Results 1 to 10 of about 54,104 (311)
Molecular Mechanisms of the Teratogenic Effects of Thalidomide
Pharmaceuticals, 2020 Thalidomide was sold worldwide as a sedative over 60 years ago, but it was quickly withdrawn from the market due to its teratogenic effects. Thalidomide was later found to have therapeutic effects in several diseases, although the molecular mechanisms ...
Tomoko Asatsuma-Okumura +2 more
exaly +4 more sources
Thalidomide in dermatology: Revisited
Indian Journal of Dermatology, 2015 The use of thalidomide in relation to dermatology is well- known and enough data is available in the literature about various aspects of thalidomide.
Iffat Hassan +2 more
doaj +4 more sources
Biochemistry and Biophysics Reports, 2021 Although thalidomide is highly teratogenic, it has been prescribed for treating multiple myeloma and Hansen's disease. However, its mechanism of action is not fully understood.
Maho Shimizu +6 more
doaj +1 more source
The Lancet, 2004 Despite its history as a human teratogen, thalidomide is emerging as a treatment for cancer and inflammatory diseases. Although the evolution of its clinical application could not have been predicted from the tragedy associated with its misuse in the past, its history serves as a lesson in drug development that underscores the need to understand the ...
Franks, Michael E. +2 more
openaire +2 more sources
Immunomodulation by thalidomide and thalidomide analogues [PDF]
Annals of the Rheumatic Diseases, 1999 Tumour necrosis factor α (TNFα), a key cytokine involved in the host immune response, also contributes to the pathogenesis of both infectious and autoimmune diseases. To ameliorate the pathology resulting from TNFα in these clinical settings, strategies for the inhibition of this cytokine have been developed.
L G, Corral, G, Kaplan
openaire +2 more sources
Biological evaluation of both enantiomers of fluoro-thalidomide using human myeloma cell line H929 and others. [PDF]
PLoS ONE, 2017 Over the last few years, thalidomide has become one of the most important anti-tumour drugs for the treatment of relapsed-refractory multiple myeloma. However, besides its undesirable teratogenic side effect, its configurational instability critically ...
Etsuko Tokunaga +5 more
doaj +1 more source
Frontiers in Physiology, 2021 Peritoneal angiogenesis is the key pathophysiological factor that limits peritoneal ultrafiltration during peritoneal dialysis (PD) in uremic patients.
Nan Zhu +8 more
doaj +1 more source
Antiangiogenic Activity and in Silico Cereblon Binding Analysis of Novel Thalidomide Analogs
Molecules, 2020 Due to its antiangiogenic and anti-immunomodulatory activity, thalidomide continues to be of clinical interest despite its teratogenic actions, and efforts to synthesize safer, clinically active thalidomide analogs are continually underway. In this study,
Megan L. Peach +12 more
doaj +1 more source
DESIGN, MOLECULAR MODELING AND SYNTHESIS OF NEW IMMUNOMODULATORY AGENTS FOR BIOLOGICAL STUDIES [PDF]
Al-Azhar Journal of Pharmaceutical Sciences, 2021 Cancer is the second leading cause of death worldwide. This work is an effort to find new effective and safe anticancer agents. In accordance with thalidomide features as immunomodulator anticancer drug, we designed and synthesized ten new thalidomide ...
Mohamed El-Zahabi
doaj +1 more source
Cells, 2023 Allergy is a chronic inflammatory disease, and its incidence has increased worldwide in recent years. Thalidomide, which was initially used as an anti-emetic drug but was withdrawn due to its teratogenic effects, is now used to treat blood cancers ...
Hyeun-Wook Chang +2 more
doaj +1 more source