Results 221 to 230 of about 32,676 (287)

1-Deoxysphingolipids require very-long-chain ceramide synthesis to induce ER stress and cytotoxicity. [PDF]

J Biol Chem
Byrnes C, Clarke BA, Zhu H, Lee YT, Majumder S, Kono M, Proia RL.   +6 more
europepmc   +1 more source

Sex‐dependent effects of a high‐fat diet‐induced obesity model on cerebrovascular health and brain metabolism

Experimental Physiology, Volume 111, Issue 11, Page 5236-5249, 1 November 2026.
Abstract Mid‐life obesity is a major risk factor for neurodegenerative diseases, with mitochondrial and cerebrovascular dysfunction considered key mediators. Lysine acetylation is a reversible post‐translational modification that regulates several mitochondrial metabolic and biochemical processes.
Nicole N. Eminhizer, Dena Lin, Alec Hanshew, Jackson Stewart, Steven Ball, Christa Lilly, Saina S. Prabhu, Kate Karelina, Eric E. Kelley, Randy W. Bryner, Dharendra Thapa, Paul D. Chantler   +11 more
wiley   +1 more source

LC-MS/MS Quantification and Comparative Profiling of Stratum Corneum Ceramides in Human Normal and Dry Skin Subtypes. [PDF]

Metabolites
Xie A, Zhao Y, Zhao Y, Zhao X, Zhu X, Wang J.   +5 more
europepmc   +1 more source

Loss of Acid Ceramidase in Myeloid Cells Protects From Chronic Colitis in IL10‐Deficient Mice

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
Acid ceramidase converts ceramide to sphingosine which can then be converted to sphingosine‐1‐phosphate, a bioactive lipid involved in inflammation. Loss of acid ceramidase in myeloid cells protects from chronic colitis by reducing pro‐inflammatory markers, increasing ceramides, and reducing effector immune cells in the colon.
Keila S. Espinoza, Brandon K. Dahl, Ella M. Ryan, Mary R. Gordon, Chelsea L. Doll, Marilyn T. Marron, Cameron A. Beard, Pujarini D. Dey, David G. Besselsen, Richard J. Simpson, Justin M. Snider, Justin E. Wilson, Pawel R. Kiela, Ashley J. Snider   +13 more
wiley   +1 more source

Serum Metabolomic Profiling Reveals Potential Mechanisms and Biomarkers of Seladelpar Treatment in Patients With Primary Biliary Cholangitis. [PDF]

PPAR Res
Choi YJ, Schwab A, Lim J, Carlisle SM, McWherter CA, Johnson JD.   +5 more
europepmc   +1 more source

Design Considerations for Polymer–Deep Eutectic Solvent Hybrid Systems for Transdermal Drug Delivery

Journal of Applied Polymer Science, Volume 143, Issue 40, October 20, 2026.
Deep eutectic solvents (DESs) act as tunable, green excipients that modulate polymer structure–property relationships to enhance drug solubility, skin permeation, stability, and controlled release. Through hydrogen‐bond interactions, DES–polymer hybrid systems enable improved transdermal performance, offering a rational, design‐driven platform for ...
Madhavi Kailas Kapale, Madhur Kulkarni, Pranav J. Shah, Furqan A. Maulvi   +3 more
wiley   +1 more source

Ceramides as Biomarkers and Pharmacological Targets in Heart Failure Pathophysiology. [PDF]

Biomolecules
Gaggini M, Vassalle C.
europepmc   +1 more source

The p53-CerS6 interaction on the ER integrates p53 and sphingolipid signaling pathways in metabolic stress response. [PDF]

J Lipid Res
Childress MS, Jeffries KA, Horita DA, Krupenko SA, Krupenko NI.   +4 more
europepmc   +1 more source

Inhibition of acid sphingomyelinase links sphingolipid remodeling to necroptotic cell death. [PDF]

RSC Chem Biol
Pilapil LAE, Chitkara S, Atilla-Gokcumen GE.   +2 more
europepmc   +1 more source