Results 21 to 30 of about 54,104 (311)
The molecular basis of CRL4 ubiquitin ligase architecture, targeting and regulation [PDF]
, 2013 Members of the CUL4-RBX1-DDB1 (CRL4) E3 ubiquitin ligase family regulate multiple cellular processes including development, transcription, and DNA repair.
Fischer, Eric Sebastian
core +1 more source
Neural Regeneration Research, 2015 Thalidomide is an effective drug for the treatment of ankylosing spondylitis but might induce peripheral neuropathy. This major adverse reaction has attracted much concern.
Hong-xia Xue +5 more
doaj +1 more source
Pediatric Developmental Safety Assessment: Are We Ready for the Next Thalidomide? [PDF]
Clin Pharmacol TherPediatric drug development has achieved remarkable success in the last 20 years with over 1,000 products studied in pediatric patients. This success has been driven in part by an increased understanding of pediatric disease processes. The aspect that has been largely overlooked is the potential adverse effect of new drugs on pediatric developmental ...
Burckart GJ +6 more
europepmc +2 more sources
Molecular mechanisms of thalidomide and its derivatives
Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2020 Thalidomide, originally developed as a sedative drug, causes multiple defects due to severe teratogenicity, but it has been re-purposed for treating multiple myeloma, and derivatives such as lenalidomide and pomalidomide have been developed for treating ...
Takumi Ito, H. Handa
semanticscholar +1 more source
Expression of drug transporters in intestine and blood [PDF]
, 2005 Proteins that are capable to transport molecules across membranes are fundamental for the accurate functioning of the body. Many diseases have their cause in a dysfunction of a particular transport protein.
Zimmermann, Christian
core +1 more source
Thalidomide-induced sinus bradycardia in Crohn’s disease: case report and literature review
Journal of International Medical Research, 2019 Thalidomide is effective in inducing and maintaining clinical remission, as well as mucosal healing, in patients with refractory Crohn’s disease (CD).
Menghui Liu +5 more
doaj +1 more source
CUL5 is required for thalidomide-dependent inhibition of cellular proliferation. [PDF]
PLoS ONE, 2018 Angiogenesis is essential for cancer metastasis, thus the discovery and characterization of molecules that inhibit this process is important. Thalidomide is a teratogenic drug which is known to inhibit angiogenesis and effectively inhibit cancer ...
Bryan Kunkler +11 more
doaj +1 more source
Defining the human C2H2 zinc-finger degrome targeted by thalidomide analogs through CRBN
Science, 2018 Thalidomide-targeted degradation Thalidomide and its analogs improve the survival of patients with multiple myeloma and other blood cancers. Previous work showed that the drugs bind to the E3 ubiquitin ligase Cereblon, which then targets for degradation ...
Quinlan L. Sievers +9 more
semanticscholar +1 more source
Replacing the phthalimide core in thalidomide with benzotriazole
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 The advent of proteolysis-targeting chimaeras (PROTACs) mandates that new ligands for the recruitment of E3 ligases are discovered. The traditional immunomodulatory drugs (IMiDs) such as thalidomide and its analogues (all based on the phthalimide ...
Mikhail Krasavin +8 more
doaj +1 more source
Haematologica, 2010 Background Thalidomide and its analogs are effective agents in the treatment of multiple myeloma. Since gelatinases (matrix metalloproteinases-2 and -9) play a crucial role in tumor progression, we explored the effect of thalidomide on gelatinase ...
Marta Segarra +8 more
doaj +1 more source