Results 191 to 200 of about 32,676 (287)

Ceramide: a pivotal lipid mediator shaping female reproductive homeostasis and pathophysiology. [PDF]

J Ovarian Res
Wang W, Zhang F, Huang L, Qiao J, Qi X.
europepmc   +1 more source

Impact of Dupilumab Therapy on Skin Barrier Function in Patients With Moderate‐to‐Severe Atopic Dermatitis: A Phase IV, Non‐Randomized, Open‐Label, Parallel‐Group Clinical Study

MedComm, Volume 7, Issue 11, November 2026.
This 16‑week study assessed impact of dupilumab on skin barrier function in patients with moderate‑to‑severe atopic dermatitis (AD). Tape‑stripped stratum corneum samples for multi‑omic profiling, alongside transepidermal water loss measurements, were collected from lesional/non‑lesional AD skin and healthy controls at seven time points.
Taoming Liu, Shuting Chen, Weijia Zhao, Dake Di, Jiao Liu, Yuyang Tian, Yurong Luo, Yingping Xu, Ruzeng Xue, Li Ye, Xiaoping Pei, Bihui Yu, Yu Wang, Jiao Zhang, Xiaoling Yu, Wei Wen, Liyan Yuan, Suyun Ji, Claire Hu, Dan Shen, Yiqing Guo, Yunsheng Liang   +21 more
wiley   +1 more source

Ceramides in the Heart: Physiological and Pathological Roles and Regulation. [PDF]

Cells
Chen X, Fonseka O, Han Y, Liu W.
europepmc   +1 more source

Functional Characterization and Application of Yarrowia lipolytica YlYxc1 for Enhanced Production of Sphingoid Bases

Microbial Biotechnology, Volume 19, Issue 11, November 2026.
YlYxc1, an ER‐associated alkaline ceramidase of Yarrowia lipolytica, has the hydrolytic activity of ceramides, which can be exploited as a metabolic engineering target to enhance long‐chain base production. ABSTRACT Long‐chain bases (LCBs; sphingoid bases), derived from ceramide metabolism, are valuable sphingolipid intermediates for industrial ...
Seo Hyeon Shin, Eun Joo Jeon, Hye Yun Moon, Ga Yeong Go, Young Seo Yoo, Jae Kyeong Lee, Che Ok Jeon, Hyun Ah Kang   +7 more
wiley   +1 more source

Sphingolipid and ceramide associations with tau pathology vary across diverse ethnoracial groups in postmortem brain tissue. [PDF]

Alzheimers Dement
Schweickart A, Batra R, Huynh K, Blach C, Kueider-Paisley A, Reddy JS, Bennett DA, Meikle PJ, Zhang B, De Jager PL, Heath L, Beck J, Scanlan J, Seyfried NT, Dickson DW, Ertekin-Taner N, Alzheimer's Disease Metabolomics Consortium, Kaddurah-Daouk R, Arnold M, Krumsiek J.   +19 more
europepmc   +1 more source

MKP‐2 Genetic Depletion Modulates Adipose Lipid Composition, Cellular Senescence, and Aging in Mice

Aging Cell, Volume 25, Issue 11, November 2026.
Excess white adipose tissue (WAT) accumulation promotes aging by increasing the risk of insulin resistance and chronic diseases and reduced lifespan. MKP‐2 deficiency protects against premature senescence in cells and WAT and is associated with adipose lipid remodeling, improved metabolic health, and longer lifespan.
Morgan Welch, Nabin Ghimire, Shauri Smith, Cassandra Secunda, Alexis Fink, Alissar Sleiman, Laura Chambliss, Christopher Pinckard, Chloe Reyes, Priya Katta, Anna Ai, Benjamin R. Harrison, Ahmed Lawan   +12 more
wiley   +1 more source

Antitumor Activity of Liposomal Nanoparticles Co-Encapsulating Ceramides and Doxorubicin in In Vitro Nucleolin-Expressing Neuroblastoma Models. [PDF]

Cells
Bensa V, Lopes-Cardoso H, Ardito M, Ciampi E, Voronovska A, Soares-Gonçalves J, Ponzoni M, Brignole C, Moreira JN, Pastorino F.   +9 more
europepmc   +1 more source

Post‐Occlusion Application of Skin Protective Creams Does Not Affect Occlusion‐Induced Barrier Changes: A Randomized Controlled Experimental Study

Contact Dermatitis, Volume 95, Issue 5, Page 437-449, November 2026.
Post‐occlusion application of protective creams did not consistently reduce occlusion‐induced skin barrier impairment after glove use. Protective efficacy probably depends on formulation and timing, with only immediate pre‐irritant application showing a significant reduction in SLS‐induced barrier disruption.
Michal Gina, Katharina Wichert, Thomas Behrens, Thomas Brüning, Julia Krabbe   +4 more
wiley   +1 more source

Sphingolipids and Mortality in Hemodialysis: Innocent Bystanders or Causal Culprits? [PDF]

J Am Soc Nephrol
Saum KL, Pennathur S.
europepmc   +1 more source