Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Les déficits publics en Europe:Causes, conséquences ou remèdes à la crise ? [PDF]
, 1950 La thèse selon laquelle la hausse des déficits et des dettes publics serait la cause essentielle du niveau élevé des taux d'intérêt réels n'a pas de sens dans la situation de demande insuffisante qu'a connue l'Europe depuis 1981. Cette hausse est apparue
Creel, Jérôme, Sterdyniak, Henri
core +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Investigaciones e investigadores de la UAM [PDF]
, 2017 Continuamos en este número de la revista con la sección: Investigaciones en la Universidad Autónoma de Madrid, con la que se pretende dar a conocer investigaciones relacionadas con diversas disciplinas científicas que se han desarrollado o se están ...
del Peso, Luis +4 more
core
The Small Hydropower in the Plans of promotion of renewable energies in Spain [PDF]
, 2016 La energía minihidráulica incluye las centrales con una potencia instalada de hasta 10 megavatios. Esta tecnología de producción energética se ha incluido en los Planes de Fomento de las Energías Renovables promovidos por los Gobiernos de España desde ...
Aparicio Guerrero, Ana Eulalia +2 more
core +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
[Etiology of low vision and blindness in seven reference centers in Colombia between the years 2012 to 2017Etiología da baixa visao e cegueira em sete centros de referencia na Colombia entre os anos de 2012 a 2017]. [PDF]
Rev Cuid, 2022 Suárez Escudero JC +11 more
europepmc +1 more source
Substance and chemical reaction as core concepts in chemistry. A conceptual, historical and pedagogical discussion [PDF]
, 2011 En este articulo se lleva a cabo una discusion conceptual, historica y didactica de dos conceptos centrales de la quimica: sustancia y reaccion quimica, en sus aspectos macroscopico y nanoscopico.
Garritz, Andoni +2 more
core +2 more sources
Atlixco ciudad con perfiles coloniales: la homogeneidad de la época Colonial [PDF]
, 2018 Atlixco es una ciudad culturalmente rica que ha trascendido desde su creación en el S.XVI hasta nuestros días, por el gran patrimonio tangible e intangible conservando sus inmuebles que muestran su desarrollo en el tiempo.
Martínez Bret, Pedro +1 more
core +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source