Results 31 to 40 of about 54,104 (311)
eLife, 2018 In historical attempts to treat morning sickness, use of the drug thalidomide led to the birth of thousands of children with severe birth defects. Despite their teratogenicity, thalidomide and related IMiD drugs are now a mainstay of cancer treatment ...
K. Donovan +7 more
semanticscholar +1 more source
Palladacarboxamide Capping Reagents for Carbon Isotope Labeling and Pharmaceutical Diversification
Angewandte Chemie, EarlyView.Herein, we present a method for carbon isotope labeling of arylamides via the coupling of air‐stable palladium carboxamide complexes and boronic ester/acids. A wide variety of functionalized boronic esters and acids have been coupled with simple palladium carboxamides complexes.
Daniel V. Hoffmann +8 more
wiley +2 more sources
A Systematic Review of Literature: TNF-α Blockers and JAK Inhibitors for the Treatment of Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis, and Severe Forms of Erythema Multiforme. [PDF]
Health Sci RepABSTRACT Background and Aims Stevens‐Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and erythema multiforme major (EM major) are severe dermatologic conditions characterized by varying degrees of skin detachment and involvement of mucosal membranes, often triggered by drug reactions or infections.
Salehi S +6 more
europepmc +2 more sources
EBioMedicine, 2017 Trial Design: Open-label, randomised, controlled, pilot proof-of-concept clinical trial. Methods: Participants: Antiretroviral naïve adult males with CD4 count ≥350 cells/mm3. Interventions: Patients were randomised to receive thalidomide 200 mg QD for 3
Tânia R.C. Vergara +11 more
doaj +1 more source
Khyber Medical University Journal, 2022 OBJECTIVE: The current meta-analysis was carried out to identify the efficacy and safety of thalidomide in transfusion-dependent β-thalassemia (TDT) patients. METHODS: Six databases: PubMed, EMBASE, Scopus, Cochrane Library, EBSCOhost, and MEDLINE were
Zahid Ali +3 more
doaj +1 more source
Thalidomide and neurotrophism [PDF]
Skeletal Radiology, 2018 Following the thalidomide disaster (1958-62), Henkel and Willert analysed the pattern of dysmelia in the long bones (J Bone Joint Surg Br. 51:399-414, 1969) and the extremities, Willert and Henkel (Z Orthop Ihre Grenzgeb. 107:663-75, 1970). Willert's material from deformed extremities is re-examined here asking "How does thalidomide reduce the skeleton?
Judith R. Soper +4 more
openaire +3 more sources
Veterinary Sciences, 2020 Hemangiosarcomas (HSA) are common neoplasms of dogs that often metastasize and are typically fatal. Recently it was demonstrated that thalidomide extends the survival time of dogs with HSA, potentially due to thalidomide-induced inhibition of vascular ...
Jonathan P. Bray, John S. Munday
doaj +1 more source
Potential Use of Thalidomide in Glioblastoma Treatment: An Updated Brief Overview
Metabolites, 2023 Glioblastoma is the most common malignant primary brain tumor in adults. Thalidomide is a vascular endothelial growth factor inhibitor that demonstrates antiangiogenic activity, and may provide additive or synergistic anti-tumor effects when co ...
Ahmed Ismail Eatmann +13 more
doaj +1 more source
Recent advances in the molecular mechanism of thalidomide teratogenicity.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020 Thalidomide was first marketed in 1957 but soon withdrawn because of its notorious teratogenicity. Studies on the mechanism of action of thalidomide revealed the pleiotropic properties of this class of drugs, including their anti-inflammatory ...
Shaobing Gao +3 more
semanticscholar +1 more source
, 2014 Keloids are characterized by the vigorously continuous production of extracellular matrix protein and aberrant cytokine activity in the dermis. There is a growing body of evidence that thalidomide, alpha-N-phthalimidoglutarimide, has anti-fibrotic ...
簡雄飛;陳玉怜;王淑慧;蔡兆勳 +1 more
core +1 more source