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Enhanced ceramide-induced apoptosis in ceramide kinase overexpressing cells
Biochemical and Biophysical Research Communications, 2007We evaluated how increased levels of ceramide kinase (CerK) would impact the growth of COS-1 fibroblasts and RBL-2H3 basophils. The low CerK activity in these cells was strongly up-regulated upon recombinant expression of CerK. CerK-overexpressing COS-1 cells depended on higher concentrations of serum for their growth and displayed many filipodia.
Christine, Graf +4 more
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Bacterial Infections and Ceramide
2013Ceramide is released from sphingomyelin primarily by the activity of acid, neutral, or alkaline sphingomyelinases or is synthesized de novo. Several bacteria, viruses, and even parasites infect mammalian cells by exploiting the acid sphingomyelinase or the neutral sphingomyelinase-ceramide system, or both. Sphingomyelinases and ceramide have been shown
Grassmé, Heike, Becker, Katrin Anne
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2013
Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) molecule; these mutations result in a defect in chloride secretion in epithelial cell layers. The disease is characterized by severe gastrointestinal and pulmonary symptoms, but it is the pulmonary symptoms that dominate the clinical course of the ...
Grassmé, Heike +2 more
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Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) molecule; these mutations result in a defect in chloride secretion in epithelial cell layers. The disease is characterized by severe gastrointestinal and pulmonary symptoms, but it is the pulmonary symptoms that dominate the clinical course of the ...
Grassmé, Heike +2 more
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Studies on galactosyl ceramide and lactosyl ceramide β-galactosidase
Chemistry and Physics of Lipids, 1974Abstract Galactosyl ceramide and lactosyl ceramide β-galactosidase activity was measured in extracts of previously frozen human brain. Using the assay methods described here, both galactosyl ceramide and lactosyl ceramide gave Michaelis constants of about 20 μM.
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Ceramide second messengers and ceramide assays
Trends in Biochemical Sciences, 1999J D, Watts +4 more
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Arteriosclerosis, thrombosis, and vascular biology, 2019
Objective- Ceramides are sphingolipids involved with cellular signaling. Synthesis of ceramides occurs in all tissues. Ceramides accumulate within tissues and the blood plasma during metabolic dysfunction, dyslipidemia, and inflammation. Elevations of ceramides are predictive of cardiovascular mortality.
Jeffrey W, Meeusen +5 more
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Objective- Ceramides are sphingolipids involved with cellular signaling. Synthesis of ceramides occurs in all tissues. Ceramides accumulate within tissues and the blood plasma during metabolic dysfunction, dyslipidemia, and inflammation. Elevations of ceramides are predictive of cardiovascular mortality.
Jeffrey W, Meeusen +5 more
openaire +1 more source