Results 211 to 220 of about 74,831 (235)
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Centrosome Clustering & Chemotherapy
Mini-Reviews in Medicinal Chemistry, 2023Abstract: Centrosome abnormalities are the hallmark of cancer. How it affects tumorigenesis is still a mystery. However, the presence of more than two centrosomes at the onset of mitosis often leads to chromosomal instability and subsequent tumorigenesis.
Rahman Shah Zaib Saleem +5 more
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Biology of the Cell, 1999
The centrosome functions as the major microtubule organizing center (MTOC) of the cell and as such it determines the number, polarity, and organization of interphase and mitotic microtubules. Cytoplasmic organization, cell polarity and the equal partition of chromosomes into daughter cells at the time of cell division are all dependent on the normal ...
J L, Salisbury +3 more
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The centrosome functions as the major microtubule organizing center (MTOC) of the cell and as such it determines the number, polarity, and organization of interphase and mitotic microtubules. Cytoplasmic organization, cell polarity and the equal partition of chromosomes into daughter cells at the time of cell division are all dependent on the normal ...
J L, Salisbury +3 more
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Centrosome biogenesis and function: centrosomics brings new understanding
Nature Reviews Molecular Cell Biology, 2007Centrosomes, which were first described in the late 19th century, are found in most animal cells and undergo duplication once every cell cycle so that their number remains stable, like the genetic material of a cell. However, their function and regulation have remained elusive and controversial. Only recently has some understanding of these fundamental
Mónica, Bettencourt-Dias +1 more
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2022
Centrosome functions are vitally important for all aspects of reproduction with essential functions during meiosis, fertilization, cell division, centrosome remodeling during cellular polarization for tissue formation, and all stages of subsequent embryo development.
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Centrosome functions are vitally important for all aspects of reproduction with essential functions during meiosis, fertilization, cell division, centrosome remodeling during cellular polarization for tissue formation, and all stages of subsequent embryo development.
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Centrosome-microtubule nucleation
Journal of Cell Science, 1997ABSTRACT In many cell types the formation of microtubules from tubulin subunits is initiated at defined nucleation sites at the centrosome. Thesse sites contain the conserved γ-tubulin which is in association with additional not very well characterised proteins, identified as components of a γ-tubulin ring complex from Xenopus egg ...
Pereira, G, Schiebel, E
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Aurora A, centrosome structure, and the centrosome cycle
Environmental and Molecular Mutagenesis, 2009AbstractThe centrosome, also known as the microtubule organizing center of the cell, is a membrane‐less organelle composed of a pair of barrel‐shaped centrioles surrounded by electron‐dense pericentriolar material. The centrosome progresses through the centrosome cycle in step with the cell cycle such that centrosomes are duplicated in time to serve as
Kara B, Lukasiewicz, Wilma L, Lingle
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Centrosome competition: A possibility?
Experimental Cell Research, 1990A recent theory on the evolution of sexuality, has hypothesized heritable variation in the functional properties of centrosomes, leading to competition for the organization of the mitotic spindle when different centrosomes enter a common cytoplasm.
MARIN G., ARGENTON, FRANCESCO
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2006
Centrosomes are dynamic organelles involved in many aspects of cell function and growth. Centrosomes act as microtubule organizing centers, and provide a site for concerted regulation of cell cycle progression. While there is diversity in microtubule organizing center structure among eukaryotes, many centrosome components, such as centrin, are ...
Christopher P, Mattison, Mark, Winey
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Centrosomes are dynamic organelles involved in many aspects of cell function and growth. Centrosomes act as microtubule organizing centers, and provide a site for concerted regulation of cell cycle progression. While there is diversity in microtubule organizing center structure among eukaryotes, many centrosome components, such as centrin, are ...
Christopher P, Mattison, Mark, Winey
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Centrosomes and parthenogenesis
2001Publisher Summary This chapter describes the parthenogenetic assay and reviews the results concerning the capacity of centrosomes isolated from different cell types in different species to induce frog egg cleavage. The chapter discusses the potential of current in vitro systems to identify important molecular events of the pathway and also ...
F, Tournier, M, Bornens
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Rethinking centrosome function
Trends in Cell Biology, 2001A debate has raged for over 100 years concerning the role of centrosomes in cell division. It is now well known that bipolar spindles can self-assemble without centrosomes. On the other hand, recent genetic experiments in Chlamydomonas 1xExtragenic bypass suppressors of mutations in the essential gene BLD2 promote assembly of basal bodies with abnormal
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