Regulation of Foxo1 expression is critical for central B cell tolerance and allelic exclusion
Cell ReportsSummary: Resolving the molecular mechanisms of central B cell tolerance might unveil strategies that prevent autoimmunity. Here, using a mouse model of central B cell tolerance in which Forkhead box protein O1 (Foxo1) is either deleted or over-expressed ...
Megan R. McCaleb +4 more
doaj +1 more source
Genetic Modifiers of Thymic Selection and Central Tolerance in Type 1 Diabetes. [PDF]
Front Immunol, 2022 Kissler S.
europepmc +1 more source
Respect as the Ethic of the Open Society [PDF]
, 2006 Karl Popper’s description of the open society in terms of respect, rather than mere tolerance, appears to be highly relevant today. Although he never explicitly addressed the issues of multiculturalism and valuepluralism in contemporary societies ...
Gattei, Stefano
core
Hapten-Specific Tolerance Induced by Hapten Conjugates of
, 1978 David H. Katz, Yves Borel
openalex +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Impaired central tolerance induces changes in the gut microbiota that exacerbate autoimmune hepatitis. [PDF]
J Autoimmun, 2022 Centa M +7 more
europepmc +1 more source
Autoimmune regulator gene, Aire, is involved in central tolerance to the
, 2014 Asako Tagawa +3 more
openalex +1 more source
Protein O‐glycosylation in the Bacteroidota phylum
FEBS Open Bio, EarlyView.Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns +2 more
wiley +1 more source
The adaptation model of immunity: Is the goal of central tolerance to eliminate defective T cells or self-reactive T cells? [PDF]
Scand J Immunol, 2022 Manjili MH.
europepmc +1 more source
Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node
FEBS Open Bio, EarlyView.The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner +6 more
wiley +1 more source