Results 161 to 170 of about 1,358,589 (334)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Adeno-associated virus-mediated gene transfer of arginine decarboxylase to the central nervous system prevents opioid analgesic tolerance

Frontiers in Pain Research
Agmatine, a decarboxylated form of L-arginine, prevents opioid analgesic tolerance, dependence, and self-administration when given by both central and systemic routes of administration.
Caroline C. Churchill, Cristina D. Peterson, Cristina D. Peterson, Cristina D. Peterson, Kelley F. Kitto, Kelsey R. Pflepsen, Lalitha R. Belur, R. Scott McIvor, Lucy Vulchanova, George L. Wilcox, George L. Wilcox, George L. Wilcox, Carolyn A. Fairbanks, Carolyn A. Fairbanks, Carolyn A. Fairbanks   +14 more
doaj   +1 more source

Disruption of thymic central tolerance by infection with murine roseolovirus induces autoimmune gastritis. [PDF]

J Exp Med, 2022
Bigley TM, Yang L, Kang LI, Saenz JB, Victorino F, Yokoyama WM.   +5 more
europepmc   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source

B-cell intrinsic and extrinsic signals that regulate central tolerance of mouse and human B cells. [PDF]

Immunol Rev, 2022
Pelanda R, Greaves SA, Alves da Costa T, Cedrone LM, Campbell ML, Torres RM.   +5 more
europepmc   +1 more source

Investigation into Mobile Learning Framework in Cloud Computing Platform [PDF]

, 2014
—Cloud computing infrastructure is increasingly used for distributed applications. Mobile learning applications deployed in the cloud are a new research direction.
Joan, Lu, Wei, Guo
core  

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Identification and characterization of genes involved in ABA perception and signal transduction in Coffea spp : S02P13 [PDF]

, 2013
The Coffea genus represents a major agricultural commodity in world trade. Nowadays, drought and elevated temperatures are the major climatic limitations for coffee production.
Andrade, Alan Carvalho, Bocs, Stéphanie, Cotta, Michelle G., Dereeper, Alexis, Lashermes, Philippe, Leroy, Thierry, Marraccini, Pierre, This, Dominique   +7 more
core  

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Antibody-Mediated Targeting of a Hybrid Insulin Peptide Toward Neonatal Thymic Langerin-Positive Cells Enhances T-Cell Central Tolerance and Delays Autoimmune Diabetes. [PDF]

Diabetes, 2022
Lin Y, Perovanovic J, Kong Y, Igyarto BZ, Zurawski S, Tantin D, Zurawski G, Bettini M, Bettini ML.   +8 more
europepmc   +1 more source