Results 141 to 150 of about 32,676 (287)

Synthesis and study of 6-hydroxysphingosine-based ceramides

, 2013
Ceramides, belonging to large family of sphingolipids, play a significant role in many processes in living systems. They participate in both physiological and pathophysiological processes (cell signalization). In addition, they are essential in the human
Kováčik, Andrej
core  

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Long and Very-Long-Chain Ceramides Correlate with A More Aggressive Behavior in Skull Base Chordoma Patients

, 2019
Background: Skull base chordomas are rare tumors arising from notochord. Sphingolipids analysis is a promising approach in molecular oncology, and it has never been applied in chordomas.
Morgan Broggi, Chiara Calatozzolo, Alberto Raggi, Monica Patanè, Rita Paroni, Emanuele La Corte, Paolo Ferroli, Giuseppe Campisi, Silvia Schiavolin, Maria Grazia Bruzzone, Michele Dei Cas, Riccardo Ghidoni, Carlotta Pipolo, Bianca Pollo   +13 more
core   +1 more source

Advances in Radiotherapy for Neoadjuvant Therapy of Stage III Non‐Small Cell Lung Cancer

Cancer Science, EarlyView.
This review summarizes three neoadjuvant radiotherapy techniques for stage III NSCLC, highlighting SFRT's low‐toxicity dual immune‐tumor control benefits and radioimmunotherapy's superior pathological response to guide precise multimodal treatment. ABSTRACT This review aims to systematically summarize the mechanisms of action, clinical evolution, and ...
Qinrong Mao, Yuanchun Yu, Yan Fang, Shaofeng Zhu, Chengjin Tang, Jing Cai   +5 more
wiley   +1 more source

Gut microbiota dysbiosis-mediated ceramides elevation contributes to corticosterone-induced depression by impairing mitochondrial function

npj Biofilms and Microbiomes
The role of gut microbiota (GM) dysbiosis in the pathogenesis of depression has received widespread attention, but the mechanism remains elusive. Corticosterone (CORT)-treated mice showed depression-like behaviors, reduced hippocampal neurogenesis, and ...
Guanhao Wang, Lining Cao, Shuanqing Li, Meihui Zhang, Yingqi Li, Jinjin Duan, You Li, Zhangsen Hu, Jiaan Wu, Jianbo Ni, Danmei Lan, Tianming Li, Jianfeng Lu   +12 more
doaj   +1 more source

Ceramides, Particularly Those Containing Very‐Long‐Chain Saturated Fatty Acids, Are Independently Associated With the Triglyceride–Glucose Index in European Individuals With Type 2 Diabetes

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims The triglyceride–glucose (TyG) index is associated with insulin resistance and cardiovascular disease (CVD), but the underlying mechanisms remain unclear. As ceramides are implicated in both insulin resistance and CVD, we investigated the association between the TyG index and plasma ceramides in individuals with Type 2 diabetes (T2D ...
Laure Carpentier, Damien Denimal, Alexia Rouland, Jean‐Michel Petit, Jean Paul Pais de Barros, Laurence Duvillard, Benjamin Bouillet, Bruno Vergès   +7 more
wiley   +1 more source

A lipid‐sensitive food choice behavior influences aging outcomes from a longevity‐promoting diet

The FEBS Journal, EarlyView.
C. elegans are exposed to a variety of bacteria in their natural environment and must be able to distinguish between beneficial and detrimental food sources. We show that C. elegans exposed to the bacterium from their natural habitat, Methylobacterium, disrupts lipid homeostasis, causing worms to avoid this bacterial species and choose the laboratory ...
Nicole L. Stuhr, Carmen M. Ramos, Chris D. Turner, Alexander A. Soukas, Sean P. Curran   +4 more
wiley   +1 more source

A film of tuberose polysaccharide supports normal epidermal keratinization by suppressing cytokine release induced by external stimuli

International Journal of Cosmetic Science, EarlyView.
(a) Dry, rough skin has an immature stratum corneum prone to stimuli, triggering IL‐1α/IL‐1ra/IL‐8 release, keratinization defects, reduced ceramide NP/NS and lipids, scaling and poor hydration. (b) TPS forms a flexible reticular film, shielding the SC, lowering cytokines, normalizing differentiation, restoring lipids and improving texture and water ...
Junko Ishikawa, Yuka Yasuda
wiley   +1 more source

Systemic Lipidomics Identifies Altered Ceramide–Phospholipid Balance Associated With Periodontitis Severity: A Cross‐Sectional Study With 12‐Year Follow‐Up

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To investigate whether periodontitis stage and grade are associated with circulating active lipid mediators and whether baseline lipid species predict periodontitis progression. Materials and Methods The study included 473 Finnish participants from the Parogene cohort undergoing coronary angiography, with 12‐year follow‐up data available ...
Minja Tuomivaara, Anne‐Mari Halme, Muhammed Manzoor, Elina Salasuo, Susanna Paju, Päivi Mäntylä, Kåre Buhlin, Laura Lahdentausta‐Suomalainen, Reijo Laaksonen, Juha Sinisalo, Pirkko Pussinen, Aino Salminen   +11 more
wiley   +1 more source

Ceramid [PDF]

, 2018
K. J. Lackner, D. Peetz
openaire   +2 more sources