Results 291 to 300 of about 87,751 (339)

The molecular basis for centromere identity and function

open access: yesNature Reviews Molecular Cell Biology, 2015
The centromere is the region of the chromosome that directs its segregation in mitosis and meiosis. Although the functional importance of the centromere has been appreciated for more than 130 years, elucidating the molecular features and properties that ...
Kara L Mckinley   +2 more
exaly   +2 more sources

Plant centromeres

Current Opinion in Plant Biology, 2017
Plant centromeres, which are determined epigenetically by centromeric histone 3 (CENH3) have revealed surprising structural diversity, ranging from the canonical monocentric seen in vertebrates, to polycentric, and holocentric. Normally stable, centromeres can change position over evolutionary times or upon genomic stress, such as when chromosomes are ...
Luca, Comai   +2 more
openaire   +2 more sources

Epigenetic Control of Centromere Behavior

open access: yesAnnual Review of Genetics, 2007
The centromere is the DNA region that ensures genetic stability and is therefore of vital importance. Paradoxically, centromere proteins and centromeric structural domains are conserved despite that fact that centromere DNA sequences are highly variable ...
Karl Ekwall
exaly   +2 more sources

Plant Centromeres

2008
Plant centromeres are generally composed of tandem arrays of simple repeats that are typical of a particular species, but that evolve rapidly. Centromere specific retroelements are also present. These arrays associate with a centromere specific variant of histone H3 that anchors the site of the kinetochore.
J C, Lamb, W, Yu, F, Han, J A, Birchler
openaire   +2 more sources

Centromerization

Trends in Cell Biology, 2000
Centromere formation is a complex process that involves the packaging of DNA into a centromere-unique chromatin, chemical modification and the seeding of kinetochore and associated proteins. The early steps in this process, in which a chromosomal region is marked for centromerization (that is, to become resolutely committed to centromere formation ...
openaire   +2 more sources

Inbreeding drives maize centromere evolution

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2016
Zidian Xie   +2 more
exaly   +2 more sources

CENP-A Is Dispensable for Mitotic Centromere Function after Initial Centromere/Kinetochore Assembly

open access: yesCell Reports, 2016
Human centromeres are defined by chromatin containing the histone H3 variant CENP-A assembled onto repetitive alphoid DNA sequences. By inducing rapid, complete degradation of endogenous CENP-A, we now demonstrate that once the first steps of centromere ...
Marie Dumont, Viviana Barra, Peter Ly
exaly   +2 more sources

Silence of the centromeres – not

Trends in Biotechnology, 2004
Centromeres are a conundrum; although many proteins associated with centomeres are conserved from yeast to humans, the underlying DNA sequence is not. A proposed solution to this problem is that an epigenetic, largely heterochromatic, state be imposed by these proteins.
openaire   +2 more sources

Centromere spreading and centromeric aberrations in ovarian tumors

Cancer Genetics and Cytogenetics, 1995
Centromere spreading (CS) of chromosomes and high occurrence of aberrations at centromeric region were observed in two papillary serous cystadenocarcinomas and one borderline papillary serous cystadenoma of the ovary. In the borderline tumor, CS of chromosome 12, trisomy of which had been reported as the sole abnomaly in benign ovarian tumors, was seen
D, Zhu, M S, Ma, R Z, Zhao, M Y, Li
openaire   +2 more sources

The Centromere Paradox: Stable Inheritance with Rapidly Evolving DNA

Science, 2001
Every eukaryotic chromosome has a centromere, the locus responsible for poleward movement at mitosis and meiosis. Although conventional loci are specified by their DNA sequences, current evidence favors a chromatin-based inheritance mechanism for ...
S. Henikoff, K. Ahmad, Harmit S. Malik
semanticscholar   +1 more source

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