagahiro Minato   +2 more
openalex   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

CTLA-4 on thymic epithelial cells complements Aire for T cell central tolerance. [PDF]

Proc Natl Acad Sci U S A, 2022
Michelson DA, Benoist C, Mathis D.
europepmc   +1 more source

The early steps of drought response mediated by ABA: evolutionary and molecular mechanism of Coffea canephora PYR/PYL/RCAR receptors [PDF]

, 2014
The abscisic acid (ABA) is a vital phytohormone synthesized in roots and leaves, acting as central regulator involved in plant responses against abiotic stress, such as drought.
Andrade, Alan Carvalho, Aquino, Sinara O., Bocs, Stéphanie, Carneiro, Fernanda A, Costa, Tatiana S., Cotta, Michelle G., Marraccini, Pierre, Rego, Erica C.S., This, Dominique   +8 more
core  

High tolerance of Chaetomorpha sp. to salinity and water temperature enables survival and growth in stagnant waters of central Thailand [PDF]

, 2015
Isao Tsutsui, Tatsuo Miyoshi, Dusit Aue-umneoy, Jaruwan Songphatkaew, Chonlada Meeanan, Sirimas Klomkling, Halethichanok Sukchai, Piyarat Pinphoo, Iori Yamaguchi, Monthon Ganmanee, Yukio Maeno, Kaoru Hamano   +11 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Medullary Thymic Epithelial Cells and Central Tolerance in Autoimmune Hepatitis Development: Novel Perspective from a New Mouse Model [PDF]

, 2015
Konstantina Alexandropoulos, Anthony Bonito, Erica J Weinstein, Olivier Herbin   +3 more
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Deciphering crop-specific rhizobacteriome assembly in cotton, sorghum, and soybean under hot semi-arid field conditions in Texas

Environmental Microbiome
Background Different crops may recruit specific rhizosphere microbiomes that support their survival under unfavorable conditions, including hot semi-arid climates.
Mostafa Abdelrahman, Sudisha Jogaiah, Mohamed Abdelmoteleb, Mohamed Fokar, Henry T. Nguyen, Lam-Son Phan Tran   +5 more
doaj   +1 more source