Results 41 to 50 of about 54,104 (311)
Revista da Sociedade Brasileira de Medicina Tropical, 2020 INTRODUCTION: Thalidomide is an anti- tumor necrosis factor alpha (TNF-a) drug used mainly in the management of moderate to severe form of Erythema Nodosum Leprosum (ENL).
Pugazhenthan Thangaraju +4 more
doaj +1 more source
Thalidomide for Patients with β-Thalassemia: A Multicenter Experience
Mediterranean Journal of Hematology and Infectious Diseases, 2020 Objective This study focused on the efficacy and safety of thalidomide for patients with β-thalassemia in a multicenter trial. Methods Patients with non-transfusion-dependent thalassemia (NTDT) or transfusion-dependent thalassemia (TDT), who were unable ...
Kun Yang +8 more
semanticscholar +1 more source
, 2009 Thalidomide and lenalidomide are FDA approved for the treatment of multiple myeloma and, along with pomalidomide, are being investigated in various other cancers. Although these agents display immunomodulatory, anti-angiogenic and anti-apoptotic effects,
Galustian, C +15 more
core +1 more source
Neuroinflammation as a Factor of Neurodegenerative Disease: Thalidomide Analogs as Treatments
Front. Cell Dev. Biol., 2019 Neuroinflammation is initiated when glial cells, mainly microglia, are activated by threats to the neural environment, such as pathogen infiltration or neuronal injury.
Y. Jung +3 more
semanticscholar +1 more source
Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology), 2016 Background: Treatment thalidomide in erythema nodosum leprosum (ENL), can inhibits the transcription repression mediated by tumor necroting factor (TNF). Thalidomide can be used as sparing agents drug to reduce the dependency of steroid.
Dian Pertiwi Habibie +1 more
doaj +1 more source
Pharmaceuticals, 2023 The pharmacological and toxicological effects of active metabolites of enzymes including cytochrome P450 (CYP) are important. While it has been believed for a long time that thalidomide causes characteristic limb malformation only in rabbits and primates
Wenjing Dong +8 more
doaj +1 more source
Frontiers in Immunology, 2020 The coronavirus disease 2019 (COVID-19) pandemic is a worldwide threatening health issue. The progression of this viral infection occurs in the airways of the lungs with an exaggerated inflammatory response referred to as the “cytokine storm” that can ...
A. Khalil, Amina Kamar, G. Nemer
semanticscholar +1 more source
Thalidomide induced impotence in male hematology patients: a common but ignored complication?
Haematologica, 2007 Thalidomide has become an important agent in the treatment of myeloma. However, thalidomide induced erectile dysfunction is a serious complication which has received very little attention. In our hematology department, 6 out of 11 male patients developed
Philip T. Murphy, John Rory O’Donnell
doaj +1 more source
Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation
Advanced Science, EarlyView.VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang +15 more
wiley +1 more source
Synergistic anti-allodynic effect between intraperitoneal thalidomide and morphine on rat spinal nerve ligation-induced neuropathic pain [PDF]
Korean Journal of Anesthesiology, 2013 BackgroundThalidomide has been recognized as having an anti-allodynic effect against neuropathic pain induced by spinal nerve ligation. Its clinical beneficial effects are mainly derived from its immune-modulating property, which is known to influence ...
Hyung Gon Lee +4 more
doaj +1 more source