Results 71 to 80 of about 110,179 (326)
The problem with cephalosporins [PDF]
Journal of Antimicrobial Chemotherapy, 2001 The cephalosporin antibiotics have become a major part of the antibiotic formulary for hospitals in affluent countries. They are prescribed for a wide variety of infections every day. Their undoubted popularity relies upon lesser allergenic and toxicity risks as well as a broad spectrum of activity.
openaire +3 more sources
BMC Infectious Diseases, 2013 BackgroundThe spread of Neisseria gonorrhoeae strains with mosaic penA alleles and reduced susceptibility to extended-spectrum cephalosporins is a major public health problem.
Severin O Gose +5 more
semanticscholar +1 more source
Impact of Model‐Informed Drug Development on Drug Development Cycle Times and Clinical Trial Cost
Clinical Pharmacology &Therapeutics, EarlyView.Model‐informed drug development (MIDD) integrates data to quantify benefit/risk informing objective drug discovery and development decisions. An additional critical benefit of MIDD is postulated to be improvement in trial and program efficiencies. While the application of MIDD has grown, there have been no clear examples across programs to demonstrate ...
Vaishali Sahasrabudhe +4 more
wiley +1 more source
New oil modified acrylic polymer for pH sensitive drug release: Experimental results and statistical analysis [PDF]
arXiv, 2014 We report results of an experimental study, complemented by detailed statistical analysis of the experimental data, on the development of a more effective control method of drug delivery using a pH sensitive acrylic polymer. New copolymers based on acrylic acid and fatty acid are constructed from dodecyl castor oil and a tercopolymer based on methyl ...
arxiv
Journal of Veterinary Internal Medicine, Volume 37, Issue 1, Page 223-229, January/February 2023., 2023 Abstract Background Bacterial meningitis (BM) and meningoencephalitis (BMEM) are associated with high case fatality rates and neurologic sequelae in people, but limited data exists on outcome in dogs. Hypothesis/Objectives To report the clinicopathologic features, treatment and outcome of BM/BMEM in dogs, with a focus on clinical presentation, relapse ...
Faye Rawson +5 more
wiley +1 more source
Исследования и практика в медицине, 2015 :Acute pyelonephritis is one of the common diseases both in outpatient and in the hospital practice. The leading causative agent of this disease is E. coli.
A. D. Kaprin, A. A. Kostin, S. V. Popov
doaj +1 more source
Optimizing defence, counter-defence and counter-counter defence in parasitic and trophic interactions -- A modelling study [PDF]
arXiv, 2019 In host-pathogen interactions, often the host (attacked organism) defends itself by some toxic compound and the parasite, in turn, responds by producing an enzyme that inactivates that compound. In some cases, the host can respond by producing an inhibitor of that enzyme, which can be considered as a counter-counter defence.
arxiv
Early experience with the gasless vNOTES technique for adnexal surgery
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Introduction This study evaluates the feasibility, safety, and outcomes of gasless vNOTES (vaginal Natural Orifice Transluminal Endoscopic Surgery) for benign adnexal surgeries. Materials and Methods This was an observational, retrospective study performed in two centers with over 3 years of experience in vNOTES: the University Hospital Center
Pierre‐Alexis Gauci +5 more
wiley +1 more source
Sepsis and survival in critically ill calves: Risk factors and antimicrobial use
Journal of Veterinary Internal Medicine, Volume 37, Issue 1, Page 374-389, January/February 2023., 2023 Abstract Background Sepsis is a life‐threatening disease for which critically important antimicrobials (CIA) frequently are used. Diagnostic and therapeutic guidelines for sepsis and critically ill calves are largely lacking. Objectives Identify factors associated with mortality in critically ill calves and describe bacteria obtained from blood ...
Mathilde L. Pas +4 more
wiley +1 more source
Antimicrobial Agents and Chemotherapy, 2012 The structure of Mycobacterium tuberculosis peptidoglycan is atypical since it contains a majority of 3→3 cross-links synthesized by l,d-transpeptidases that replace 4→3 cross-links formed by the d,d-transpeptidase activity of classical penicillin ...
V. Dubée +8 more
semanticscholar +1 more source