Results 11 to 20 of about 28,127 (210)

Thalidomide inhibits alternative activation of macrophages in vivo and in vitro: a potential mechanism of anti-asthmatic effect of thalidomide. [PDF]

PLoS ONE, 2015
Thalidomide is known to have anti-inflammatory and immunomodulatory actions. However, the effect and the anti-asthmatic mechanism of thalidomide in the pathogenesis of asthmatic airways are not fully understood.This study is designed to determine the ...
Hyun Seung Lee, Hyouk-Soo Kwon, Da-Eun Park, Yeon Duk Woo, Hye Young Kim, Hang-Rae Kim, Sang-Heon Cho, Kyung-Up Min, Hye-Ryun Kang, Yoon-Seok Chang   +9 more
doaj   +1 more source

Treatment outcome of thalidomide based regimens in newly diagnosed and relapsed/refractory non-transplant multiple myeloma patients: a single center experience from Thailand

Journal of Hematology & Oncology, 2010
Background Thalidomide based regimen is an effective and well tolerated therapy in multiple myeloma (MM) patients, however, there were a small number of studies written about the results of thalidomide therapy in non-transplant MM patients.
Aungchaisuksiri Pantep, Ungkanont Artit, Chuncharunee Suporn, Atichartakarn Vichai, Sorakhunpipitkul Ladda, Niparuck Pimjai, Puavilai Teeraya, Jootar Saengsuree   +7 more
doaj   +1 more source

High-dose thalidomide increases the risk of peripheral neuropathy in the treatment of ankylosing spondylitis

Neural Regeneration Research, 2015
Thalidomide is an effective drug for the treatment of ankylosing spondylitis but might induce peripheral neuropathy. This major adverse reaction has attracted much concern.
Hong-xia Xue, Wen-yi Fu, Hua-dong Cui, Li-li Yang, Ning Zhang, Li-juan Zhao   +5 more
doaj   +1 more source

Molecular Mechanisms of the Teratogenic Effects of Thalidomide

Pharmaceuticals, 2020
Thalidomide was sold worldwide as a sedative over 60 years ago, but it was quickly withdrawn from the market due to its teratogenic effects. Thalidomide was later found to have therapeutic effects in several diseases, although the molecular mechanisms ...
Tomoko Asatsuma-Okumura, Takumi Ito, Hiroshi Handa   +2 more
doaj   +1 more source

Pediatric Developmental Safety Assessment: Are We Ready for the Next Thalidomide? [PDF]

Clin Pharmacol Ther
Pediatric drug development has achieved remarkable success in the last 20 years with over 1,000 products studied in pediatric patients. This success has been driven in part by an increased understanding of pediatric disease processes. The aspect that has been largely overlooked is the potential adverse effect of new drugs on pediatric developmental ...
Burckart GJ, Abdel-Rahman SM, Abulwerdi G, Samuels S, Racz R, Mohamoud MA, Tatonetti NP.   +6 more
europepmc   +2 more sources

Thalidomide-induced sinus bradycardia in Crohn’s disease: case report and literature review

Journal of International Medical Research, 2019
Thalidomide is effective in inducing and maintaining clinical remission, as well as mucosal healing, in patients with refractory Crohn’s disease (CD).
Menghui Liu, Xiaoqing Lin, Lichun Wang, Yao He, Minhu Chen, Ren Mao   +5 more
doaj   +1 more source

CUL5 is required for thalidomide-dependent inhibition of cellular proliferation. [PDF]

PLoS ONE, 2018
Angiogenesis is essential for cancer metastasis, thus the discovery and characterization of molecules that inhibit this process is important. Thalidomide is a teratogenic drug which is known to inhibit angiogenesis and effectively inhibit cancer ...
Bryan Kunkler, Daniel Salamango, Zachary J DeBruine, Caitlin Ploch, Shirley Dean, David Grossens, Michael P Hledin, Gabriel A Marquez, Julie Madden, Abigayle Schnell, Michael Short, Maria A Burnatowska-Hledin   +11 more
doaj   +1 more source

Thalidomide decreases gelatinase production by malignant B lymphoid cell lines through disruption of multiple integrin-mediated signaling pathways

Haematologica, 2010
Background Thalidomide and its analogs are effective agents in the treatment of multiple myeloma. Since gelatinases (matrix metalloproteinases-2 and -9) play a crucial role in tumor progression, we explored the effect of thalidomide on gelatinase ...
Marta Segarra, Ester Lozano, Marc Corbera-Bellalta, Carme Vilardell, Maria-Teresa Cibeira, Jordi Esparza, Nora Izco, Joan Bladé, Maria C. Cid   +8 more
doaj   +1 more source

Replacing the phthalimide core in thalidomide with benzotriazole

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
The advent of proteolysis-targeting chimaeras (PROTACs) mandates that new ligands for the recruitment of E3 ligases are discovered. The traditional immunomodulatory drugs (IMiDs) such as thalidomide and its analogues (all based on the phthalimide ...
Mikhail Krasavin, Andrey Bubyrev, Alexander Kazantsev, Christopher Heim, Samuel Maiwald, Daniil Zhukovsky, Dmitry Dar’in, Marcus D. Hartmann, Alexander Bunev   +8 more
doaj   +1 more source

Generalizable Strategies for the Synthesis of Cereblon‐Recruiting PROTAC Prodrugs

Angewandte Chemie, EarlyView.
Cereblon‐recruiting PROTACs remain challenging to derivatize for prodrug‐based delivery. In this study, three complementary conjugation strategies enabled the efficient synthesis of cleavable PROTAC prodrugs with tunable release kinetics that can be incorporated into a library of PEGylated constructs and bottlebrush prodrugs.
Aiden X. Wang, Bin Liu, Elise M. Ackerman, Yichen Xiang, Hung V.‐T. Nguyen, Yivan Jiang, Angela N. Koehler, Jeremiah A. Johnson   +7 more
wiley   +2 more sources