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Brain sensory network activity underlies reduced nociceptive initiated and nociplastic pain via acupuncture in fibromyalgia. [PDF]

open access: yesCommun Med (Lond)
Sridhar A   +7 more
europepmc   +1 more source

Central tolerance in T cells, what’s new?

open access: hybrid
Alex Jhonier Imbachí Salamanca   +1 more
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Central Tolerance Induction

2013
A critical function of the thymus is to help enforce tolerance to self. The importance of central tolerance in preventing autoimmunity has been enlightened by a deeper understanding of the interactions of developing T cells with a diverse population of thymic antigen presenting cell populations.
Maria L, Mouchess, Mark, Anderson
openaire   +2 more sources

A CENTRAL ROLE FOR CENTRAL TOLERANCE

Annual Review of Immunology, 2006
Recent elucidation of the role of central tolerance in preventing organ-specific autoimmunity has changed our concepts of self/nonself discrimination. This paradigmatic shift is largely attributable to the discovery of promiscuous expression of tissue-restricted self-antigens (TRAs) by medullary thymic epithelial cells (mTECs).
Bruno, Kyewski, Ludger, Klein
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Central tolerance: good but imperfect

Immunological Reviews, 2006
Summary:  T‐cell development is a highly coordinated process that depends on interactions between thymocytes, thymic epithelium, and bone marrow (BM)‐derived dendritic cells (DCs). Before entering the peripheral T‐cell pool, thymocytes are subject to negative selection, a process that eliminates (or deletes) T cells with high affinity toward self ...
Alena M, Gallegos, Michael J, Bevan
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Tolerance to centrally administered phenobarbital

Biochemical Pharmacology, 1976
Abstract Rats with permanent indwelling cerebral ventricular cannulae were shown to lose their righting reflex in response to centrally injected phenobarbital in a dose-related manner. Administration of four daily injections of 800 μg each over a 4- to 5-day period produced a gradual tolerance to the hypnotic effect, which was reversible after ...
M J, Mycek, H E, Brezenoff
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