Results 41 to 50 of about 36,845 (243)
Advanced Science, EarlyView.We present a versatile DNA‐encoded library (DEL) platform designed for rapid library synthesis and subsequent screening for chemical inducers of proximity (CIPs) across various presenter proteins of choice. Applying this approach, we discovered a novel molecular glue‐like compound mediating CRBN‐BRD9 ternary complex formation with remarkable ...
Bingqi Tong +11 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Small and mid‐sized pharmaceutical innovators often have limited in‐house health economics and market access expertise, and may struggle to align development strategies of investigational medicinal products with health system needs and payer expectations.
Zoltán Kaló +5 more
wiley +1 more source
Nutritional, pharmacological and hormonal manipulation of muscle metabolism [PDF]
, 2010 PhDSarcopenia and cachexia occur when there is a deficit between the rates of muscle protein synthesis and breakdown, such that a negative balance exists.
Wilkes, Emilie Anne
core +3 more sources
Thalidomide surveillance and pharmacovigilance in Brazil – an overview
Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2020 Introduction: The thalidomide is probably the best-known teratogenic drug and still results in cases of severe physical deformities in children born in Brazil.
Lisiane Freitas Leal +1 more
doaj
BMJ, 1994 EDITOR, - Use of thalidomide only on a named patient basis does not necessarily mean that patients are protected from its side effects, as implied by Baroness Cumberlege, the junior health minister.1 According to Sir William Asscher, the former chairman of the Committee on the Safety of Medicines, “the companies who supply a drug for named patient use ...
openaire +2 more sources
Thalidomide-associated thrombocytopenia
, 2005 OBJECTIVE: To report thrombocytopenia in a patient prescribed thalidomide for multiple myeloma (MM). CASE SUMMARY: A 70-year-old woman was diagnosed in 2003 with MM.
Kingma, Bert J. +3 more
core +2 more sources
Thalidomide attenuates the hyporesponsiveness of isolated atria to chronotropic stimulation in BDL rats: The involvement of TNF-α, IL-6 inhibition, and SOCS1 activation [PDF]
Iranian Journal of Basic Medical Sciences, 2019 Objective(s): Cirrhotic cardiomyopathy is a complication of uncured cirrhosis which is associated with hyporesponsiveness of the heart to sympathetic stimulation. The enhancement of portal pressure, nitric oxide (NO) level, pro-inflammatory mediators and
Ali Hosseini-chegeni +5 more
doaj +1 more source
Thalidomide and neurotrophism [PDF]
Skeletal Radiology, 2018 Following the thalidomide disaster (1958-62), Henkel and Willert analysed the pattern of dysmelia in the long bones (J Bone Joint Surg Br. 51:399-414, 1969) and the extremities, Willert and Henkel (Z Orthop Ihre Grenzgeb. 107:663-75, 1970). Willert's material from deformed extremities is re-examined here asking "How does thalidomide reduce the skeleton?
Judith R. Soper +4 more
openaire +3 more sources
British Journal of Clinical Pharmacology, EarlyView.Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden +3 more
wiley +1 more source
Scientific ReportsStudies of (S)-thalidomide were conducted on zebrafish embryos subjected to electroporation processes using a square wave pulse generator. The results showed that the electroporation increases the absorption of (S)-thalidomide through the chorion into ...
Anna Małkowska +7 more
doaj +1 more source