Results 241 to 250 of about 92,899 (342)

The deSUMOylase SPF2 and the cohesin regulators SGO2 and CTF18 suppress crossovers near centromeres. [PDF]

Nat Plants
Salinas Gamboa R, Fernandes JB, Lian Q, Singh DK, Durand S, Sahu D, Capilla-Perez L, Lopez H, Kalde A, Mercier R.   +9 more
europepmc   +1 more source

LncRNA A1BGAS1 Serves as a Tumor Suppressor in Non‐Small Cell Lung Cancer by Modulating the Expression of miR‐3942‐5P

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
This study verified the potential of A1BG‐AS1 to serve as a molecular biomarker for NSCLC prognosis. Mechanistically, A1BG‐AS1 exerts inhibitory effects on NSCLC cell proliferation, migration, and invasion and exerts a promoting effect on apoptosis via direct targeting and downregulation of miR‐3942‐5p.
Jiahui Du, Zhenhua Li, Chunqiang Wang, Xuexi Zhang   +3 more
wiley   +1 more source

Routine MDM2 FISH Testing and Preoperative Biopsy Reduces Recurrence Rate of Atypical Lipomatous Tumours

Journal of Surgical Oncology, Volume 134, Issue 6, Page 814-821, November 2026.
ABSTRACT Background Although MDM2 FISH test has been increasingly used to differentiate ALT and benign lipomatous tumours, its impact on clinical outcome remains underexplored. This study investigated whether routine MDM2 FISH testing on preoperative biopsy is associated with a reduction in the recurrence risk of ALT.
Samuel O. H. Ching, Anderson S. M. Leung, Raymond C. H. Yau, Albert Y. L. Lam, Tony W. H. Shek, Maximus C. F. Yeung   +5 more
wiley   +1 more source

Cryo-EM structures of CENP-A nucleosomes isolated from human cells. [PDF]

Commun Biol
Tanida E, Hatazawa S, Oishi T, Kobayashi Y, Ogasawara M, Jaskiewicz MA, Harada A, Fujii T, Ohkawa Y, Takizawa Y, Kurumizaka H.   +10 more
europepmc   +1 more source

LPCAT3 as a Potential Drug Target for Ultraviolet Radiation–Induced Cataract: Insights From Multiomics Analysis

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 11, November 2026.
ABSTRACT Ultraviolet B (UVB) radiation is a major risk factor for cataract development, but the molecular mechanisms underlying this process, particularly the involvement of regulated cell death pathways such as ferroptosis, remain unclear. Transcriptomic, proteomic, and metabolomic analyses were performed on lens tissues from UVB‐induced cataract rat ...
Fei Xu, Xiao‐Bo Wan, Yong‐Shun Liang, Tian Lan, Hao Liang   +4 more
wiley   +1 more source

Analysis of a hypomorphic mei-P26 mutation reveals coordination between developmental programming of germ cells and meiotic chromosome dynamics. [PDF]

Genetics
Terry J, Solomon A, Powell AM, Terry P, Bautista O, Landes M, Berent E, Ables ET, Crown N.   +8 more
europepmc   +1 more source

Histone Deacetylase 3‐Progesterone Receptor Cooperation Regulates Progesterone Responsiveness in the Uterus

MedComm, Volume 7, Issue 11, November 2026.
HDAC3 and PGR exhibit coordinated expression and chromatin occupancy in the receptive endometrium. Loss of HDAC3‐PGR cooperation in endometriosis disrupts progesterone‐responsive gene regulation and impairs uterine receptivity. ABSTRACT Endometriosis affects a substantial proportion of women of reproductive age, with 30%–50% affected by infertility.
Sohyeon Yun, Rong Li, Soo Lim Kim, Loan Thi Kim Nguyen, Shamsun Nahar, Keun Cheon Kim, DaHye Kang, Eunhee M. Jeong, Lisa Brennaman, Mistie P. Mills, Steven L. Young, Bruce A. Lessey, Tae Hoon Kim, Jung‐Yoon Yoo, Jae‐Wook Jeong   +14 more
wiley   +1 more source

Neocentromeres fail to maintain DNA methylation boundaries, driving CENP-A drift, instability, and chromosome missegregation. [PDF]

Cell Rep
Mahlke MA, Enriquez A, Lumerman L, Nath P, Chittenden C, Hoyt S, Koeppel J, Xu Y, Raphael R, Zaffina K, Hook PW, Timp W, Miga KH, Campbell PJ, O'Neill RJ, Altemose N, Nechemia-Arbely Y.   +16 more
europepmc   +1 more source

Comprehensive genomic profiling of mucosal melanoma reveals novel fusion transcripts and dysregulation of cell‐cycle, MAPK, and PI3K pathways

The Journal of Pathology, Volume 270, Issue 3, Page 380-395, November 2026.
Abstract Mucosal melanomas (MMs) are rare, aggressive cancers with poor outcomes and limited response to standard therapies. A significant knowledge gap exists regarding their genomic landscape and corresponding druggable targets. This study explores this issue through a multi‐omic analysis, including whole exome‐, RNA‐, and targeted sequencing, of ...
Matilde Monti, Martina Brigida Romanello, Luca Agnelli, Matteo Orlandi, Luca Bertoli, Sara Picinoli, Irene Pezzali, Giulio Eugenio Mandelli, Daniela Medicina, Giovanni Ribaudo, Adele Busico, Elena Conca, Vilma Pellegrini, Piera Balzarini, Daniele Gallucci, Anna Di Matteo, Davide Lombardi, Claudia Ghigna, Giancarlo Pruneri, Alessandra Gianoncelli, Marzia Rossato, William Vermi   +21 more
wiley   +1 more source

Complete chromosome 21 centromere sequencing of families with Down syndrome. [PDF]

Am J Hum Genet
Mastrorosa FK, Daponte A, de Gennaro L, Chuang SC, Lin J, Sui Y, Porubsky D, Oshima KK, Wertz J, Rozanski AN, Harvey WT, Wang Y, Leung TY, Chan DD, He W, Knuth J, Garcia GH, Ayllon M, Munson KM, Hoekzema K, Lansdorp PM, Catacchio CR, Ventura M, Sherman SL, Allen EG, Rosser TC, Logsdon GA, Eichler EE.   +27 more
europepmc   +1 more source