Results 231 to 240 of about 31,716 (293)

BIOCARD framework: integrating fecal bile acids, lipids, and metabolites to assess response to a cardiovascular health intervention. [PDF]

Gut Microbes
Zhang H, Chen L, Xu R, Jung H, Gao S, Khalsa AS, Bailey MT, Kelleher KJ, Loman BR, Spees CK, Zhu J.   +10 more
europepmc   +1 more source

Pharmacological Inhibition of Small Extracellular Vesicle Secretion by ALK5i SD‐208 via Lysosomal Rerouting of CD63+ Compartments

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
ABSTRACT Pharmacological tools to selectively modulate extracellular vesicle (EV) secretion are scarce. Here, we identify the ALK5 (TGF‐β receptor I) inhibitor SD‐208 as a potent suppressor of small EV (sEV) secretion that acts independently of its canonical anti‐fibrotic activity.
Rahul Sanwlani, Georgina H. Thompson, Kyle Bramich, Ching‐Seng Ang, Millie L. Trowbridge, Chris E. Duringer, Vlad Stolojan, Sean M. Davidson, Konstantinos Savvatis, John H. McVey, Suresh Mathivanan, Aled Clayton, Patrizia Camelliti   +12 more
wiley   +1 more source

Detergents without a drain: the evolutionary logic (and liability) of sphingolipids. [PDF]

J Lipid Res
Summers SA.
europepmc   +1 more source

Natural Product‐Derived Vesicles in Nanotherapeutics

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
Natural product‐derived vesicles (NPVs) are an emerging nature‐based nanotherapeutic that can deliver bioactive metabolites into the target site and induce beneficial mechanisms. A practical, chronological bench‐to‐bedside approach throughout the entire NPV development process is expected to resolve challenges encountered in NPV studies.
Kartiko Arif Purnomo, Tsong‐Long Hwang
wiley   +1 more source

Linoleic acid concentration at the air-liquid interface is key for optimal incorporation into skin model lipidome. [PDF]

Front Physiol
Tremblay A, Larouche A, Simard M, Dumais É, Julien P, Flamand N, Pouliot R.   +6 more
europepmc   +1 more source

GW4869 Depletes Macrophages and Increases Number of Extracellular Vesicles in Murine Peritoneal Cavity Fluid

Journal of Extracellular Biology, Volume 5, Issue 9, September 2026.
ABSTRACT Pharmacological strategies to modulate extracellular vesicle (EV) release in vivo are gaining traction, yet their broader effects on local immune microenvironments remain unclear. In this study, we assessed how repeated intraperitoneal (i.p.) dosing of the neutral sphingomyelinase inhibitor GW4869 reshapes the peritoneal cavity.
Johann Mar Gudbergsson, Pedro Henrique Gobira, Rodrigo Grassi‐Oliveira, Anders Etzerodt   +3 more
wiley   +1 more source

Chemogenetic Activation of G₁₂ Signaling Thickens the Epidermis With Enhanced Barrier Function. [PDF]

FASEB Bioadv
Kamakura N, Hirai N, Arai K, Du Y, Kogame T, Ohno Y, Kihara A, Kabashima K, Inoue A.   +8 more
europepmc   +1 more source

Lipidomics reveals the pro-viral roles of ceramides during fish nodavirus infection. [PDF]

J Virol
Zhang Y, Liu L, Lin L, Zhao Y, Xi K, Guo X, Qin Q, Huang X, Huang Y.   +8 more
europepmc   +1 more source

Xanthohumol and its non-estrogenic derivatives link to the gut-liver-brain axis to improve cognition in mice with diet-induced obesity. [PDF]

Front Physiol
Alexiev A, Stagaman K, Kasschau K, Zhang Y, Raber J, Gombart AF, Maier CS, Stevens JF, Sharpton TJ.   +8 more
europepmc   +1 more source

A Reproducible Ceramide Phenotype of Sepsis Across Aetiologies - A Monocenter Cohort Study. [PDF]

J Inflamm Res
Pavel V, Mester P, Höring M, Krautbauer S, Liebisch G, Schmid S, Müller M, Buechler C.   +7 more
europepmc   +1 more source