Results 151 to 160 of about 368,839 (349)
Bioprinted Organoids: An Innovative Engine in Biomedicine
Advanced Science, EarlyView.Bioprinted organoids refer to either the printing of stem cells into tissue shape and subsequent differentiate into organoids, or assembling induced organoids as bioinks to replicate native organ. It enables the creation of miniaturized organs with complex architectures and physiological functions, potentially enhancing reproducibility, throughput, and
Zhengwei Li +11 more
wiley +1 more source
Integration of Genetic and Imaging Data for Alzheimer's Disease Diagnosis and Interpretation
Advanced Science, EarlyView.AlzCLIP is a novel contrastive learning framework that integrates single nucleotide polymorphism (SNP) profiles and MRI‐derived imaging features into a unified representation space to improve Alzheimer's disease (AD) diagnosis and interpretation. By achieving superior diagnostic accuracy and revealing key genetic and structural contributors to AD risk,
Yanfei Wang +7 more
wiley +1 more source
Organization of reward and movement signals in the basal ganglia and cerebellum
Nature CommunicationsThe basal ganglia and the cerebellum are major subcortical structures in the motor system. The basal ganglia have been cast as the reward center of the motor system, whereas the cerebellum is thought to be involved in adjusting sensorimotor parameters ...
Noga Larry, Gil Zur, Mati Joshua
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New clues for the role of cerebellum in schizophrenia and the associated cognitive impairment
Frontiers in Cellular NeuroscienceSchizophrenia (SZ) is a complex neuropsychiatric disorder associated with severe cognitive dysfunction. Although research has mainly focused on forebrain abnormalities, emerging results support the involvement of the cerebellum in SZ physiopathology ...
Pawan Faris +4 more
doaj +1 more source
THE LATERAL RECESSES OF THE FOURTH VENTRICLE; THEIR RELATION TO CERTAIN CYSTS AND TUMOURS OF THE CEREBELLUM, AND TO OCCIPITAL MENINGOCELE [PDF]
, 1886 J. Bland Sutton
openalex +1 more source
Advanced Science, EarlyView.This study introduces two orthogonal sequencing methods, CMD1‐Deaminase sequencing (CD‐seq) and CMD1‐TET bisulfite sequencing (CT‐seq), that enable direct, independent detection of 5mC. Using these approaches together with ACE‐seq or TAB‐seq for 5hmC identification, the study reveals a significant reduction in 5hmC, but not 5mC, in the hippocampus of ...
Zi‐Xin Wang +15 more
wiley +1 more source
Advanced Science, EarlyView.A self‐developed CTC sorting and capture platform enabled single‐cell metabolomics of patient/animal CTCs, revealing brain/bone metastasis‐specific metabolic signatures. A classification model developed from these signatures predicted lung cancer metastasis risk, outperforming traditional markers and total CTC counts (AUCs:89 brain = 0.74; bone = 0.92).
Yang Xu +14 more
wiley +1 more source
PIEZO Force Sensing in Vascular Biology: An Explosion of New Knowledge, Concepts and Opportunity
Advanced Science, EarlyView.Knowledge of the remarkable mechanical force sensing and electrically transducing PIEZO1 and PIEZO2 channels is discussed across vascular biology and its cell types from the embryonic to adult stages in health, disease and old age. How the channels work, relate to other factors and signal for tissue responses to mechanical forces is debated.
David J Beech
wiley +1 more source