Results 1 to 10 of about 28,419 (118)

Molecular Mechanisms of the Teratogenic Effects of Thalidomide

Pharmaceuticals, 2020
Thalidomide was sold worldwide as a sedative over 60 years ago, but it was quickly withdrawn from the market due to its teratogenic effects. Thalidomide was later found to have therapeutic effects in several diseases, although the molecular mechanisms ...
Hiroshi Handa, Tomoko Asatsuma, Takumi Ito   +2 more
exaly   +3 more sources

Thalidomide affects limb formation and multiple myeloma related genes in human induced pluripotent stem cells and their mesoderm differentiation

Biochemistry and Biophysics Reports, 2021
Although thalidomide is highly teratogenic, it has been prescribed for treating multiple myeloma and Hansen's disease. However, its mechanism of action is not fully understood.
Maho Shimizu, Saoko Tachikawa, Nagatsuki Saitoh, Kohei Nakazono, Liu Yu-Jung, Mika Suga, Kiyoshi Ohnuma   +6 more
doaj   +1 more source

Biological evaluation of both enantiomers of fluoro-thalidomide using human myeloma cell line H929 and others. [PDF]

PLoS ONE, 2017
Over the last few years, thalidomide has become one of the most important anti-tumour drugs for the treatment of relapsed-refractory multiple myeloma. However, besides its undesirable teratogenic side effect, its configurational instability critically ...
Etsuko Tokunaga, Hidehiko Akiyama, Vadim A Soloshonok, Yuki Inoue, Hideaki Hara, Norio Shibata   +5 more
doaj   +1 more source

Antiangiogenic Activity and in Silico Cereblon Binding Analysis of Novel Thalidomide Analogs

Molecules, 2020
Due to its antiangiogenic and anti-immunomodulatory activity, thalidomide continues to be of clinical interest despite its teratogenic actions, and efforts to synthesize safer, clinically active thalidomide analogs are continually underway. In this study,
Megan L. Peach, Shaunna L. Beedie, Cindy H. Chau, Matthew K. Collins, Suzana Markolovic, Weiming Luo, David Tweedie, Christian Steinebach, Nigel H. Greig, Michael Gütschow, Neil Vargesson, Marc C. Nicklaus, William D. Figg   +12 more
doaj   +1 more source

Thalidomide Suppresses Angiogenesis Through the Signal Transducer and Activator of Transcription 3/SP4 Signaling Pathway in the Peritoneal Membrane

Frontiers in Physiology, 2021
Peritoneal angiogenesis is the key pathophysiological factor that limits peritoneal ultrafiltration during peritoneal dialysis (PD) in uremic patients.
Nan Zhu, Ling Wang, Huimin Guo, Jieshuang Jia, Lijie Gu, Xuan Wang, Man Yang, Haochen Guan, Weijie Yuan   +8 more
doaj   +1 more source

DESIGN, MOLECULAR MODELING AND SYNTHESIS OF NEW IMMUNOMODULATORY AGENTS FOR BIOLOGICAL STUDIES [PDF]

Al-Azhar Journal of Pharmaceutical Sciences, 2021
Cancer is the second leading cause of death worldwide. This work is an effort to find new effective and safe anticancer agents. In accordance with thalidomide features as immunomodulator anticancer drug, we designed and synthesized ten new thalidomide ...
Mohamed El-Zahabi
doaj   +1 more source

Thalidomide Attenuates Mast Cell Activation by Upregulating SHP-1 Signaling and Interfering with the Action of CRBN

Cells, 2023
Allergy is a chronic inflammatory disease, and its incidence has increased worldwide in recent years. Thalidomide, which was initially used as an anti-emetic drug but was withdrawn due to its teratogenic effects, is now used to treat blood cancers ...
Hyeun-Wook Chang, Kyeong-Hwa Sim, Youn-Ju Lee   +2 more
doaj   +1 more source

Thalidomide attenuates nitric oxide mediated angiogenesis by blocking migration of endothelial cells

BMC Cell Biology, 2006
Background Thalidomide is an immunomodulatory agent, which arrests angiogenesis. The mechanism of anti-angiogenic activity of thalidomide is not fully understood.
Indhumathy M, Rajaram Megha, Kolluru Gopi, Tamilarasan KP, Saranya R, Chatterjee Suvro   +5 more
doaj   +1 more source

Thalidomide inhibits alternative activation of macrophages in vivo and in vitro: a potential mechanism of anti-asthmatic effect of thalidomide. [PDF]

PLoS ONE, 2015
Thalidomide is known to have anti-inflammatory and immunomodulatory actions. However, the effect and the anti-asthmatic mechanism of thalidomide in the pathogenesis of asthmatic airways are not fully understood.This study is designed to determine the ...
Hyun Seung Lee, Hyouk-Soo Kwon, Da-Eun Park, Yeon Duk Woo, Hye Young Kim, Hang-Rae Kim, Sang-Heon Cho, Kyung-Up Min, Hye-Ryun Kang, Yoon-Seok Chang   +9 more
doaj   +1 more source

Treatment outcome of thalidomide based regimens in newly diagnosed and relapsed/refractory non-transplant multiple myeloma patients: a single center experience from Thailand

Journal of Hematology & Oncology, 2010
Background Thalidomide based regimen is an effective and well tolerated therapy in multiple myeloma (MM) patients, however, there were a small number of studies written about the results of thalidomide therapy in non-transplant MM patients.
Aungchaisuksiri Pantep, Ungkanont Artit, Chuncharunee Suporn, Atichartakarn Vichai, Sorakhunpipitkul Ladda, Niparuck Pimjai, Puavilai Teeraya, Jootar Saengsuree   +7 more
doaj   +1 more source