Results 291 to 300 of about 1,358,589 (334)
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Chimerism and central tolerance
Current Opinion in Immunology, 1996With adequate depletion or inactivation of the pre-existing immune system and establishment of conditions permitting donor hematopoietic stem cell engraftment, a robust state of central deletional tolerance to allogeneic or xenogeneic donors can be induced.
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Cross-tolerance to centrally injected barbiturates
European Journal of Pharmacology, 1979Hypnotic responses to intracerebroventricular (i.c.v) injections of either barbital, pentobarbital, R(-) and S(+) mephorbarbital, or racemic metharbital were compared to those produced by phenobarbital. Dose--response relationships were obtained for all except S(+) mephorbarbital and metharbital. Chronic i.c.v.
W H, Lyness, H E, Brezenoff, M J, Mycek
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The Thymus and Central Tolerance
Hormone and Metabolic Research, 1996Thymic selection programs T lymphocytes to tolerate self antigens but respond to foreign antigens. The mechanisms involved in self tolerance induction are discussed.
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International Reviews of Immunology, 1995
The immune system is constructed to tolerate self antigens but give vigorous responses to foreign antigens. How this state of self/nonself discrimination is maintained is controversial. In the case of T cells, many self antigens are transported to the thymus via the bloodstream and induce tolerance (clonal deletion) of self-reactive thymocytes in situ.
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The immune system is constructed to tolerate self antigens but give vigorous responses to foreign antigens. How this state of self/nonself discrimination is maintained is controversial. In the case of T cells, many self antigens are transported to the thymus via the bloodstream and induce tolerance (clonal deletion) of self-reactive thymocytes in situ.
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Central tolerance: Clonal deletion or clonal arrest?
European Journal of Immunology, 1994AbstractStudies in various experimental animals have shown that developing T cells with specificity for self antigens can be prevented from maturation at an early stage of development. While several in vitro and in vivo experiments have shown that the mechanism of silencing autospecific T cells is the deletion of immature CD4+8+ thymocytes other ...
W, Swat, H, von Boehmer, P, Kisielow
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Medullary interplay for central tolerance
Blood, 2011To establish central tolerance in T cells, Aire, a nuclear protein expressed in medullary thymic epithelial cells, not only induces the ectopic expression of various self-antigens but also facilitates the indirect presentation of medullary thymic epithelial cell (mTEC)–derived self-antigens ...
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Tissue Tolerance: Central Nervous System
Radiology, 1968IN 1958 LAMPE (13) surveyed the experience to date with radiation tolerance of the central nervous system. He concluded that, as of that time, precise radiation tolerance limits of the central nervous system were not known for clinical radio-therapeutic practice. This still holds true today.
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Centrally acting vasopressin contributes to endotoxin tolerance
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1990Repeated daily intravenous injections of bacterial endotoxin induce a refractory state to their usual pyrogenic effects. The neuropeptide arginine vasopressin (AVP) has been implicated in natural fever suppression and may be involved in the process of pyrogenic tolerance to intravenous endotoxin.
M F, Wilkinson, N W, Kasting
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Knowing one's self: central tolerance revisited
Nature Immunology, 2003Tissue-specific antigens are expressed in the thymic medulla under the influence of the AIRE gene, suggesting that unresponsiveness to these peripheral antigens is a result of central tolerance. New data on T cell tolerance in AIRE−/− mice strongly support this hypothsis.
Jonathan Sprent, Charles D. Surh
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Antigen presentation for central tolerance induction
Nature Reviews ImmunologyThe extent of central T cell tolerance is determined by the diversity of self-antigens that developing thymocytes 'see' on thymic antigen-presenting cells (APCs). Here, focusing on insights from the past decade, we review the functional adaptations of medullary thymic epithelial cells, thymic dendritic cells and thymic B cells for the purpose of ...
Ludger, Klein, Elisabetta, Petrozziello
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