Results 201 to 210 of about 32,676 (287)
ABSTRACT Background Distal symmetrical polyneuropathy (DSPN) is a common complication of type 1 diabetes (T1D), yet validated biomarkers for early detection or prognosis are lacking. Metabolic disturbances driven by chronic hyperglycemia and dyslipidemia contribute to DSPN development and progression.
Tik Muk +18 more
wiley +1 more source
Extracellular Vesicles in Dermatology: Where Are We and What Lies Ahead?
ABSTRACT Extracellular vesicles (EVs) have emerged as key players in skin biology, mediating intercellular communication across diverse physiological and pathological contexts. In this review, we critically assess the current understanding of EVs in dermatology, highlighting their roles in skin homeostasis, ageing, inflammation, wound healing and ...
Ines Martic +14 more
wiley +1 more source
Proteomic Analysis of Sphingolipid Metabolic Enzymes with Risk of Bladder Cancer Incidence and Mortality in the Atherosclerosis Risk in Communities Study. [PDF]
Marrone MT +6 more
europepmc +1 more source
Inhibition of 3‐Phosphoinositide‐Dependent Kinase 1 Improves Age‐Associated Epidermal Dysfunction
ABSTRACT Epidermal aging is characterized by impaired homeostasis, including reduced cell proliferation, aberrant differentiation, deterioration of the dermal–epidermal junction (DEJ), and compromised barrier function. Accumulating evidence suggests that these alterations arise not solely from intrinsic stem cell loss but from disruption of regulatory ...
Si‐Young Cho +9 more
wiley +1 more source
IL-4/IL-13-Driven Dysregulation of Epidermal Lipid Metabolism in Atopic Dermatitis: An Immunometabolic Link Between Type 2 Inflammation and Barrier Dysfunction. [PDF]
Andrzejczak K +5 more
europepmc +1 more source
Pantethine Restores Epidermal Homeostasis and Modulates Vesicle‐Associated Proteins in Psoriasis
Pantethine attenuates psoriasis‐like epidermal pathology in a full‐thickness 3D human skin model by modulating inflammatory, oxidative‐stress, differentiation and tissue‐remodelling responses, alongside changes in vesicle‐associated proteins. These findings support restoration of epidermal homeostasis, although direct effects on extracellular vesicles ...
Passanesh Sukphopetch +7 more
wiley +1 more source
Lipid Metabolic Reprogramming and Bioactive Lipid Signaling in MASLD: Molecular Mechanisms, Pathogenesis and Therapeutic Opportunities. [PDF]
Ábel T, Csobod Csajbókné É.
europepmc +1 more source
In vivo ATR‐FTIR measurements revealed that hair wash frequency significantly affects the accumulation of sebum and skin residues on the scalp. When washing habits are standardized across different hair types, scalp sebum levels and composition are influenced by age, not by hair type.
Samuel Gourion‐Arsiquaud +2 more
wiley +1 more source

