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Heterochromatin boundaries maintain centromere position, size and number

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Carty BL   +11 more
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Emerging roles of centromeric RNAs in centromere formation and function

Genes & Genomics, 2021
Centromeres are specialized chromosomal domains involved in kinetochore formation and faithful chromosome segregation. Despite a high level of functional conservation, centromeres are not identified by DNA sequences, but by epigenetic means. Universally, centromeres are typically formed on highly repetitive DNA, which were previously considered to be ...
Yang Liu   +7 more
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Centromeric retrotransposons and centromere function

Current Opinion in Genetics & Development, 2018
The centromeric DNA of most multicellular eukaryotes consists of tandem repeats (TR) that bind centromere-specific proteins and act as a substrate for the efficient repair of frequent double-stranded DNA breaks. Some retrotransposons target active centromeres during integration with such specificity that they can be used to deduce current and historic ...
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Centromerization

Trends in Cell Biology, 2000
Centromere formation is a complex process that involves the packaging of DNA into a centromere-unique chromatin, chemical modification and the seeding of kinetochore and associated proteins. The early steps in this process, in which a chromosomal region is marked for centromerization (that is, to become resolutely committed to centromere formation ...
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Sister chromatid exchange in the centromere and centromeric area

Human Genetics, 1983
Central and peripheral sister chromatid exchanges (SCE) were evaluated separately in human phytohemagglutinin (PHA)-stimulated lymphocytes after culture for 72 h in 5-bromodeoxyuridine (BrdU) containing medium. At the same time, the length of chromosome No.
Reinhard Becher, Avery A. Sandberg
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Silence of the centromeres – not

Trends in Biotechnology, 2004
Centromeres are a conundrum; although many proteins associated with centomeres are conserved from yeast to humans, the underlying DNA sequence is not. A proposed solution to this problem is that an epigenetic, largely heterochromatic, state be imposed by these proteins.
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Centromere spreading and centromeric aberrations in ovarian tumors

Cancer Genetics and Cytogenetics, 1995
Centromere spreading (CS) of chromosomes and high occurrence of aberrations at centromeric region were observed in two papillary serous cystadenocarcinomas and one borderline papillary serous cystadenoma of the ovary. In the borderline tumor, CS of chromosome 12, trisomy of which had been reported as the sole abnomaly in benign ovarian tumors, was seen
Mei S. Ma   +3 more
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Plant centromeres

Current Opinion in Plant Biology, 2017
Plant centromeres, which are determined epigenetically by centromeric histone 3 (CENH3) have revealed surprising structural diversity, ranging from the canonical monocentric seen in vertebrates, to polycentric, and holocentric. Normally stable, centromeres can change position over evolutionary times or upon genomic stress, such as when chromosomes are ...
Luca, Comai   +2 more
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