Results 91 to 100 of about 624,789 (324)

Calcineurin controls the expression of numerous genes in cerebellar granule cells [PDF]

, 2003
The Ca(2+)/calmodulin-dependent phosphatase calcineurin plays a crucial role in gene expression in different cell types such as T-lymphocytes, cardiac myocytes, and smooth muscle cells.
Fresu, Luigia, Ashby, Dominique S, Freeman, Tom C, Genazzani, Armando A, Kramer, Dana   +4 more
core  

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

PAPILLARY GLIONEURONAL TUMOR OF THE POSTERIOR FOSSA

Revista Ciencias Biomédicas, 2015
Introduction: the papillary glioneuronal tumor (PGT) is an uncommon disease and it has recent categorization. It has probable origin in the pluripotent stem cells of the subependymal zone that is located mainly around the temporal horns of the lateral
Tuñón-Pitalúa Martha Cecilia, Ruiz-Cáez Karina María, Niño-Hernández Lucía Mercedes, Benedetti-Isaac Juan Carlos, Alcalá-Cerra Gabriel, Remolina-López Anderson Julián   +5 more
doaj  

Benchmarking Cerebellar Control [PDF]

, 2000
Cerebellar models have long been advocated as viable models for robot dynamics control. Building on an increasing insight in and knowledge of the biological cerebellum, many models have been greatly refined, of which some computational models have ...
Smagt van der, P., van der Smagt, Patrick   +1 more
core  

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

An Uncommon Occurrence of Posterior Fossa Ependymoma in Elderly Patient: A Case Report

Düzce Tıp Fakültesi Dergisi
Cerebellar ependymomas are rare neoplasms, even more so in elderly patients. In this case report, a 75-year-old male patient admitted with a one-year history of progressive general decline, urinary retention, left-sided weakness, memory loss, and ...
Taşkın Yurtseven, Mustafa Serdar Bölük, Hüseyin Biçeroğlu, Bilal Bahadır Akbulut   +3 more
doaj   +1 more source

Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum.

Genes & Development, 2000
Medulloblastomas are among the most common malignancies in childhood, and they are associated with substantial mortality and morbidity. The molecular pathogenesis as well as the ontogeny of these neoplasms is still poorly understood.
S. Marino, M. Vooijs, H. van der Gulden, J. Jonkers, A. Berns   +4 more
semanticscholar   +1 more source

Mucinous Neoplasms

, 2014
Although interest in pancreatic pathology is very high in the radiological and gastroenterological communities, it is still the case that less is known about pathology of the pancreas than about liver pathology, for example.
D'ONOFRIO, Mirko, Paolo Tinazzi Martini, Giovanni Morana, Crosara, Stefano, Riccardo De Robertis, Emilio Barbi, Capelli, Paola, MORANA, Giovanni, Paola Capelli, DE ROBERTIS LOMBARDI, Riccardo, Barbi, Emilio, TINAZZI MARTINI, Paolo, LUCHINI, Claudio, Mirko D’Onofrio, Claudio Luchini, Stefano Crosara   +15 more
core   +1 more source

Design, Control, and Clinical Applications of Magnetic Actuation Systems: Challenges and Opportunities

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
This review aims to provide a broad understanding for interdisciplinary researchers in engineering and clinical applications. It addresses the development and control of magnetic actuation systems (MASs) in clinical surgeries and their revolutionary effects in multiple clinical applications.
Yingxin Huo, Lidong Yang, Tiantian Xu, Dong Sun   +3 more
wiley   +1 more source

Immune Modulatory Therapy for Severe Dengue Hemorrhagic Fever in a Patient With Mitochondrial Complex I Deficiency: A Case Report

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Dengue virus (DENV) poses a serious global health challenge, particularly in cases of dengue hemorrhagic fever (DHF). Patients with preexisting mitochondrial disorders may be at increased risk for complications due to the specific impact of DENV on mitochondrial‐dependent cellular processes and immune function.
Audra N. Iness, Ameya S. Walimbe, Emily R. Strouphauer, Michio Hirano, Alejandro D. Iglesias, Valentina Emmanuele, Caitlin C. Griffin, Sheldon L. Kaplan, William A. Gomes, Karen K. Moeller, Stephen F. Kralik, Fernando Scaglia   +11 more
wiley   +1 more source