Results 81 to 90 of about 744,926 (184)

Dynamic Mechanical Loading Modulates Extracellular Vesicle Production and Cargo in Meniscus Fibrochondrocytes

Advanced Materials Interfaces, Volume 13, Issue 17, 8 September 2026.
Dynamic mechanical loading of outer meniscus fibrochondrocytes increases extracellular vesicle (EV) yield and alters EV composition. When applied to progenitor cells, these mechanically primed EVs modulate the expression of matrix‐related genes.
Catherine Cheung, Zizhao Li, Sung‐Han Jo, Se‐Hwan Lee, Il Keun Kwon, Jina Ko, Su Chin Heo   +6 more
wiley   +1 more source

Sleep Deprivation Induces Glial Dysfunction, Synaptic Loss, Metabolic Imbalance, and Cognitive Impairment in 12‐Month‐Old Mice: Protective Effects of D30

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Sleep deprivation induces neuroglial atrophy and dendritic spine loss, accompanied by metabolic disturbances involving 1‐methyladenosine, citric acid, L‐kynurenine, and berberine, indicating disrupted neuroenergetic and immunometabolic homeostasis. These alterations result in deficits in spatial recognition, fear conditioning, nesting, and Morris Water
Xueyan Liu, Huiling Lin, Jian Zhong, Xili Chen, Zonglin Wang, Meng Shi, Hang Shi, Hui Zhang, Ping Chen, Zu‐Cheng Ye   +9 more
wiley   +1 more source

Micellar chromatographic partition coefficients and their application in predicting skin permeability [PDF]

The major goal for physicochemical screening of pharmaceuticals is to predict human drug absorption, distribution, elimination, excretion and toxicity.
Shahzad, Yasser
core   +3 more sources

Submerged Fermentation of the Edible Mushroom Pleurotus ostreatus in a Batch Stirred Tank Bioreactor as a Promising Alternative for the Effective Production of Bioactive Metabolites

Molecules, 2012
The aim of this study was to investigate the potential of the submerged fermentation procedure in the production of bioactive metabolites of the common edible mushroom Pleurotus ostreatus.
Nikolas Fokialakis, Alexandros-Leandros Skaltsounis, Paul Christakopoulos, Evangelos Topakas, Lefki-Maria Papaspyridi, Nektarios Aligiannis   +5 more
doaj   +1 more source

Effects of Fomepizole on Acetaminophen Oxidative Metabolism: A Randomized, Crossover Study in Human Volunteers

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 795-805, September 2026.
Acetaminophen overdose can cause liver injury. Hepatotoxicity results from N‐acetyl‐p‐benzoquinone imine (NAPQI), generated via cytochrome P450‐2E1 (CYP2E1). Acetylcysteine is the mainstay of treatment, but efficacy may be reduced with delayed administration or large ingestions.
Sidharth Anand, Nicholas A. Buckley, Paul Stathakis, Laura James, Larry Parker, Mitchell R. McGill, Angela L Chiew   +6 more
wiley   +1 more source

Quality Prediction of a Tunisian Virgin Olive Oil Based on the Effect of Climate Change Using ANFIS Method

European Journal of Lipid Science and Technology, Volume 128, Issue 9, September 2026.
ANFIS accurately predicted climate‐driven variations in oleic acid, chlorophyll, and phenolic contents of Tunisian Zalmati virgin olive oil, demonstrating its potential as a reliable tool for olive oil quality assessment under changing climatic conditions.
Ines Zarrad, Rania Ben Hmida, Afif Masmoudi, Fakhreddine Dammak, Mohamed Bouaziz   +4 more
wiley   +1 more source

Selective Packaging of miR‐22 and miR‐29 Orthologues into Extracellular Vesicles of the Porcine Whipworm Trichuris Suis

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
ABSTRACT Helminths modulate host immunity, and in this respect, the porcine whipworm Trichuris suis has been explored clinically as an immunotherapy for inflammatory diseases. T. suis secretes a complex mixture of excretory/secretory products (ESP), including extracellular vesicles (EVs), nanosized membranous particles with bioactive cargoes of lipids,
Bradley Whitehead, Maibritt Mardahl, Eline P. Hansen, Bastian Fromm, Anne Borup, Anders Toftegaard Boysen, Jasmine C. L. Atay, Rikke Nørregaard, Allan Stensballe, Sidsel D. Andersen, Robin B. Gasser, Marco Brucale, Francesco Valle, Andrea Ridolfi, Eske Nøhr Glud, Merete Fredholm, Andrew R. Williams, Stig M. Thamsborg, Johan Palmfedt, Peter Nejsum   +19 more
wiley   +1 more source

Natural Product‐Derived Vesicles in Nanotherapeutics

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
Natural product‐derived vesicles (NPVs) are an emerging nature‐based nanotherapeutic that can deliver bioactive metabolites into the target site and induce beneficial mechanisms. A practical, chronological bench‐to‐bedside approach throughout the entire NPV development process is expected to resolve challenges encountered in NPV studies.
Kartiko Arif Purnomo, Tsong‐Long Hwang
wiley   +1 more source

Dual‐Drug‐Loaded Liposomes: Design Strategies, Mechanistic Insights, and Therapeutic Applications in Cancer

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
Dual‐drug‐loaded liposomes enable the simultaneous delivery of hydrophilic and hydrophobic therapeutics to tumors, enhancing anticancer efficacy and overcoming multidrug resistance. Through rational formulation design and surface functionalization, these systems improve tumor targeting, modulate efflux mechanisms and EMT, and achieve synergistic ...
Neelam Sinha, Rohan Chand Sahu, Rohit Patil, Dinesh Kumar, Ashish Kumar Agrawal   +4 more
wiley   +1 more source

Salix daphnoides: A Screening for Oligomeric and Polymeric Proanthocyanidins

Molecules, 2015
In the present study, a qualitative analysis of proanthocyanidins (PAs) from an aqueous-methanolic extract of Salix daphnoides VILL. bark is described. Procyanidin B1 (1), B2 (2), B3 (3), B4 (4), C1 (5), epicatechin-(4β→8)-epicatechin-(4β→8)-catechin (6)
Stefan Wiesneth, Frank Petereit, Guido Jürgenliemk   +2 more
doaj   +1 more source