Results 21 to 30 of about 36,845 (243)

Thalidomide-induced sinus bradycardia in Crohn’s disease: case report and literature review

Journal of International Medical Research, 2019
Thalidomide is effective in inducing and maintaining clinical remission, as well as mucosal healing, in patients with refractory Crohn’s disease (CD).
Menghui Liu, Xiaoqing Lin, Lichun Wang, Yao He, Minhu Chen, Ren Mao   +5 more
doaj   +1 more source

Expression of drug transporters in intestine and blood [PDF]

, 2005
Proteins that are capable to transport molecules across membranes are fundamental for the accurate functioning of the body. Many diseases have their cause in a dysfunction of a particular transport protein.
Zimmermann, Christian
core   +1 more source

CUL5 is required for thalidomide-dependent inhibition of cellular proliferation. [PDF]

PLoS ONE, 2018
Angiogenesis is essential for cancer metastasis, thus the discovery and characterization of molecules that inhibit this process is important. Thalidomide is a teratogenic drug which is known to inhibit angiogenesis and effectively inhibit cancer ...
Bryan Kunkler, Daniel Salamango, Zachary J DeBruine, Caitlin Ploch, Shirley Dean, David Grossens, Michael P Hledin, Gabriel A Marquez, Julie Madden, Abigayle Schnell, Michael Short, Maria A Burnatowska-Hledin   +11 more
doaj   +1 more source

Phase 1 study to determine the safety, tolerability and immunostimulatory activity of thalidomide analogue CC-5013 in patients with metastatic malignant melanoma and other advanced cancers [PDF]

, 2004
We assessed the safety, tolerability and efficacy of the immunomodulatory drug, CC-5013 (REVIMID(TM)), in the treatment of patients with metastatic malignant melanoma and other advanced cancers.
Muller, G.W., Dredge, K., Clarke, IA, Kristeleit, H., Dredge, K, D I Stirling, A G Dalgleish, Zeldis, J., S Nicholson, Polychronis, A., Kristeleit, H, G W Muller, H Kristeleit, J B Bartlett, Nicholson, S, K Dredge, Stirling, D.I., Michael, A, Dalgleish, A.G., Polychronis, A, Muller, GW, Pandha, H,, Stirling, DI, I A Clarke, Clarke, I.A., Bartlett, JB, Zeldis, J, Nicholson, S., H Pandha, Dalgleish, AG, J Zeldis, Pandha, H, A Polychronis, Michael, A., A Michael, Bartlett, J.B.   +35 more
core   +1 more source

Thalidomide decreases gelatinase production by malignant B lymphoid cell lines through disruption of multiple integrin-mediated signaling pathways

Haematologica, 2010
Background Thalidomide and its analogs are effective agents in the treatment of multiple myeloma. Since gelatinases (matrix metalloproteinases-2 and -9) play a crucial role in tumor progression, we explored the effect of thalidomide on gelatinase ...
Marta Segarra, Ester Lozano, Marc Corbera-Bellalta, Carme Vilardell, Maria-Teresa Cibeira, Jordi Esparza, Nora Izco, Joan Bladé, Maria C. Cid   +8 more
doaj   +1 more source

Replacing the phthalimide core in thalidomide with benzotriazole

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
The advent of proteolysis-targeting chimaeras (PROTACs) mandates that new ligands for the recruitment of E3 ligases are discovered. The traditional immunomodulatory drugs (IMiDs) such as thalidomide and its analogues (all based on the phthalimide ...
Mikhail Krasavin, Andrey Bubyrev, Alexander Kazantsev, Christopher Heim, Samuel Maiwald, Daniil Zhukovsky, Dmitry Dar’in, Marcus D. Hartmann, Alexander Bunev   +8 more
doaj   +1 more source

Rationale use of Thalidomide in erythema nodosum leprosum - A non-systematic critical analysis of published case reports

Revista da Sociedade Brasileira de Medicina Tropical, 2020
INTRODUCTION: Thalidomide is an anti- tumor necrosis factor alpha (TNF-a) drug used mainly in the management of moderate to severe form of Erythema Nodosum Leprosum (ENL).
Pugazhenthan Thangaraju, Sajitha Venkatesan, Meenalotchini Gurunthalingam, Shoban Babu, Tamilselvan T   +4 more
doaj   +1 more source

SAFETY AND EFFICACY OF THALIDOMIDE IN TRANSFUSION-DEPENDENT β-THALASSEMIA: A SYSTEMATIC REVIEW AND META-ANALYSIS

Khyber Medical University Journal, 2022
OBJECTIVE: The current meta-analysis was carried out to identify the efficacy and safety of thalidomide in transfusion-dependent β-thalassemia (TDT) patients. METHODS: Six databases: PubMed, EMBASE, Scopus, Cochrane Library, EBSCOhost, and MEDLINE were
Zahid Ali, Mohammad Ismail, Muhammad Tariq Masood Khan, Inayat Ur Rehman   +3 more
doaj   +1 more source

Thalidomide inhibits fibronectin production in TGF-beta 1-treated normal and keloid fibroblasts via inhibition of the p38/Smad3 pathway

, 2014
Keloids are characterized by the vigorously continuous production of extracellular matrix protein and aberrant cytokine activity in the dermis. There is a growing body of evidence that thalidomide, alpha-N-phthalimidoglutarimide, has anti-fibrotic ...
簡雄飛;陳玉怜;王淑慧;蔡兆勳, Liang, Chan-Jung;Yen, Yu-Hsiu;Hung, Ling-Yi;Wang, Shu-Huei;Pu, Chi-Ming;Chien, Hsiung-Fei;Tsai, Jaw-Shiun;Lee, Chiang-Wen;Yen, Feng-Lin;Chen, Yuh-Lien   +1 more
core   +1 more source

Potential Use of Thalidomide in Glioblastoma Treatment: An Updated Brief Overview

Metabolites, 2023
Glioblastoma is the most common malignant primary brain tumor in adults. Thalidomide is a vascular endothelial growth factor inhibitor that demonstrates antiangiogenic activity, and may provide additive or synergistic anti-tumor effects when co ...
Ahmed Ismail Eatmann, Esraa Hamouda, Heba Hamouda, Hossam Khaled Farouk, Afnan W. M. Jobran, Abdallah A. Omar, Alyaa Khaled Madeeh, Nada Mostafa Al-dardery, Salma Elnoamany, Eman Gamal Abd-Elnasser, Abdullah Muhammed Koraiem, Alhassan Ali Ahmed, Mohamed Abouzid, Marta Karaźniewicz-Łada   +13 more
doaj   +1 more source