Results 181 to 190 of about 32,676 (287)

Caloric restriction improves glycemic control via the adiponectin-ceramide axis in non-obese men and women: the CALERIE™ 2 randomized controlled trial. [PDF]

Nat Commun
Warmbrunn MV, Biswas RK, Don AS, Lastra Cagigas M, Li Y, Yang L, Twigg SM, Fiorito G, Fontana L.   +8 more
europepmc   +1 more source

Extracellular Vesicles for Space Biomedical Research

Journal of Extracellular Vesicles, Volume 15, Issue 11, November 2026.
Microgravity reshapes EV biogenesis and cargo selection, which brings new opportunities for longitudinal liquid‐biopsy readouts of stress and aging‐like trajectories, as well as the regenerative products in spaceflight research. ABSTRACT Extracellular vesicles (EVs) are regulated, information‐rich nanovesicles that reflect aspects of parent‐cell state,
Samantha Ali, Brian I. Molina Diaz, Pei Zhuang, Zachary Greenberg, Ye Zhang, Jeffrey Richards, Danny Carlos, Stefanie Countryman, Christiaan Leeuwenburgh, Luke P. Lee, Mei He   +10 more
wiley   +1 more source

Ceramides and Type 2 Diabetes: A Scoping Review of Mechanisms, Insulin Resistance, and Nutritional Interventions. [PDF]

Cureus
Collins K, Chawla J, Krishnakumar P.
europepmc   +1 more source

Matrix Vesicle‐Associated SMS2 as a Novel Mediator of Biomineralization

Journal of Extracellular Biology, Volume 5, Issue 11, November 2026.
ABSTRACT SGMS2, a gene encoding plasma membrane‐resident sphingomyelin synthase 2, SMS2, has emerged as an important determinant of skeletal ossification. Heterozygous SGMS2 variants are associated with a broad spectrum of bone phenotypes, ranging from rickets‐like deformities in childhood to early‐onset osteoporosis, implicating SMS2 in mineralization
Phillip T. Newton, Mathieu Y. Brunet, Jose G. Marchan‐Alvarez, Outi Mäkitie, Joost C. M. Holthuis   +4 more
wiley   +1 more source

Apical proximal tubule fatty acid uptake-generated ceramides cause endoplasmic reticulum stress from altered membrane fluidity. [PDF]

JCI Insight
Liu Z, Gaivin RJ, Khan S, Li V, Chaba A, Moss FJ, Sabir U, Kasumov T, Mu T, Schelling JR.   +9 more
europepmc   +1 more source

Comparing the Independent Effects of Weight Loss or Exercise Training on Skeletal Muscle Lipid Localization and Insulin Sensitivity in Humans. [PDF]

Diabetes
Zarini S, Zemski Berry K, Garfield A, Macias E, Jambal P, Bowen S, Cree MG, Snell-Bergeon JK, Johnson C, Neufer PD, Tamburini I, Seldin M, Bergman BC.   +12 more
europepmc   +1 more source

The Role of Astrocytes in the Inflammatory Response in Neurodiseases

MedComm, Volume 7, Issue 11, November 2026.
Reactive astrocyte‐mediated pathogenic mechanisms in neurodegenerative diseases Schematic representation of key astrocytic pathways contributing to pathology in the pathogenesis of AD, PD, ALS, and HD. In AD, astrocytes exhibit Aβ plaque‐associated activation characterized by GFAP/S100β upregulation, accompanied by impaired EAAT2‐mediated glutamate ...
Shijun Peng, Lepeng Wang, Jia Ouyang, Ruen Liu   +3 more
wiley   +1 more source

Ceramides and the Defective Barrier in Atopic Dermatitis.

Skin Pharmacol Physiol
Wertz PW, Fluhr JW.
europepmc   +1 more source

Liver-derived ceramides link metabolism to tissue wasting in cancer cachexia. [PDF]

J Clin Invest
Huang K, Perrimon N, Goncalves MD.
europepmc   +1 more source

Exosomes in Cancer: The Biology, Function, Diagnosis, and Therapy

MedComm, Volume 7, Issue 11, November 2026.
Tumor‐derived exosomes and nonmembranous extracellular nanoparticles (exomeres/supermeres) constitute a heterogeneous communication network that drives cancer progression. By shuttling functional biomolecules across tissue‐specific barriers, these nanoparticles orchestrate local microenvironmental remodeling, immune suppression, premetastatic niche ...
Jun Wu, Lei Wu, Kang Yang, Kang Xie, Tao Lu, Tiangxiang Huang, Dengfeng Wan, Tao Song, Longbo Zhang   +8 more
wiley   +1 more source