Results 221 to 230 of about 92,899 (342)

MET Expression in Upper Gastrointestinal Adenocarcinoma: Prevalence, Prognostic Impact, and Implications for Anti‐MET Antibody‐Drug Conjugate Therapy

International Journal of Cancer, Volume 159, Issue 10, Page 2606-2618, 15 November 2026.
ABSTRACT MET is an actionable receptor tyrosine kinase, and MET‐directed antibody–drug conjugates (ADCs) have recently entered clinical practice with FDA approval in non‐small cell lung cancer and are now being evaluated across gastrointestinal malignancies, with patient selection based on MET immunohistochemistry (IHC) 3+ membranous staining at ...
Tillmann Bedau, Thomas Zander, Hans Anton Schlößer, Hakan Alakus, Onur Mustafov, Reinhard Büttner, Christiane Bruns, Alexander Quaas   +7 more
wiley   +1 more source

The peculiar properties of pericentromeric regions of genomes and their influence on sex chromosome evolution. [PDF]

PLoS Genet
Charlesworth D.
europepmc   +1 more source

Coiled Coils as a Programmable Platform for Computational Biosensor Design

ChemBioChem, Volume 27, Issue 21, 12 November 2026.
Coiled coils provide compact, programmable scaffolds for converting molecular recognition and conformational change into biosensor outputs. Their sequence–structure principles are supported by computational design strategies for tuning affinity, orthogonality, switching, and robustness, enabling biosensors that respond to diverse environmental and ...
Paul Kluge, Faezeh Shabani, Sibylle Gemming, Georg Künze   +3 more
wiley   +1 more source

Two near-complete assemblies reveal R-subgenome structural and centromeric divergence associated with reproductive isolation in hexaploid triticale. [PDF]

Imeta
Liu Y, He W, Wang C, Yi C, Guo T, Zhu C, Liu Q, Han F.   +7 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, Volume 20, Issue 11, Page 2820-2838, November 2026.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

An interdependent Cbf1-CCAN interaction stabilizes the budding yeast kinetochore. [PDF]

Proc Natl Acad Sci U S A
Hedouin S, Hu C, Biggins S.
europepmc   +1 more source

PRAME predicting outcome in uveal melanoma

The Journal of Pathology: Clinical Research, Volume 12, Issue 6, November 2026.
Abstract Uveal melanoma (UM) is the most common primary intra‐ocular malignancy in adults and carries a high risk of metastatic disease, affecting approximately 50% of patients despite advances in local tumour control. PRAME (PReferentially expressed Antigen in MElanoma) has emerged as a marker for metastatic risk; however, evidence is largely derived ...
Sally Owens, Naomi Walsh, Noel Horgan, Patrick Murtagh, Katie Hanratty, Grainne Finegan, Laura Ivers, John Crown, Susan Kennedy   +8 more
wiley   +1 more source

Phased T2T horse and donkey assemblies from a mule reveal peculiar equid centromere evolution. [PDF]

Cell Genom
Li K, Cappelletti E, Dessaix C, Ciosek J, Robyn E, Johnson L, AbouEl Ela NH, Arias X, Adelson DL, Raudsepp T, Piras FM, Smith ML, Hudson E, Pickett BD, Koren S, Walenz BP, Brooks SY, Sison C, Crawford J, Bouffard G, Phillippy AM, Miller D, Antczak DF, Cullen J, Stroupe S, Davis BW, McCue M, Durward-Akhurst SA, Petersen JL, Giulotto E, Kalbfleisch T.   +30 more
europepmc   +1 more source

Characteristics and Outcomes of Male Participants in a Multicenter Longitudinal Australian Study Cohort

Arthritis Care &Research, Volume 78, Issue 11, Page 1701-1710, November 2026.
Objective The aim of this study was to determine the differences in demographic, serologic, and clinical characteristics between male and female patients with systemic sclerosis (SSc) in an Australian cohort. Methods This was a retrospective observational study using data from the Australian Scleroderma Cohort Study.
Emily Lin, Dylan Hansen, Laura Ross, Gene‐Siew Ngian, Susanna Proudman, Gabor Major, Maryam Tabesh, Mandana Nikpour, Jennifer Walker, Lauren Host, Nava Ferdowsi, Alannah Quinlivan, Wendy Stevens, Joanne Sahhar, Diane Apostolopoulos   +14 more
wiley   +1 more source

Natural variation modifies centromere-proximal meiotic crossover frequency and segregation distortion in Arabidopsis thaliana. [PDF]

Genetics
Gorringe N, Topp S, Burns R, Yamaguchi S, Rabanal FA, Fernandes JB, Weigel D, Kakutani T, Naish M, Henderson IR.   +9 more
europepmc   +1 more source