Results 31 to 40 of about 28,127 (210)
POEMS Syndrome: 2026 Update on Diagnosis, Risk‐Stratification, and Management
American Journal of Hematology, EarlyView.ABSTRACT Disease Overview POEMS syndrome is a life‐threatening syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease.
Angela Dispenzieri
wiley +1 more source
THALIDOMIDE AMELIORATES ERYTHROPOIESIS AND IRON HOMEOSTASIS IN TRANSFUSION-DEPENDENT β-THALASSEMIA
Mediterranean Journal of Hematology and Infectious DiseasesThalidomide is a therapeutic option for patients with β-thalassemia by increasing fetal hemoglobin and thereby reducing the requirement for blood transfusions.
Kun Yang, Jian Xiao
doaj +1 more source
Systemic Bevacizumab for Severe Bleeding From Acquired Gastrointestinal Vascular Malformations
American Journal of Hematology, EarlyView.Targeted antiangiogenic therapy with systemic bevacizumab for bleeding from acquired GI VMs was found to be safe and effective for chronic and severe bleeding from acquired vascular malformations due to idiopathic angiodysplasia, chronic liver disease, and deficiencies of von Willebrand factor, in a patient population comprised mostly of heavily ...
Nardeen E. Ayad +5 more
wiley +1 more source
Pharmaceuticals, 2023 The pharmacological and toxicological effects of active metabolites of enzymes including cytochrome P450 (CYP) are important. While it has been believed for a long time that thalidomide causes characteristic limb malformation only in rabbits and primates
Wenjing Dong +8 more
doaj +1 more source
Thalidomide surveillance and pharmacovigilance in Brazil – an overview
Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2020 Introduction: The thalidomide is probably the best-known teratogenic drug and still results in cases of severe physical deformities in children born in Brazil.
Lisiane Freitas Leal +1 more
doaj
The effect of thalidomide on visceral fat pad mass and triglyceride concentration of the skeletal muscles in rats [PDF]
Yeungnam University Journal of Medicine, 2018 Background Body fats, especially both of abdominal fat pad mass and skeletal muscle fat content, are inversely related to insulin action. Therefore, methods for decreasing visceral fat mass and muscle triglyceride content may be helpful for the ...
Ki-Hoon Kim +2 more
doaj +1 more source
Reversible Pulmonary Hypertension Related to Thalidomide Treatment for Multiple Myeloma
Case Reports in Oncology, 2011 Multiple myeloma (MM) is thrombogenic as a consequence of multiple hemostatic effects. Thalidomide is an effective treatment; however, it has been associated with an increased risk of thromboembolic events including pulmonary hypertension (PH). PH in the
Antonio Villa +4 more
doaj +1 more source
Signal Transduction and Targeted Therapy, 2021 Thalidomide induces γ-globin expression in erythroid progenitor cells, but its efficacy on patients with transfusion-dependent β-thalassemia (TDT) remains unclear.
Jiang-Ming Chen +30 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Small and mid‐sized pharmaceutical innovators often have limited in‐house health economics and market access expertise, and may struggle to align development strategies of investigational medicinal products with health system needs and payer expectations.
Zoltán Kaló +5 more
wiley +1 more source
Scientific ReportsStudies of (S)-thalidomide were conducted on zebrafish embryos subjected to electroporation processes using a square wave pulse generator. The results showed that the electroporation increases the absorption of (S)-thalidomide through the chorion into ...
Anna Małkowska +7 more
doaj +1 more source