Results 261 to 270 of about 26,352 (303)
CENP-A Is Dispensable for Mitotic Centromere Function after Initial Centromere/Kinetochore Assembly.
Cell Reports, 2016 Sebastian Hoffmann +8 more
semanticscholar +1 more source
Clinicopathological Features of Mixed Connective Tissue Disease‐Related Myositis: A Case Series
Muscle &Nerve, Volume 71, Issue 4, Page 583-592, April 2025.ABSTRACT Introduction Mixed connective tissue disease (MCTD) patients often have myositis, however, myopathological and clinical data for MCTD are limited. Recent reports have shown that the pathology of MCTD myositis resembles that of immune‐mediated necrotizing myopathy (IMNM), whereas earlier reports described perifascicular atrophy or inflammatory ...
Naohiro Sakamoto +4 more
wiley +1 more source
A single G-to-C change causes human centromere TGGAA repeats to fold back into hairpins.
, 1996 Lianjie Zhu +2 more
openalex +1 more source
Protein Science, Volume 34, Issue 4, April 2025.Abstract During mitosis, unattached kinetochores trigger the spindle assembly checkpoint by promoting the assembly of the mitotic checkpoint complex, a heterotetramer comprising Mad2, Cdc20, BubR1, and Bub3. Critical to this process is the kinetochore‐mediated catalysis of an intrinsically slow conformational conversion of Mad2 from an open (O‐Mad2 ...
Conny W. H. Yu +6 more
wiley +1 more source
Molecular Ecology Resources, Volume 25, Issue 3, April 2025.ABSTRACT Large and highly repetitive genomes are common. However, research interests usually lie within the non‐repetitive parts of the genome, as they are more likely functional, and can be used to answer questions related to adaptation, selection and evolutionary history.
Robert Kesälahti +9 more
wiley +1 more source
Thoracic Cancer, Volume 16, Issue 7, April 2025.IFI30 is highly expressed in ESCC. Knockdown of IFI30 may upregulate HRAS and promote ROS generation, thereby activating the JNK signaling pathway and increasing p16/p21 expression, ultimately inducing apoptosis and senescence in ESCC cells. This study underscores the pivotal role of IFI30 in regulating apoptosis and senescence in ESCC cells and ...
Wenyao Xie +8 more
wiley +1 more source
Aging Cell, Volume 24, Issue 4, April 2025.We sought to identify the cerebrospinal fluid protein (CSF) changes that are associated with the APOE4 genetic variant to better understand the vulnerability of APOE4 carriers to progress to Alzheimer's disease (AD) with age. To do this, we used machine learning and enrichment analyses to analyze 6082 proteins in the CSF of cognitively normal, mild ...
Artur Shvetcov +8 more
wiley +1 more source
Age‐associated accumulation of RAB9 disrupts oocyte meiosis
Aging Cell, Volume 24, Issue 4, April 2025.This study showed that RAB9 protein accumulates in old human and mouse oocytes. RAB9 accumulation disrupted spindle formation, chromosome alignment and actin cap formation, increased ROS levels, decreased mitochondrial membrane potential, ATP content, mtDNA/nDNA ratio and activated the PINK1‐PARKIN pathway. Importantly, knockdown of RAB9 in old oocytes
Min Gao +10 more
wiley +1 more source
Molecular architecture of classical cytological landmarks: Centromeres and telomeres
, 1994 J. Meyne
openalex +1 more source
New Phytologist, Volume 246, Issue 2, Page 581-597, April 2025.Summary Polyploidy plays a key role in genome evolution and crop improvement. The formation of bivalents rather than multivalents during meiosis of polyploids is essential to ensure meiotic stability and optimal fertility of the species. However, the mechanisms preventing multivalent recombination in polyploids remain obscure.
Yashi Zhang +9 more
wiley +1 more source