Results 31 to 40 of about 5,540 (198)

Synergistic Cytotoxicity of Lenalidomide and Dexamethasone in Mantle Cell Lymphoma via Cereblon-dependent Targeting of the IL-6/STAT3/PI3K Axis

EBioMedicine, 2017
At our center, relapsed mantle cell lymphoma (MCL) can be treated with maintenance therapy composed of consecutive low-dose lenalidomide and short-term, high-dose dexamethasone (LD regimen), which achieves good responses (longer overall survival and ...
Jiexian Ma, Kefei Wu, Weiya Bai, Xiaoxian Cui, Yan Chen, Youhua Xie, Yanhui Xie   +6 more
doaj   +1 more source

Research Progress on the Mechanism and Clinical Data of Cereblon 
in Reversing the Resistance of Lung Cancer to PD-1 Antibody by T cells

Chinese Journal of Lung Cancer, 2021
Programmed cell death receptor 1 (PD-1) is a membrance-spanning protein mostly expressed in the T cell, and combines with programmed cell death ligand 1 (PD-L1) in the targeting cell.
Jingjing GUO, Di MU, Ying HAN
doaj   +1 more source

Development of the first geldanamycin-based HSP90 degraders

Frontiers in Chemistry, 2023
Despite the early clinical promise, adverse events such as acquired resistance and dose-limiting toxicities have barred the widespread use of HSP90 inhibitors as anticancer drugs.
Silas Wurnig, Melina Vogt, Julian Hogenkamp, Niklas Dienstbier, Arndt Borkhardt, Sanil Bhatia, Finn K. Hansen   +6 more
doaj   +1 more source

CRL4-Cereblon complex in Thalidomide Embryopathy : a translational investigation [PDF]

, 2020
The Cereblon-CRL4 complex has been studied predominantly with regards to thalidomide treatment of multiple myeloma. Nevertheless, the role of Cereblon-CRL4 in Thalidomide Embryopathy (TE) is still not understood.
Recamonde-Mendoza, Mariana, Faccini, Lavinia Schuler, Paixão Côrtes, Vanessa Rodrigues, Garcia, Gabriela Barreto Caldas, Fraga, Lucas Rosa, Sanseverino, Maria Teresa Vieira, Kowalski, Thayne Woycinck, Vianna, Fernanda Sales Luiz, Gomes, Julia do Amaral   +8 more
core   +1 more source

Expression of the cereblon binding protein argonaute 2 plays an important role for multiple myeloma cell growth and survival [PDF]

, 2016
Background: Immunomodulatory drugs (IMiDs), such as lenalidomide, are therapeutically active compounds that bind and modulate the E3 ubiquitin ligase substrate recruiter cereblon, thereby affect steady-state levels of cereblon and cereblon binding ...
Stewart, Keith, Qinqin Xu, Lawrence J. Mandarino, Chang-Xin Shi, Erickson, Patrick, Hou, Yue-xian, Patrick Erickson, Xu, Qinqin, Ye Xu, Mandarino, Lawrence J., Moulun Luo, Keith Stewart, Langlais, Paul, Shi, Chang-Xin, Xu, Ye, James Zhu, Xiu-bao Chang, Yue-xian Hou, Luo, Moulun, Chang, Xiu-bao, Paul Langlais, Yuanxiao Zhu, Zhu, James, Zhu, Yuanxiao   +23 more
core   +2 more sources

Cereblon versus VHL: Hijacking E3 Ligases Against Each Other Using PROTACs [PDF]

, 2019
The von Hippel-Lindau (VHL) and cereblon (CRBN) proteins are substrate recognition subunits of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes.
Chiara, Maniaci, Alessio, Ciulli, Scott J., Hughes, Andrea, Testa, Miriam, Girardini   +4 more
core   +1 more source

Data for positive selection test and co-evolutionary analysis on mammalian cereblon

Data in Brief, 2019
Cereblon (CRBN) is a substrate recognition subunit of the CRL4 E3 ubiquitin ligase complex, directly binding to specific substrates for poly-ubiquitination followed by proteasome-dependent degradation of proteins.
Wataru Onodera, Toru Asahi, Naoya Sawamura   +2 more
doaj   +1 more source

Molecular mechanisms of cereblon-based drugs

Pharmacology & Therapeutics, 2019
Thalidomide, well known for its potent teratogenicity, has been re-evaluated as a clinically effective drug for the treatment of multiple myeloma. Although the direct target of thalidomide had been unclear until recently, we identified cereblon (CRBN) as a primary direct target of this drug by affinity purification using ferrite glycidyl methacrylate ...
Tomoko, Asatsuma-Okumura, Takumi, Ito, Hiroshi, Handa   +2 more
openaire   +3 more sources

Thalidomide mimics uridine binding to an aromatic cage in cereblon [PDF]

, 2014
Thalidomide and its derivatives lenalidomide and pomalidomide are important anticancer agents but can cause severe birth defects via an interaction with the protein cereblon.
Zanini, Fabio, Hartmann, Marcus D., Hernandez Alvarez, Birte, Coles, Murray, Coles, M., Hartmann, M., Hernandez Alvarez, B., Boichenko, Iuliia, Lupas, Andrei N., Zanini, F., Lupas, A., Hartmann, Marcus, Boichenko, I.   +12 more
core   +1 more source

Novel, thalidomide-like, non-cereblon binding drug tetrafluorobornylphthalimide mitigates inflammation and brain injury

Journal of Biomedical Science, 2023
Background Quelling microglial-induced excessive neuroinflammation is a potential treatment strategy across neurological disorders, including traumatic brain injury (TBI), and can be achieved by thalidomide-like drugs albeit this approved drug class is ...
Daniela Lecca, Shih-Chang Hsueh, Weiming Luo, David Tweedie, Dong Seok Kim, Abdul Mannan Baig, Neil Vargesson, Yu Kyung Kim, Inho Hwang, Sun Kim, Barry J. Hoffer, Yung-Hsiao Chiang, Nigel H. Greig   +12 more
doaj   +1 more source