Results 11 to 20 of about 36,845 (243)
Thalidomide in dermatology: Revisited
Indian Journal of Dermatology, 2015 The use of thalidomide in relation to dermatology is well- known and enough data is available in the literature about various aspects of thalidomide.
Iffat Hassan +2 more
doaj +4 more sources
Treatment of pyoderma gangrenosum with thalidomide in a myelodysplastic syndrome case
International Medical Case Reports Journal, 2016 Umit Yavuz Malkan, Gursel Gunes, Eylem Eliacik, Ibrahim Celalettin Haznedaroglu Department of Hematology, School of Medicine, Hacettepe University, Ankara, Turkey Abstract: Thalidomide may be used as a treatment option for pyoderma gangrenosum (PG) and ...
Malkan UY +3 more
doaj +2 more sources
Annales de Dermatologie et de Vénéréologie, 2007 Thalidomide was introduced in the 1950s as an antihistamine, and then later as a sedative/hypnotic. Soon thereafter it became infamous for its teratogenic effects and was withdrawn from the market. More recently it was found to be useful in the treatment
Laffitte E, Revuz J
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The Lancet, 2004 Despite its history as a human teratogen, thalidomide is emerging as a treatment for cancer and inflammatory diseases. Although the evolution of its clinical application could not have been predicted from the tragedy associated with its misuse in the past, its history serves as a lesson in drug development that underscores the need to understand the ...
Franks, Michael E. +2 more
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Immunomodulation by thalidomide and thalidomide analogues [PDF]
Annals of the Rheumatic Diseases, 1999 Tumour necrosis factor α (TNFα), a key cytokine involved in the host immune response, also contributes to the pathogenesis of both infectious and autoimmune diseases. To ameliorate the pathology resulting from TNFα in these clinical settings, strategies for the inhibition of this cytokine have been developed.
L G, Corral, G, Kaplan
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The molecular basis of CRL4 ubiquitin ligase architecture, targeting and regulation [PDF]
, 2013 Members of the CUL4-RBX1-DDB1 (CRL4) E3 ubiquitin ligase family regulate multiple cellular processes including development, transcription, and DNA repair.
Fischer, Eric Sebastian
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Antipruritic action of thalidomide
, 2000 The effect of thalidomide on itch was studied in 11 patients with chronic pruritus from psoriasis, eczema, nodular prurigo, senile pruritus and primary biliary cirrhosis.
Shuster S, Martina Daly B
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Inhibition of metastatic potential in colorectal carcinoma in vivo and in vitro using immunomodulatory drugs (IMiDs) [PDF]
, 2009 Thalidomide and lenalidomide are FDA approved for the treatment of multiple myeloma and, along with pomalidomide, are being investigated in various other cancers. Although these agents display immunomodulatory, anti-angiogenic and anti-apoptotic effects,
Galustian, C +15 more
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Neural Regeneration Research, 2015 Thalidomide is an effective drug for the treatment of ankylosing spondylitis but might induce peripheral neuropathy. This major adverse reaction has attracted much concern.
Hong-xia Xue +5 more
doaj +1 more source
Thalidomide and discoid lupus erythematosus: case series and review of literature
, 2022 Background: The anti-inflammatory drug, thalidomide, is often administered off-label especially in dermatology patients with diseases refractory to different medications.
Trifirò, Caterina +13 more
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