Results 221 to 230 of about 31,716 (293)

Beyond Traditional Screening: The Future of Heart Failure Detection With Biomarkers and AI

iNew Medicine, Volume 2, Issue 3, September 2026.
Advancing HF Screening: Integrating Technology and Risk Factors Across Eras. This diagram provides a comprehensive review of the historical developments and projected trends of heart failure (HF) screening methodologies, with the prevalent risk factors for HF depicted at the base.
Xiaofeng Fang, Yinbo Xu, Yiting Zhao, Liuyi Li, Zhengyi Cheng, Zhongqi Zhang, Yuhang Luo, Qiaoling Liu, Chen Gong, Shichun Shen   +9 more
wiley   +1 more source

Hepatic lipid quantity and quality in type 2 diabetes mellitus. [PDF]

Front Pharmacol
Shimizu K, Shindou H, Tomita K, Mizuguchi H.   +3 more
europepmc   +1 more source

Engineering Extracellular Vesicles: Strategies for Functional Modification and Clinical Translation

iNew Medicine, Volume 2, Issue 3, September 2026.
The engineering modification strategies of extracellular vesicles (EVs). This figure presents the four core technical systems for the engineering modification of EVs, including direct modification strategies (physical and chemical methods), biological engineering methods, and hybrid and bionic strategies.
Zhouming Cheng, Wenhui Zhao, Min Wang, Xianwen Wang   +3 more
wiley   +1 more source

FASN-mediated <i>de novo</i> lipogenesis promotes ceramide accumulation and myocardial damage in arrhythmogenic cardiomyopathy. [PDF]

iScience
Liu Z, Cui H, Yang T, Shu S, Chen Z, Han J, Su M, Huang J, Chen X, Song J, Hu S.   +10 more
europepmc   +1 more source

Iron‐Sulfur Cluster Targeting: A Novel Perspective for Treating Alcohol‐Related Lipid Metabolic Diseases

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Alcohol metabolism induces structural instability of iron‐sulfur clusters through ROS‐mediated oxidative damage and direct covalent modification of acetaldehyde. The iron‐sulfur cluster deficiency drives metabolic reprogramming by inactivating aconitase, accumulating succinate, and impairing tRNA thiolation, thereby promoting hepatic steatosis ...
Li Xu, Zhenyang Xu, Chenli Su, Yanqian Zhao, Linjing Qiang, Xiayong Jing, Yuxiang Sun   +6 more
wiley   +1 more source

Carvacrol Mitigates TNF‐α‐Driven Oxidative and Bioenergetic Impairment in L6 Rat Myoblasts

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Carvacrol (6.25 µg/mL) attenuates TNF‐α‐induced bioenergetic toxicity in L6 rat myoblasts by reducing LDH release by 79%, quenching intracellular ROS, partially restoring mitochondrial membrane potential and ion‐dependent ATPase activities, recovering catalase and SOD function, and upregulating SIRT1 and AMPK mRNA—identifying carvacrol as a multi ...
Ali M. Albarrati, Rakan I. Nazer
wiley   +1 more source

Exercise triggers integrated lipid, sphingolipid and purine metabolic alterations in midlife women. [PDF]

Front Physiol
Almuraikhy S, Sellami M, Naja K, Anwardeen N, Al-Sulaiti H, Elhag HEEA, Elrayess MA.   +6 more
europepmc   +1 more source

Inhibition of Tropomyosin Receptor Kinase B Signaling Alters Hepatic Mitochondrial Enzyme Activity and Oxidative Stress in Mice With Sucrose‐Induced Insulin Resistance

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Suppression of BDNF‐TrkB signaling has shown a protective trend on hepatic oxidative stress by reducing sucrose‐induced lipid peroxidation. BDNF–TrkB signaling pathway plays a peripheral role in regulating mitochondrial enzyme capacity and redox balance in the liver.
Akın Bodur, Hüseyin Çınar Zihni, Katip Korkmaz, Solmaz Bodur, Ahmet Alver   +4 more
wiley   +1 more source

Integrated multi-omic analyses reveal novel gene-metabolite relationships in human steatohepatitic hepatocellular carcinoma. [PDF]

J Lipid Res
Anspach GB, Flight RM, Park S, He D, Wang C, Moseley HNB, Helsley RN.   +6 more
europepmc   +1 more source

Small Extracellular Vesicle and Total Lipid Profiles Provide a Diagnostic Advantage Over CA‐125 Across Ovarian Cancer Subtypes

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
Small extracellular vesicle (sEV) lipid profiles outperform CA‐125 across ovarian cancer histotypes, achieving accuracy up to 0.73 in differential diagnosis and 0.94 in screening. In patients with normal CA‐125 levels, sEV lipids maintain discriminative performance where CA‐125 alone fails. ABSTRACT Ovarian cancer remains the most lethal gynaecological
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Lewis Perrin, Rohan Lourie, Vaibhavi Joshi, Amy E. McCart Reed, Kaltin Ferguson, Aase Handberg, Andreas Möller, Carlos Salomon   +11 more
wiley   +1 more source