Results 201 to 210 of about 74,831 (235)

DNAJ-PKAc fusion heightens PLK1 inhibitor sensitivity in fibrolamellar carcinoma. [PDF]

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Centrosome instability: when good centrosomes go bad

Cellular and Molecular Life Sciences, 2021
The centrosome is a tiny cytoplasmic organelle that organizes and constructs massive molecular machines to coordinate diverse cellular processes. Due to its many roles during both interphase and mitosis, maintaining centrosome homeostasis is essential to normal health and development. Centrosome instability, divergence from normal centrosome number and
John M. Ryniawec, Gregory C. Rogers
openaire   +2 more sources

Centrosomal and non‐centrosomal microtubules

Biology of the Cell, 1999
While microtubule (MT) arrays in cells are often focused at the centrosome, a variety of cell types contain a substantial number of non‐centrosomal MTs. Epithelial cells, neurons, and muscle cells all contain arrays of non‐centrosomal MTs that are critical for these cells' specialized functions. There are several routes by which non‐centrosomal MTs can
T J, Keating, G G, Borisy
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Centrosome maturation

1999
In the past, centrosome maturation has been described as the change in microtubule nucleation potential that occurs as cells pass through specific phases of the cell cycle. It is suggested that the idea of centrosome maturation be expanded to include gain of functions that are not necessarily related to microtubule nucleation.
R E, Palazzo   +4 more
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Centrosomes and Centrosome Equivalents in Other Systems

2022
Stem cells are important to sustain tissue growth during development, to repair damaged tissue after injury, and to maintain homeostasis during adulthood. Precisely programmed stem cell renewal and differentiation is critical, as failure in balance can lead to tumorigenesis as a result of over-proliferation or to degeneration as a result of decline in ...
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Centrosomal TACCtics

BioEssays, 2002
AbstractAlthough the centrosome was first described over 100 years ago, we still know relatively little of the molecular mechanisms responsible for its functions. Recently, members of a novel family of centrosomal proteins have been identified in a wide variety of organisms.
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