Results 61 to 70 of about 27,277 (291)
Network-based association analysis to infer new disease-gene relationships using large-scale protein interactions. [PDF]
PLoS ONE, 2018 Protein-protein interactions integrated with disease-gene associations represent important information for revealing protein functions under disease conditions to improve the prevention, diagnosis, and treatment of complex diseases.
Apichat Suratanee, Kitiporn Plaimas
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Advanced Science, EarlyView.This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng +13 more
wiley +1 more source
Anti-Yo–associated paraneoplastic cerebellar degeneration revealing appendiceal adenocarcinoma: a case report with complete neurological recovery [PDF]
Journal of Neurocritical CareBackground Paraneoplastic cerebellar degeneration (PCD) is a rare immune-mediated disorder often linked to gynecologic or breast tumors, with anti-Yo antibodies being a key marker.
Ümitcan Ateş
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, 2023 A 68-year-old woman with positional dizziness and progressive imbalance presented for vestibular evaluation. Examination was notable for spontaneous downbeat nystagmus (DBN), horizontal and vertical gaze-evoked nystagmus (GEN) with centripetal and ...
N. E. F. Hac; O. C. Murphy; A. A. Butala; S. D. Newsome; D. R. Gold
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Advanced Science, EarlyView.STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang +8 more
wiley +1 more source
Erdheim-Chester disease presenting at the central nervous system
Autopsy and Case Reports, 2021 Erdheim-Chester disease is a rare non-Langerhans cell histiocytosis (LCH) that affects different body systems. It was recently recognized as a neoplastic disorder after identifying an activating mutation of the MAPK pathway. Neurological presentations of
Sydney Fasulo +9 more
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Arquivos de Neuro-Psiquiatria, 2007 OBJECTIVE: To report a case of ganglioneuroblastoma of cerebellum, with emphasis to the neuroimaging and pathological findings. CASE REPORT: A one year and eight-month-old girl presented with a two-month history of hypoactivity and tremor in the legs ...
Emerson L. Gasparetto +3 more
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Esophageal Gastrointestinal Stromal Tumor with Rare Intracranial Metastasis
Case Reports in Gastrointestinal Medicine, 2020 Introduction. Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors and constitute the largest group of nonepithelial digestive neoplasms. However, they do not represent more than 1% of primary digestive tumors.
José Carvalho +5 more
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Advanced Science, EarlyView.Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li +13 more
wiley +1 more source
PAPILLARY GLIONEURONAL TUMOR OF THE POSTERIOR FOSSA
Revista Ciencias Biomédicas, 2015 Introduction: the papillary glioneuronal tumor (PGT) is an uncommon disease and it has recent categorization. It has probable origin in the pluripotent stem cells of the subependymal zone that is located mainly around the temporal horns of the lateral
Tuñón-Pitalúa Martha Cecilia +5 more
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