Results 161 to 170 of about 23,396 (211)
Some of the next articles are maybe not open access.
2004
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a clinically useful cytokine. TRAIL induces apoptosis in a wide variety of transformed cells, but does not cause toxicity to most normal cells. Recent studies show that death receptors (DR4 and DR5), decoy receptors (DcR1 and DcR2), and death inhibitors (FLIP, FAP-1, and IAP) are ...
Yong J, Lee, Andrew A, Amoscato
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Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a clinically useful cytokine. TRAIL induces apoptosis in a wide variety of transformed cells, but does not cause toxicity to most normal cells. Recent studies show that death receptors (DR4 and DR5), decoy receptors (DcR1 and DcR2), and death inhibitors (FLIP, FAP-1, and IAP) are ...
Yong J, Lee, Andrew A, Amoscato
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Molecular and Cellular Endocrinology, 2022
Sphingolipids are essential lipid components in the intestinal epithelial cells (IEC) along the intestinal tract. They play crucial roles in maintaining barrier integrity, regulating nutrient absorption, and acting as signaling molecules to regulate regeneration and differentiation of intestinal mucosa (Kurek et al., 2012).
Ying Li +2 more
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Sphingolipids are essential lipid components in the intestinal epithelial cells (IEC) along the intestinal tract. They play crucial roles in maintaining barrier integrity, regulating nutrient absorption, and acting as signaling molecules to regulate regeneration and differentiation of intestinal mucosa (Kurek et al., 2012).
Ying Li +2 more
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Bacterial Infections and Ceramide
2013Ceramide is released from sphingomyelin primarily by the activity of acid, neutral, or alkaline sphingomyelinases or is synthesized de novo. Several bacteria, viruses, and even parasites infect mammalian cells by exploiting the acid sphingomyelinase or the neutral sphingomyelinase-ceramide system, or both. Sphingomyelinases and ceramide have been shown
Grassmé, Heike, Becker, Katrin Anne
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2013
Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) molecule; these mutations result in a defect in chloride secretion in epithelial cell layers. The disease is characterized by severe gastrointestinal and pulmonary symptoms, but it is the pulmonary symptoms that dominate the clinical course of the ...
Grassmé, Heike +2 more
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Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) molecule; these mutations result in a defect in chloride secretion in epithelial cell layers. The disease is characterized by severe gastrointestinal and pulmonary symptoms, but it is the pulmonary symptoms that dominate the clinical course of the ...
Grassmé, Heike +2 more
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2015
Are ceramide molecules capable of self-assembling in biological and phospholipid membranes to form ceramide channels: membrane channels capable to translocating proteins through said membranes? A number of papers have been published which support the conclusion that ceramide forms these large channels in membranes.
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Are ceramide molecules capable of self-assembling in biological and phospholipid membranes to form ceramide channels: membrane channels capable to translocating proteins through said membranes? A number of papers have been published which support the conclusion that ceramide forms these large channels in membranes.
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Molecular Dynamics Simulations of Ceramide and Ceramide-Phosphatidylcholine Bilayers
The Journal of Physical Chemistry B, 2017Recent studies in lipid raft formation and stratum corneum permeability have focused on the role of ceramides (CER). In this study, we use the all-atom CHARMM36 (C36) force field to simulate bilayers using N-palmitoylsphingosine (CER16) or α-hydroxy-N-stearoyl phytosphingosine (CER[AP]) in 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) or 1 ...
Eric Wang, Jeffery B. Klauda
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Constituents of ceramide and ceramide monohexoside in rice bran
Chemistry and Physics of Lipids, 1976Abstract Previous studies in our laboratory [1,2] indicated the existence of ceramides and ceramide monochexosides in brown rice grain. More recently, we have obtained evidence for the presence of these and other sphingolipids (ceramide dihexosides and ceramide trihexosides) in rice bran.
Y. Fujino, M. Ohnishi
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Ceramide in Chemotherapy of Tumors
Recent Patents on Anti-Cancer Drug Discovery, 2011It is well known that tumor formation arises from the imbalance between cell death and proliferation. For many years, cancer research has engaged an important part of its efforts to find new therapeutic strategies based on cell death induction. One of the predominant ways to kill tumor cells is to trigger apoptosis by chemotherapy.
Dimanche-Boitrel, Marie-Thérèse +2 more
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A micromethod for the determination of ceramide
Journal of Neuroscience Methods, 1982An enzymatic micromethod for the determination of ceramide is presented. The enzyme, E. coli diglyceride kinase was used to phosphorylate ceramide, as well as diglyceride with high specific activity gamma-[32P]ATP, and the two products are differentiated by their alkali stability.
M, Jones, R W, Keenan
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Ceramide and Ceramide 1 Phosphate in the Brain
2011Ceramide (N-acylsphingosine) forms the backbone of all complex sphingolipids. It is composed of the long-chain sphingoid base, sphingosine, in N-linkage to a variety of acyl groups (varying in length from C14 to C26) (Fig. 8.1). In addition to serving as a precursor to complex sphingolipids, ceramide is a potent signaling molecule capable of regulating
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