The Cerebellar Nuclei and Dexterous Limb Movements. [PDF]
Neuroscience, 2020 Dexterous forelimb movements like reaching, grasping, and manipulating objects are fundamental building blocks of the mammalian motor repertoire. These behaviors are essential to everyday activities, and their elaboration underlies incredible accomplishments by human beings in art and sport. Moreover, the susceptibility of these behaviors to damage and
Thanawalla AR, Chen AI, Azim E.
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Cerebellar nuclei excitatory neurons regulate developmental scaling of presynaptic Purkinje cell number and organ growth. [PDF]
Elife, 2019 For neural systems to function effectively, the numbers of each cell type must be proportioned properly during development. We found that conditional knockout of the mouse homeobox genes En1 and En2 in the excitatory cerebellar nuclei neurons (eCN) leads
Willett RT +12 more
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Perineuronal Nets in the Deep Cerebellar Nuclei Regulate GABAergic Transmission and Delay Eyeblink Conditioning. [PDF]
J Neurosci, 2018 Perineuronal nets (PNNs), composed mainly of chondroitin sulfate proteoglycans, are the extracellular matrix that surrounds cell bodies, proximal dendrites, and axon initial segments of adult CNS neurons.
Hirono M +7 more
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Dynamic modulation of activity in cerebellar nuclei neurons during pavlovian eyeblink conditioning in mice. [PDF]
Elife, 2017 While research on the cerebellar cortex is crystallizing our understanding of its function in learning behavior, many questions surrounding its downstream targets remain.
Ten Brinke MM +9 more
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The Cerebellar Nuclei Take Center Stage [PDF]
The Cerebellum, 2011 Despite the central location of the cerebellar nuclei neurons (CN) and those in the vestibular nuclei (VN) that receive Purkinje cell input, the neuroscience community has addressed surprisingly little attention to neurons in these central structures ...
L. Witter +3 more
semanticscholar +4 more sources
Control of voluntary and optogenetically perturbed locomotion by spike rate and timing of neurons of the mouse cerebellar nuclei. [PDF]
Elife, 2018 Neurons of the cerebellar nuclei (CbN), which generate cerebellar output, are inhibited by Purkinje cells. With extracellular recordings during voluntary locomotion in head-fixed mice, we tested how the rate and coherence of inhibition influence CbN cell
Sarnaik R, Raman IM.
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Cerebellar Nuclear Neurons Use Time and Rate Coding to Transmit Purkinje Neuron Pauses. [PDF]
PLoS Computational Biology, 2015 Neurons of the cerebellar nuclei convey the final output of the cerebellum to their targets in various parts of the brain. Within the cerebellum their direct upstream connections originate from inhibitory Purkinje neurons. Purkinje neurons have a complex
Shyam Kumar Sudhakar +2 more
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Cerebellar nuclei neurons display aberrant oscillations during harmaline-induced tremor [PDF]
Heliyon, 2021 Summary: Essential tremor, a common, debilitating motor disorder, is thought to be caused by cerebellar malfunction. It has been shown that rhythmic Purkinje cell firing is both necessary and sufficient to induce body tremor.
Yuval Baumel, Hagar G. Yamin, Dana Cohen
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Cross-talk between dopamine and noradrenaline modulates glutamatergic transmission in the deep cerebellar nuclei [PDF]
Scientific ReportsModulation of synaptic transmission in the deep cerebellar nuclei, a major output region of the cerebellum, is essential for regulating motor and non-motor functions by controlling information flow from the cerebellar cortex.
Fumihito Saitow +2 more
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Operative Neurosurgery, 2020 BACKGROUND The cerebellum is one of the most primitive and complex parts of the human brain. The fiber microdissection technique can be extremely useful for neurosurgeons to understand the topographical organization of the cerebellum's important contents,
N. Pruthi, Paulo A S Kadri, U. Türe
semanticscholar +3 more sources